Patents by Inventor James F. Cooper

James F. Cooper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for the detection of bacterial endotoxins
    Publication number: 20030104501
    Abstract: The invention provides methods and compositions for the detection and/or quantification of bacterial endotoxins. In particular, provided herein is an inexpensive and reproducible method for producing an improved amebocyte lysate preparation having reduced Factor G activity. Provided also is an endotoxin-specific amebocyte lysate preparation produced by such a method. In addition, the invention provides methods and compositions for enhancing the sensitivity to endotoxins of amebocyte lysate preparations having reducing Factor G activity. In particular, the sensitivity of such amebocyte lysate preparations to endotoxins can be enhanced by the addition of exogenous (1→3) &bgr;-D-glucan.
    Type: Application
    Filed: April 26, 2002
    Publication date: June 5, 2003
    Applicant: Charles River Laboratories
    Inventors: Foster T. Jordan, Hui-Ti Chiang, James F. Cooper, Norman R. Wainwright
  • Methods and compositions for the detection of bacterial endotoxins
    Patent number: 6391570
    Abstract: The invention provides methods and compositions for the detection and/or quantification of bacterial endotoxins. In particular, provided herein is an inexpensive and reproducible method for producing an improved amebocyte lysate preparation having reduced Factor G activity. Provided also is an endotoxin-specific amebocyte lysate preparation produced by such a method. In addition, the invention provides methods and compositions akin for enhancing the sensitivity to endotoxins of amebocyte lysate preparations having reducing Factor G activity. In particular, the sensitivity of such amebocyte lysate preparations to endotoxins can be enhanced by the addition of exogenous (1→3) &bgr;-D-glucan.
    Type: Grant
    Filed: September 18, 2000
    Date of Patent: May 21, 2002
    Assignee: Charles River Laboratories
    Inventors: Foster T. Jordan, Hui-Ti Chiang, James F. Cooper, Norman R. Wainwright
  • Methods and compositions for the detection of bacterial endotoxins
    Patent number: 6270982
    Abstract: The invention provides methods and compositions for the detection and/or quantification of bacterial endotoxins. In particular, provided herein is an inexpensive and reproducible method for producing an improved amebocyte lysate preparation having reduced Factor G activity. Provided also is an endotoxin-specific amebocyte lysate preparation produced by such a method. In addition, the invention provides methods and compositions for enhancing the sensitivity to endotoxins of amebocyte lysate preparations having reducing Factor G activity. In particular, the sensitivity of such amebocyte lysate preparations to endotoxins can be enhanced by the addition of exogenous (1→3) &bgr;-D-glucan.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: August 7, 2001
    Assignee: Charles River Laboratories
    Inventors: Foster T. Jordan, Hui-Ti Chiang, James F. Cooper, Norman R. Wainwright