Patents by Inventor James Ernst
James Ernst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7820806Abstract: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in bacterial cell hosts.Type: GrantFiled: June 22, 2009Date of Patent: October 26, 2010Assignee: Genentech, Inc.Inventors: James A. Ernst, Daniel Yansura, Hok Seon Kim
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Publication number: 20100266593Abstract: The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.Type: ApplicationFiled: June 29, 2010Publication date: October 21, 2010Applicant: Genentech, Inc.Inventors: James A. Ernst, Paul Polakis, Bonnee Rubinfeld, Venita I. DeAlmeida
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Patent number: 7691989Abstract: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in bacterial cell hosts.Type: GrantFiled: December 22, 2005Date of Patent: April 6, 2010Assignee: Genentech, Inc.Inventors: James A. Ernst, Daniel Yansura, Hok Seon Kim
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Publication number: 20100081170Abstract: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in bacterial cell hosts.Type: ApplicationFiled: August 14, 2009Publication date: April 1, 2010Applicant: Genentech, Inc.Inventors: James A. ERNST, Daniel Yansura, Hok Seon Kim
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Publication number: 20100057957Abstract: A reconfigurable FADEC includes a reconfigurable CPU configured for performing digital computing functions. A reconfigurable MSPD communicates with the CPU and is configured for performing analog I/O functions. A data bus is coupled to the CPU and the MSPD. The data bus is configured for connecting the CPU and the MSPD to an external connector.Type: ApplicationFiled: August 29, 2008Publication date: March 4, 2010Applicant: Rolls-Royce CorporationInventors: Lawrence Mitchell Smilg, James Ernst, Robert Zeller
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Publication number: 20090258410Abstract: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in bacterial cell hosts.Type: ApplicationFiled: June 22, 2009Publication date: October 15, 2009Applicant: Genentech, Inc.Inventors: James A. ERNST, Daniel Yansura, Hok Seon Kim
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Publication number: 20080299136Abstract: The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.Type: ApplicationFiled: September 7, 2007Publication date: December 4, 2008Applicant: Genentech, Inc.Inventors: James A. Ernst, Paul Polakis, Bonnee Rubinfeld, Venita I. DeAlmeida
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Publication number: 20080040857Abstract: A bariatric transport is provided. The transport includes a bed area for use by a bariatric patient. The transport further includes a drive assembly that is operable to selectively drive the transport in forward and rearward directions and permit turning of the transport with little or no lateral movement of the transport. Leading and trailing stabilizing wheel assemblies are provided that are selectively moveable into and out of engagement with a supporting floor. Drive devices are also provided to provide selective elevating and lowering of various components of bariatric patient supports.Type: ApplicationFiled: October 24, 2007Publication date: February 21, 2008Inventors: DuWayne Karmer, James Ernst, Timothy Dunfee, Brian Mellies
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Publication number: 20060172385Abstract: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in bacterial cell hosts.Type: ApplicationFiled: December 22, 2005Publication date: August 3, 2006Applicant: GENENTECH, INC.Inventors: James Ernst, Daniel Yansura, Hok Seon Kim
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Publication number: 20060059623Abstract: A bariatric transport is provided. The transport includes a bed area for use by a bariatric patient. The transport further includes a drive assembly that is operable to selectively drive the transport in forward and rearward directions and permit turning of the transport with little or no lateral movement of the transport. Leading and trailing stabilizing wheel assemblies are provided that are selectively moveable into and out of engagement with a supporting floor. Drive devices are also provided to provide selective elevating and lowering of various components of bariatric patient supports.Type: ApplicationFiled: June 27, 2005Publication date: March 23, 2006Inventors: Duwayne Karmer, James Ernst, Timothy Dunfee, Brian Mellies
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Publication number: 20050031055Abstract: A bit slicer system is provided for synchronizing a data stream. The bit slicer system includes a processor that may include a shift register and a plurality of particle processors coupled to the shift register. Each particle processor may be configured to generate a voted majority for a plurality of binary samples. The processor may also include a bit function generator coupled to the plurality of particle processors that is configured to generate a score from the plurality of voted majorities. The processor may read binary samples from a data stream, shift the binary samples through the shift register, load subsets of the binary samples into the particle processors, load voted majorities generated by the particle processors into the bit function generator, and adjust the shift register based on the score generated by the bit function generator.Type: ApplicationFiled: August 3, 2004Publication date: February 10, 2005Applicant: INDesign, LLC, (an Indiana limited liability company)Inventor: James Ernst
