Patents by Inventor JAMES F. CASELLA

JAMES F. CASELLA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aptamers for the treatment of sickle cell disease
    Patent number: 11214804
    Abstract: The present invention provides polynucleotide aptamers that selectively bind to and inhibit polymerization of sickle hemoglobin (HbS), pharmaceutical compositions comprising the same, methods of use for diagnostics and treatment of sickle cell disease, methods of use as capture reagents, and methods of rational drug design.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: January 4, 2022
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: James F. Casella, Emily Barron-Casella, Jeffrey R. Keefer, Yolanda Fortenberry, Shirley H. Purvis
  • APTAMERS FOR THE TREATMENT OF SICKLE CELL DISEASE
    Publication number: 20200332295
    Abstract: The present invention provides polynucleotide aptamers that selectively bind to and inhibit polymerization of sickle hemoglobin (HbS), pharmaceutical compositions comprising the same, methods of use for diagnostics and treatment of sickle cell disease, methods of use as capture reagents, and methods of rational drug design.
    Type: Application
    Filed: December 17, 2019
    Publication date: October 22, 2020
    Inventors: James F. Casella, Emily Barron-Casella, Jeffrey R. Keefer, Yolanda Fortenberry, Shirley H. Purvis
  • Aptamers for the treatment of sickle cell disease
    Patent number: 10513705
    Abstract: The present invention provides polynucleotide aptamers that selectively bind to and inhibit polymerization of sickle hemoglobin (HbS), pharmaceutical compositions comprising the same, methods of use for diagnostics and treatment of sickle cell disease, methods of use as capture reagents, and methods of rational drug design.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: December 24, 2019
    Assignee: The Johns Hopkins University
    Inventors: James F. Casella, Emily Barron-Casella, Jeffrey R. Keefer, Yolanda Fortenberry, Shirley H. Purvis
  • APTAMERS REDUCE SICKLE HEMOGLOBIN POLYMERIZATION
    Publication number: 20190307784
    Abstract: The presently disclosed subject matter provides methods for reducing sickling of an erythrocyte comprising sickle hemoglobin (HbS) by introducing polynucleotide aptamers into the erythrocyte. The polynucleotide aptamers specifically bind to HbS to inhibit polymerization of the HbS without affecting the oxygen affinity of the HbS.
    Type: Application
    Filed: March 30, 2017
    Publication date: October 10, 2019
    Inventors: James F. Casella, Emily Barron-Casella, Jeffrey R. Keefer, Yolanda Fortenberry, Shirley H. Purvis
  • APTAMERS FOR THE TREATMENT OF SICKLE CELL DISEASE
    Publication number: 20180282729
    Abstract: The present invention provides polynucleotide aptamers that selectively bind to and inhibit polymerization of sickle hemoglobin (HbS), pharmaceutical compositions comprising the same, methods of use for diagnostics and treatment of sickle cell disease, methods of use as capture reagents, and methods of rational drug design.
    Type: Application
    Filed: March 16, 2018
    Publication date: October 4, 2018
    Inventors: James F. Casella, Emily Barron-Casella, Jeffrey R. Keefer, Yolanda Fortenberry, Shirley H. Purvis
  • APTAMERS FOR THE TREATMENT OF SICKLE CELL DISEASE
    Publication number: 20160130585
    Abstract: The present invention provides polynucleotide aptamers that selectively bind to and inhibit polymerization of sickle hemoglobin (HbS), pharmaceutical compositions comprising the same, methods of use for diagnostics and treatment of sickle cell disease, methods of use as capture reagents, and methods of rational drug design.
    Type: Application
    Filed: May 27, 2014
    Publication date: May 12, 2016
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: JAMES F. CASELLA, EMILY BARRON-CASELLA, JEFFREY R. KEEFER, YOLANDA FORTENBERRY, SHIRLEY H. PURVIS