Patents by Inventor James F. Matthaei

James F. Matthaei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR STIMULATION OF CHIMERIC ANTIGEN RECEPTOR T CELLS WITH HAPTEN LABELLED CELLS
    Publication number: 20230172981
    Abstract: Some embodiments of the methods and compositions provided herein relate to the use of hapten labeled cells to stimulate chimeric antigen receptor (CAR) T cells. In some embodiments, CAR T cells can include a CAR that specifically binds to a hapten. Some embodiments relate to the in vivo or in vitro stimulation CAR T cells by hapten labeled cells.
    Type: Application
    Filed: February 2, 2021
    Publication date: June 8, 2023
    Inventors: Michael C. Jensen, James F. Matthaei
  • ANTI-DINITROPHENOL CHIMERIC ANTIGEN RECEPTORS
    Publication number: 20230068879
    Abstract: Embodiments provided herein include methods and compositions comprising anti-dinitrophenol chimeric antigen receptors (CARs). Some embodiments include nucleic acids encoding such CARs, polypeptides encoded by such nucleic acids, cells comprising such nucleic acids or polypeptides, and methods utilizing such cells. Some embodiments also include the use of dinitrophenol (DNP) and derivatives thereof.
    Type: Application
    Filed: February 2, 2021
    Publication date: March 2, 2023
    Inventors: Michael C. Jensen, James F. Matthaei, Joseph K. Cheng
  • METHODS AND COMPOSITIONS FOR STIMULATION OF CHIMERIC ANTIGEN RECEPTOR T CELLS WITH HAPTEN LABELLED CELLS
    Publication number: 20210317407
    Abstract: Some embodiments of the methods and compositions provided herein relate to the use of hapten labeled cells to stimulate chimeric antigen receptor (CAR) T cells. In some embodiments, CAR T cells can include a CAR that specifically binds to a hapten. Some embodiments relate to the in vivo or in vitro stimulation CAR T cells by hapten labeled cells.
    Type: Application
    Filed: August 2, 2019
    Publication date: October 14, 2021
    Inventors: Michael C. Jensen, James F. Matthaei
  • FLUORESCEIN-SPECIFIC CARS EXHIBITING OPTIMAL T CELL FUNCTION AGAINST FL-PLE LABELLED TUMORS
    Publication number: 20200354477
    Abstract: Aspects described herein pertain to engineered chimeric antigen receptors (CARs) and compositions thereof having specificity and affinity for fluorescein containing ligands presented on the surface of tumor cells. Also provided herein are compositions including CARs further comprising a spacer arm and methods of making and using these compositions.
    Type: Application
    Filed: January 17, 2019
    Publication date: November 12, 2020
    Inventors: Michael C. Jensen, James F. Matthaei