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Patent number: 6290011Abstract: A powered wheelchair for disabled persons is provided that has a frame that has a first end and a second end. A seat support is coupled to the frame between the first and second ends. A pair of swivel wheels is coupled to the frame proximate the first end and a pair of motor driven wheels is connected to the frame proximate the second end. A motor is coupled to each of the driven wheels. The motors are adapted to allow a change in the rotational direction of the driven wheel to which it is coupled, wherein the rotational direction of the motors may be changed when the wheelchair is converted from a rear wheel drive wheelchair to a front wheel drive wheelchair. At least one battery is coupled to the motors, the battery providing power to the motors. An electronic controller is coupled to the motors and the battery. The controller has a user interface that is used to direct the speed and direction of the wheelchair. A seat assembly is reversibly coupled to the seat support and extends upwardly above the frame.Type: GrantFiled: November 1, 1999Date of Patent: September 18, 2001Assignee: Burke Mobility Products, Inc.Inventors: John T. Langaker, DuWayne E. Kramer, Jr., Jerry L. Traylor, James Ernst
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Patent number: 6220382Abstract: A powered wheelchair for disabled persons is provided that has a center frame that has a first end and a second end. The wheelchair further has a seat support coupled to the center frame between the first and second ends. A pair of rear stabilizing wheels is connected to the center frame near the first end. The wheelchair further includes a drive assembly that is removably coupled to the center frame near the second end. The drive assembly has a pair of drive wheels that each have a motor operably connected thereto. A coupling mechanism is associated with the frame and the drive assembly that removably couples the frame to the drive assembly. The coupling mechanism is applicable and releasable by hand without the use of any tools. A power source is removably held on the center frame generally between the first and second ends, and is electrically connected to each of the motors. A seat assembly is removably coupled to the seat support that extends upwardly above the center frame.Type: GrantFiled: November 17, 1998Date of Patent: April 24, 2001Assignee: Burke Mobility Products, Inc.Inventors: Duwayne E. Kramer, Jr., Jerry L. Traylor, James Ernst
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Patent number: 5816614Abstract: A tiller assembly for steering a personal mobility vehicle. A knuckle joint for the tiller includes a base secured on the front wheel steering spindle and a knuckle element connected for limited pivotal movement on the base. A bolt connects the knuckle element to the base and also connects the tiller to the knuckle joint. A spring loaded pin on the tiller enters spaced apart openings in the knuckle element to lock the tiller to the knuckle element in any one of various positions, including an operating position and a collapsed position. Adjustment screws on the base are contacted by stop surfaces on the knuckle element to limit in both directions the pivoting of the knuckle element. This allows the tiller to float to a limited extent and also to act rigidly when the vehicle user needs to pull himself up by using the tiller. Spacer sleeves on the pivot bolt allow adjustment of the friction between the knuckle element and base without affecting the tiller.Type: GrantFiled: March 21, 1997Date of Patent: October 6, 1998Assignee: Burke, Inc.Inventors: DuWayne E. Kramer, Jr., James Ernst, Jerry L. Traylor, James C. Hile
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Patent number: 5518403Abstract: A fire fighting trainer for use in training fire fighters about a ceiling rollover fire. This trainer includes a chamber with a ceiling and includes a burner head subassembly and includes a burner control subassembly. The burner head subassembly has a fuel gas inlet pipe and an adjacent combustion air inlet pipe to produce an air/gas mixture which creates a flame at the ceiling. The burner control subassembly selectively increases the fuel gas flow to make the produced flame have a ceiling rollover effect.Type: GrantFiled: March 25, 1994Date of Patent: May 21, 1996Assignee: Symtron Systems, Inc.Inventors: Steven Luftig, James Ernst, Patrick Connelly, Steven Williamson
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Patent number: 4861270Abstract: A fire fighting trainer for use in training fire fighters is provided. The fire fighting trainer includes a structure having a plurality of chambers. Each chamber contains real or simulated items, which are chosen from a group of items, such as furniture and fixtures and equipment. The trainer also includes a smoke generating system having a smoke generator and a smoke conduit. The smoke conduit has a smoke line with an outlet for each chamber. The trainer also includes a propane gas flame generating system having at least one propane gas pressure controller and a propane gas conduit. The propane gas conduit has a gas line with a burner control and a burner for each chamber. The trainer has a main control panel for regulating the flame generating system and the smoke generating system and for controlling the flame and smoke in each chamber.Type: GrantFiled: August 30, 1988Date of Patent: August 29, 1989Assignee: Symtron Systems, Inc.Inventors: James Ernst, Steven Williamson, George Rogers, Dominick Musto