Patents by Inventor James F. Drake

James F. Drake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10137219
    Abstract: An absorbent layer for moderating blood flow from a wound has a non-woven fabric layer of water-insoluble chitosan fibers having a coating of water-absorbent starch on at least one face of the fabric layer. The coating of water-absorbent starch penetrates into the fabric layer from a first surface over the chitosan fibers to a depth of at least 25% of the fabric layer of chitosan fibers. The chitosan fibers have average diameters of from 5 to 30 micrometers. The average weight of starch/chitosan may decrease from the first surface from which the starch has penetrated into the fabric to the depth of at least 50% of the fabric layer. The starch may be modified to include hydrophilic groups into or onto molecular chains of the starch.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: November 27, 2018
    Inventor: James F. Drake
  • Patent number: 9598504
    Abstract: A process of making low-endotoxin chitosan or alkali-stable polysaccharide is performed by suspending bulk chitosan fibers or flakes or alkali-stable polysaccharide to form a reaction mixture in an aqueous solution of alcohol. Ammonia is the added to the reaction mixture to raise pH of the reaction mixture to above 9.5. The reactive mixture with a pH above 9.5 is heated at a temperature of at least 130° C. for at least 20 minutes. The heated reaction mixture is cooled to less than 60° C. and then sparged with an inert gas to remove ammonia. Separating the chitosan or alkali-stable polysaccharide from the sparged reaction mixture. The chitosan fibers or polysaccharide is rinsed with an endotoxin-free aqueous liquid to form a rinsed fiber mass. The rinsed fiber mass is further rinsed with an alcohol to remove water, and dried at a temperature below 100° C. to form the low-endotoxin chitosan or alkali-stable polysaccharide.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: March 21, 2017
    Assignee: CHITOGEN INC.
    Inventors: James F. Drake, David R. Senogles
  • Publication number: 20160168276
    Abstract: A process of making low-endotoxin chitosan or alkali-stable polysaccharide) The process may be generally performed by: suspending bulk chitosan fibers (or other suitable polysaccharide) having endotoxins therein to form a reaction mixture comprising an aqueous solution of alcohol; adding ammonia to the reaction mixture to raise pH of the reaction mixture to above 9.5; heating the reactive mixture with a pH above 9.5 at temperatures of at least 130 C for at least 20 minutes; cooling the reaction mixture to less than 60 C; sparging the cooled reaction mixture with an inert gas to remove ammonia; at least partially separating the chitosan fibers (or other suitable polysaccharide) from liquid carrier; rinsing the chitosan fibers (or other polysaccharide) with an endotoxin-free aqueous liquid to form a rinsed fiber mass; rinsing the rinsed fiber mass with an alcoholic liquid to remove water; and drying the fiber mass at a temperature below 100° C.
    Type: Application
    Filed: December 16, 2014
    Publication date: June 16, 2016
    Inventors: James F. Drake, David R. Senogles
  • Publication number: 20160030623
    Abstract: An absorbent layer for moderating blood flow from a wound has a non-woven fabric layer of water-insoluble chitosan fibers having a coating of water-absorbent starch on at least one face of the fabric layer. The coating of water-absorbent starch penetrates into the fabric layer from a first surface over the chitosan fibers to a depth of at least 25% of the fabric layer of chitosan fibers. The chitosan fibers have average diameters of from 5 to 30 micrometers. The average weight of starch/chitosan may decrease from the first surface from which the starch has penetrated into the fabric to the depth of at least 50% of the fabric layer. The starch may be modified to include hydrophilic groups into or onto molecular chains of the starch.
    Type: Application
    Filed: August 4, 2014
    Publication date: February 4, 2016
    Inventor: James F. Drake
  • Patent number: 5665363
    Abstract: A method for vaccinating an animal by implanting subcutaneously an immune stimulating biologically active material into an animal with a biologically active pellet is described. Particularly described is the method of vaccinating an animal by implanting the pellet in the ear of an animal to eliminate edible tissue damage without inducing a "drooped ear" or "down ear".
    Type: Grant
    Filed: September 3, 1996
    Date of Patent: September 9, 1997
    Assignee: InnoVac Co.
    Inventors: Richard D. Hansen, James F. Drake
  • Patent number: 4686182
    Abstract: A method of detecting a beta-lactam antibiotic in a liquid sample comprising the steps of: (a) forming a reaction medium by adding the sample to a predetermined amount of a dry reagent formulation comprising a D,D-carboxypeptidase, a substrate for said D,D-carboxypeptidase containing a carboxy-terminal D-alanine, and a reagent system which produces a color change in the presence of D-alanine; (b) incubating said reaction medium for a predetermined period; (c) adding a quenching material to terminate the reaction; (d) observing the color of the reaction medium. A kit for carrying out this method is also disclosed.
    Type: Grant
    Filed: October 17, 1984
    Date of Patent: August 11, 1987
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: James F. Drake
  • Patent number: 4664664
    Abstract: Ballistic projectiles for subsonic propulsion having a helically twisted body portion nad a tapered nose portion and having an apparent density of up to 5 g/cm.sup.3. The projectiles can be propelled through barrels having a complementary barrel without objectionable fouling.
    Type: Grant
    Filed: September 4, 1985
    Date of Patent: May 12, 1987
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: James F. Drake, Jr.
  • Patent number: 4326524
    Abstract: A solid dose ballistic projectile formed entirely of a cohesive mixture comprising biologically active material, in the form of grindable solid particles having an average diameter between about 7 and 25 micrometers, and biologically inert binder, and capable of withstanding the stresses imparted thereon when the projectile is propelled ballistically from a barrel and implanted in the flesh of a living animal.
    Type: Grant
    Filed: September 30, 1980
    Date of Patent: April 27, 1982
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: James F. Drake, Jr., G. Phillip Rambosek
  • Patent number: 4250264
    Abstract: A medium for growing bacteria from an initial population to a final predetermined population where growth of the bacteria substantially subsides due to the lack of nutrient.
    Type: Grant
    Filed: May 21, 1979
    Date of Patent: February 10, 1981
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Robert L. Nelson, James F. Drake
  • Patent number: 3948263
    Abstract: Ballistically implantable projectile adapted to carry biologically active materials into a living animal body and thereafter to provide sustained release of said biologically active material into said living animal body.
    Type: Grant
    Filed: August 14, 1974
    Date of Patent: April 6, 1976
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: James F. Drake, Jr., Fred R. Paul, Jr.