Abstract: The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl peperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferable asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

Abstract: A method and apparatus (2) for providing at least a bead (4) on a side wall portion (10) of a metal container (8). The apparatus includes a mandrel (16) over which side wall portions (10) of the container are disposed. The mandrel (16) has reaction members (20) with reaction surfaces for supporting the side wall portion internally and a plurality of forming members (18) surrounding the mandrel having forming surfaces being substantially parallel with the reaction surfaces but separated therefrom to define a gap between the surfaces which receives the side wall portion (10). The reaction members (20) and forming members (18) are capable of displacement towards and away from one another such that the gap between the reaction surfaces and forming surfaces can effectively expand and contract. The reaction surfaces and forming surfaces are provided with complementary formations thereon to deform the side wall portion therebetween and form a bead (4) therein.

Abstract: A child-resistant closure container system allowing easy opening by debilitated adults. The closure has moveable panels on the side wall which, when depressed, allow the unscrewing of the closure from the neck of the jar or vial. The moveable panels include gabs engaging stationary locking lugs on the neck finish annulus, which prevent removal of the closure without depressing the tabs. The annulus and stationary locking lugs can be an integral part of the jar or vial.

Abstract: There are disclosed compositions and methods for treating the surface of the eye, or contact tenses to be placed on the eye, with an aqueous composition comprising a quaternary nitrogen-containing ethoxylated glycoside and a therapeutic agent. The subject invention is particularly suited for use with silicone-containing contact lenses. Examples of specific compositions include aqueous solutions of lauryl methyl gluceth-10 hydroxypropyl-dimonium chloride in combination with anionic polysaccharides such as hyaluronic acid.

Abstract: Low-density uncreped through-air-dried webs containing bleached chemithermomechanical pulp fibers and a wet-strength resin are calendered to significantly increase density and reduce caliper. When wetted, these webs substantially return to their original caliper and density and substantially regain their original fluid-handling characteristics. Consequently these webs are very thin when dry and thick when wet. They can be used for a wide variety of applications, including paper towels, wipers and fluid-handling components for infant care and personal care products.

Abstract: The invention encompasses a locus control subregion that possesses chromatin opening domain activity, the activity conferring reproducible activation of tissue-specific expression on a linked transgene to a non-physiological level when the transgene is integrated in single copy in the genome of a host cell.

Abstract: A hot dip coating pot (2) having a strip inlet passage (3) and electro-magnetic plugging means to prevent leakage of bath liquid form the pot through that passage, wherein: the plugging means comprises two magnetic field generator (7) disposed one on each side of the passage; each generator projects an oscillating magnetic field into the passage from at least two poles of opposite polarity that are adjacent the passage and spaced apart in the through direction of the passage; the said at least two poles of each generator are respectively in substantial alignment with the corresponding poles of the other in the transverse direction of the passage; the magnetic field projected by the generators have flux patterns which are substantially mirror images with reference to a plane of reflection coinciding with a centre plane of the passage; and both generators operate at a frequency of more than seven kiloHertz. When no strip is present the fields combine and extend transversely of the passage.

Abstract: Disclosed is a process for fractionating cellulosic fibers that is effective to result in cellulosic fibers that exhibit desired properties such as fiber length and fiber coarseness values. The fractionating process is quite efficient and has been found to produce cellulosic fibers that are more homogeneous in their properties as compared to the starting mixture of cellulosic fibers. Also disclosed is a handsheet prepared from the fractionated cellulosic fibers for use in disposable absorbent products.

Abstract: A process for fractionating cellulosic fibers that is effective to result in cellulosic fibers that exhibit desired properties such as fiber length and fiber coarseness values. The fractionating process is quite efficient and has been found to produce cellulosic fibers that are more homogeneous in their properties as compared to the starting mixture of cellulosic fibers. Also disclosed is a handsheet prepared from the fractionated cellulosic fibers for use in disposable absorbent products.

Abstract: There are disclosed compositions and methods for cleaning contact lenses using water soluble enzyme-polymer conjugates. A preferred method includes providing the subject enzyme-polymer conjugates in a tablet form, dissolving the tablet in an aqueous solution and subsequently soaking a contact lens in the resulting solution. Other methods include providing the enzyme-polymer conjugate in a liquid form and contacting a contact lens therewith.

