Patents by Inventor James F. Grutsch
James F. Grutsch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Diagnostic assay for the modified nucleosides pseudouridine, 7-methyladenosine, or 1-methyladenosine
Patent number: 6274314Abstract: The present invention relates to an assay for the detection of modified nucleoside levels in a patient. Detection of the modified nucleoside levels in a patient having a disease such as cancer allows for the progression of the disease to be followed and therapeutic regimens to be altered. Such an assay is particularly useful in following the response of cancer patients to chemotherapeutic treatment.Type: GrantFiled: April 2, 1998Date of Patent: August 14, 2001Assignee: Nyxis NeuroTherapies, Inc.Inventors: Joseph R. Moskal, James F. Grutsch -
Publication number: 20010000078Abstract: The present invention relates to an assay for the detection of modified nucleoside levels in a patient. Detection of the modified nucleoside levels in a patient having a disease such as cancer allows for the progression of the disease to be followed and therapeutic regimens to be altered. Such an assay is particularly useful in following the response of cancer patients to chemotherapeutic treatment.Type: ApplicationFiled: December 1, 2000Publication date: March 29, 2001Inventors: Joseph R. Moskal, James F. Grutsch
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Patent number: 5205906Abstract: A process is presented for the treatment of wastewater containing non-volatile pollutants and volatile chemically oxidizable organic and inorganic pollutants. The process combines efficient evaporation to concentrate the non-volatile compounds and a catalytic oxidation reaction to convert the volatilized organic and inorganic pollutants. A condensate product may be obtained by treating wastewater according to the inventive process that is of distilled water quality and substantially free of minerals and organics.Type: GrantFiled: February 11, 1991Date of Patent: April 27, 1993Assignee: Chemical Waste Management, Inc.Inventors: James F. Grutsch, George A. Mortimer
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Patent number: 5068036Abstract: An improved powdered adsorbent enhanced sludge process for the treatment of wastewater is disclosed that allows for in situ recovery of unregenerated powdered adsorbent. In situ recovery is performed by contacting a mixture of activated sludge and spent powdered adsorbent at disassociation conditions whereby cell lysis occurs. The cell lysis allows for physical separation of the spent powdered adsorbent from the activated sludge, thus allowing for recycle of adsorbent without the need for a regeneration process.Type: GrantFiled: March 30, 1990Date of Patent: November 26, 1991Assignee: Chemical Waste Management, Inc.Inventors: Alan Y. Li, James F. Grutsch, Kevin P. O'Leary
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Patent number: 4977839Abstract: A method for economically separating chemical contaminants such as volatile organic chemicals (VOC's) and polychlorinated biphenyls (PCB's), even if the contaminants are present at low concentrations, from inert materials such as soils or sludges, comprising subjecting inert materials contaminated with chemical compounds to a temperature effective to volatilize the contaminants but below incineration temperature, with continuous removal of evolved vapors, for a period of time sufficient to effect the desire degree of separation of contaminants. The evolved vapors may be subjected to catalytic oxidation to destroy the volatilized chemical compounds.Type: GrantFiled: June 2, 1989Date of Patent: December 18, 1990Assignee: Chemical Waste Management, Inc.Inventors: Edward G. Fochtman, Peter S. Daley, Milton Ader, Albert G. Plys, Carl P. Swanstrom, James F. Grutsch
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Patent number: 4292176Abstract: Disclosed is a process for treating waste water through the use of activated carbon. The carbon is generally added to waste water having a pH from about 4 to about 11, and is commonly added after the waste water has undergone primary treatment. Preferred modes of operation comprise using low concentrations of activated carbon having a high surface area and a zeta potential greater than about -10 millivolts. It is also preferred to use activated carbon in conjunction with an activated sludge process having an average sludge age greater than about ten days, especially where the waste water undergoes a pretreatment prior to the activated sludge process to reduce chemical oxygen demand, oil and solids content. Low concentrations of activated carbon based on feed waste water are generally used while maintaining substantially higher carbon concentrations in the process.Type: GrantFiled: August 14, 1980Date of Patent: September 29, 1981Assignee: Standard Oil Company (Indiana)Inventors: James F. Grutsch, Russell C. Mallatt
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Patent number: 4274968Abstract: Disclosed is a process for the treatment of water so as to produce water of high purity, such as potable water. The process also entails the treatment of water which may have received prior water treatment, and comprises adding an effective amount of chemical flocculant to the feed water and subjecting said water to flocculation; passing the flocculated water to a clarifier where suspended solids are separated from the partially purified water; adding about 1 to about 100 parts powdered activated carbon per million parts of water from the clarifier; contacting the water with said carbon in a reaction zone so as to achieve substantial reduction of contaminants in the water; separating the activated carbon from the purified water; and recycling a portion of the separated activated carbon to the clarifier effluent.Type: GrantFiled: June 15, 1977Date of Patent: June 23, 1981Assignee: Standard Oil Company (Indiana)Inventors: James F. Grutsch, Russell C. Mallatt, Joe D. Walk
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Patent number: 4172781Abstract: Disclosed is a waste water process for the treatment of strong wastes.Type: GrantFiled: June 15, 1977Date of Patent: October 30, 1979Assignee: Standard Oil Company (Indiana)Inventors: Joe D. Walk, James F. Grutsch, Russell C. Mallatt
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Patent number: 4168228Abstract: Disclosed is an improved process for the treatment and purification of waste water. Generally the process comprises the use of primary, intermediate, and secondary treatment but tertiary treatment may also be included. Powdered activated carbon is used in the secondary treatment with recycle to any or all of the primary, intermediate or secondary treatment stages. Regeneration of used powdered activated carbon is also provided.Type: GrantFiled: June 15, 1977Date of Patent: September 18, 1979Assignee: Standard Oil Company of IndianaInventors: Russell C. Mallatt, Joe D. Walk, James F. Grutsch
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Patent number: 4104163Abstract: This application is directed to the regeneration of fixed bed granular media filters used for the clarification of liquids, after said filters have become unsuitable or inefficient due to the occlusion of oily substances. One such regeneration method comprises the steps of: backwashing the filter, draining the filter, contacting the filter with an aqueous alkali solution composed of sodium hydroxide dissolved in demineralized water, said solution having a pH value of about 10.5 or greater, at a temperature ranging from about ambient to about 200.degree. F, for a time sufficient to regenerate the filter, and backwashing the filter. Generally, the alkali solution comprises about 0.1 to about 50 weight percent aqueous sodium hydroxide and the contacting is conducted for a period of about 0.1 to about 10 hours.Type: GrantFiled: February 24, 1977Date of Patent: August 1, 1978Assignee: Standard Oil Company a corporation of IndianaInventor: James F. Grutsch
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Patent number: 4073722Abstract: Disclosed is a continuous process for purifying contaminated waste water. First the water passes through an equalization zone including at least two separate compartments, in one of which the pH of the water is adjusted to a range of from about 6.5 to 9.5. The water flows through the separate compartments such that the concentration of contaminants in the water exiting the equalization zone will approach about constant concentration which changes only gradually even though influent contaminant concentration changes rapidly. Water in at least one compartment of the equalization zone is aerated so that the dissolved oxygen in the water is at least three parts of dissolved oxygen per million parts of water. Solids are skimmed from the surface of the water in the zone, and coagulant is added to the effluent water from the equalization zone so that colloidal particles in the water flocculate. The water from this equalization zone is then filtered to remove flocculated particles.Type: GrantFiled: February 12, 1976Date of Patent: February 14, 1978Assignee: Standard Oil Company (Indiana)Inventors: James F. Grutsch, Russell C. Mallatt, Benjamin F. Steely