Patents by Inventor James F. Collawn

James F. Collawn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATING PROTEIN FOLDING DISORDERS WITH SMALL MOLECULE CFTR CORRECTORS
    Publication number: 20140073632
    Abstract: Novel CFTR corrector compounds that are effective in rescuing halide efflux in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of screening for CFTR corrector compounds are also described herein. The methods of screening include contacting a cell that endogenously expresses a CFTR mutation with the compound to be screened and detecting a rescue of halide efflux from the cell.
    Type: Application
    Filed: May 17, 2012
    Publication date: March 13, 2014
    Applicants: THE UAB RESEARCH FOUNDATION, DISCOVERYBIOMED INC.
    Inventors: Erik M. Schwiebert, James F. Collawn, Zsuzsa Bebok
  • RECEPTOR-MEDIATED UPTAKE OF PEPTIDES THAT BIND THE HUMAN TRANSFERRIN RECEPTOR
    Publication number: 20080166293
    Abstract: Peptides have been discovered which are capable of binding to and internalizing with the human transferrin receptor (hTfR). The sequences HAIYPRH (Seq. ID No. 1) and THRPPMWSPVWP (Seq. ID No. 2) are capable of binding to and internalizing with the human transferrin receptor. When these molecules were fused with other molecules, the fusion product was internalized in cells expressing hTfR. The sequences have use for targeting other peptides and proteins into cells expressing hTfR.
    Type: Application
    Filed: February 18, 2008
    Publication date: July 10, 2008
    Inventors: Jeffrey A. Engler, Jae Hwy Lee, James F. Collawn, Bryan A. Moore
  • Receptor-mediated uptake of peptides that bind the human transferrin receptor
    Patent number: 6743893
    Abstract: Peptides have been discovered which are capable of binding to and internalizing with the human transferrin receptor (hTfR). The sequences HAIYPRH (Seq. ID No. 1) and THRPPMWSPVWP (Seq. ID No. 2) are capable of binding to and internalizing with the human transferrin receptor. When these molecules were fused with other molecules, the fusion product was internalized in cells expressing hTfR. The sequences have use for targeting other peptides and proteins into cells expressing hTfR.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: June 1, 2004
    Assignee: The UAB Research Foundation
    Inventors: Jeffrey A. Engler, Jae Hwy Lee, James F. Collawn, Bryan A. Moore
  • Receptor-mediated uptake of peptides that bind the human transferrin receptor
    Publication number: 20020115824
    Abstract: Peptides have been discovered which are capable of binding to and internalizing with the human transferrin receptor (hTfR). The sequences HAIYPRH (Seq. ID No. 1) and THRPPMWSPVWP (Seq. ID No. 2) are capable of binding to and internalizing with the human transferrin receptor. When these molecules were fused with other molecules, the fusion product was internalized in cells expressing hTfR. The sequences have use for targeting other peptides and proteins into cells expressing hTfR.
    Type: Application
    Filed: November 29, 2001
    Publication date: August 22, 2002
    Inventors: Jeffrey A. Engler, Jae Hwy Lee, James F. Collawn, Bryan A. Moore