Abstract: Method and apparatus for retarding a flow of molten metal to a metal caster. The flow of molten metal is confined within a duct 11 having an elongate cross-section transverse to the flow directions to shape the flow in a sheet formation. The sheet formation flow is subjected to a magnetic field extending through the flow transversely of the sheet formation and varying sinusoidally along the flow direction whereby to induce circulating electric currents in the molten metal which interact with the magnetic field to produce forces on the molten metal which retard the flow. The magnetic field may be induced by two sets 13 of permanent magnets 14 spaced one set to either side of the duct 11, the magnets 14 of each set being spaced along the flow direction and being of successively opposite magnetic polarity.

Abstract: A child-resistant closure container system allowing easy opening by debilitated adults. The closure has moveable panels on the side wall which, when depressed, allow the unscrewing of the closure from the neck of the jar or vial. The moveable panels include tabs engaging stationary locking lugs on the neck finish annulus, which prevent removal of the closure without depressing the tabs. The annulus and stationary locking lugs can be an integral part of the jar or vial.

Abstract: Low-density uncreped through-air-dried webs containing bleached chemithermomechanical pulp fibers and a wet-strength resin are calendered to significantly increase density and reduce caliper. When wetted, these webs substantially return to their original caliper and density and substantially regain their original fluid-handling characteristics. Consequently these webs are very thin when dry and thick when wet. They can be used for a wide variety of applications, including paper towels, wipers and fluid-handling components for infant care and personal care products.

Abstract: A ratchet wrench including the preferred embodiment of the invention comprises a ratchet head having a conventional ratchet system for rotating a shank about an axis, a connecting pin, and a handle. The generally cylindrical connecting pin is aligned along an axis parallel to the shank axis and is attached to the ratchet head. The connecting pin extends through an orifice in the handle, thereby connecting the handle to the ratchet head. The handle is slidable between a locked position and a unlocked position on the connecting pin. When the handle is in the locked position, splines on the forward end of the handle engage complimentary splines on the ratchet head, thereby allowing the ratchet wrench can be used to rotate a nut or bolt in a conventional manner. When the handle is in the unlocked position, the ratchet wrench can be used to rapidly rotate a nut or bolt by moving the handle in a reciprocating manner.

Abstract: A child-resistant closure container system allowing easy opening by debilitated adults. The closure has moveable panels on the side wall which, when depressed, allow the unscrewing of the closure from the neck of the jar or vial. The moveable panels include tabs engaging stationary locking lugs on the neck finish annulus, which prevent removal of the closure without depressing the tabs. The annulus and stationary locking lugs can be an integral part of the jar or vial.

Abstract: The invention is an apparatus for initiating a wellbore perforator comprising a first firing head for generating a first explosive signal when a first actuation signal is applied to the first firing head, a second firing head for generating a second explosive signal when a second actuation signal is applied to the second firing head, a first means for transferring the first explosive signal to shaped charges in the perforator including a first bulkhead interposed between the shaped charges and the first means for preventing transfer of low order initiation of the first means to the shaped charges, and a second means for transferring the second explosive signal to the shaped charges including a second bulkhead interposed between the shaped charges and the second means for preventing transfer of low order initiation of the second means to the shaped charges.

Abstract: The invention is a firing circuit for an exploding bridgewire explosive detonator which is activated only by application of an alternating current of a preselected frequency. The firing circuit comprises a bandpass filter, a voltage multiplier, and a discharge circuit.The invention can be configured to selectively detonate a plurality of exploding bridgewire detonators by assembling a plurality of firing circuits for each exploding bridgewire, each firing circuit having a bandpass filter with a different preselected frequency.

Abstract: An apparatus for perforating an earth formation from a borehole having a housing, a detonator assembly, explosive material for producing the implosion forces and a metal liner of implosive geometry. The detonator assembly includes a predetermined pattern of precision electronic detonators based on exploding foil initiator, exploding bridge wire, spark gap or laser technology to simultaneously produce multiple initiation points of the explosive material for enhancing the implosion forces.

Abstract: A system (10) for chilling warm animal carcasses (30) more quickly and without substantial tissue shrinkage from dehydration includes an enclosure (12) defining a first subchamber (24) and a second subchamber (26). The carcasses (30) are conveyed into the first subchamber (24) for liquid immersion into a tank (52) of cryogenic fluid to crust-freeze the exterior carcass portions. Following immersion, the semi-chilled carcasses (30) are held in the second chamber (26) while cryogenically refrigerated, sub-freezing gas is circulated around the carcasses to complete the chilling process.