Abstract: Embodiments for headwear are disclosed herein. In one embodiment, a headwear includes a crown, a chin strap coupled to the crown, the chin strap having a first strap portion and a second strap portion, and a set of fasteners to which one or more different components are configured to removably attach, the set of fasteners including a first fastener positioned on the first strap portion of the chin strap and a second fastener positioned on the second strap portion of the chin strap.

Abstract: A method of monitoring neural activity responsive to a stimulus in a brain, the method comprising: applying the stimulus to one or more of at least one electrode implanted in a target neural structure of the brain; detecting a resonant response from the target neural structure evoked by the stimulus at one or more of the at least one electrode in or near the target neural structure of the brain; and determining one or more waveform characteristics of the detected resonant response.

Abstract: A method of neurostimulation includes applying a probe signal to an electrode implanted in or near a target neural structure of the brain. The method further includes detecting a first response from the target neural structure evoked by the probe signal and determining a first time period between application of the probe signal and a first temporal feature of the response. Further, the method includes generating a therapeutic signal comprising a plurality of pulses, at least two of the plurality of pulses separated by the first time period, and applying the therapeutic signal to the electrode or another electrode implanted in or near the target neural structure.

Abstract: Methods and systems are disclosed for modulating glycaemia in a patient in which an activating stimulation signal is applied at an activating location at the vagus nerve, the activating stimulation signal configured to evoke a neural response in the vagus nerve; and a blocking stimulation signal is applied at a blocking location at the vagus nerve, the blocking stimulation signal configured to inhibit transmission of the evoked neural response along the vagus nerve past the blocking location; to produce unidirectional vagal nerve stimulation, the unidirectional vagal nerve stimulation being effective to modulate glycaemia in the patient.

Abstract: A method of detecting neural activity in a nerve is disclosed. A first electrical signal is received from a first pair of electrodes. A second electrical signal is received from a second pair of electrodes, the second pair of electrodes being spaced from the first pair of electrodes along the nerve. A correlation analysis is applied between the first and second electrical signals, including for at least one non-zero lag time, to obtain correlation data. From the correlation data, at least one neural signal is detected, indicative of neural activity in the nerve. The neural signal corresponds to increased correlation between the first and second signals at the at least one non-zero lag time.

Abstract: Disclosed is a method for stimulating neural tissue, where the neural tissue includes one or more neurons genetically modified to express a light-sensitive protein. The method comprises applying a light stimulus and an electrical stimulus to the neural tissue, thereby triggering membrane depolarisation in at least one of the neurons. Also disclosed is an apparatus for applying the disclosed method. The apparatus includes a light-stimulation device for selectively applying a light stimulus and an electrical-stimulation device for selectively applying an electrical stimulus to the neural tissue.

Abstract: The present disclosure relates to a peripheral nerve electrode array that includes a first, second and third pair of electrodes spaced from each other along a longitudinal axis of the electrode array, the second pair of electrodes being located between the first and third pairs of electrodes. The present disclosure further relates to method for treating or preventing a chronic inflammatory condition in a human subject in need thereof, comprising providing to the human subject a therapeutically effective electrical stimulation of the anterior central abdominal vagus nerve or the posterior central abdominal vagus nerve, wherein the electrical stimulation is provided through two or more previously implanted electrodes at a site below the cardiac branches and above the hepatic-celiac branches of the nerve; and whereby the chronic inflammatory condition is prevented or treated in the human subject.

Abstract: A method includes applying a plurality of electrical stimuli having differing amplitudes at a first position in a brain of a patient. The method further includes, for each of the plurality of electrical stimuli, detecting a resonant response from a target neural structure in the brain, each resonant response evoked by a respective one of the electrical stimuli. The method also includes determining a change in one or more common waveform characteristics between two or more of the detected resonant responses and determining an effectiveness in delivering therapeutic stimulation at the first position based on the change.

Abstract: A method for monitoring neural activity responsive to a stimulus in a brain includes applying a first stimulus to at least one electrode implanted in the brain. The first stimulus includes a first plurality of bursts of stimulation. The method also includes detecting high frequency oscillations (HFOs) between about 200 Hz and about 500 Hz due to neuronal activity at one or more of the at least one electrode implanted in the brain at least partially during application of the first stimulus, and determining one or more waveform characteristics of the HFOs. The method further includes generating a second stimulus comprising a second plurality of bursts of stimulation, wherein one or more waveform characteristics of the second stimulus is dependent on the one of more waveform characteristics of the HFOs, and applying the second stimulus to one or more of the at least one electrode implanted in the brain.

Abstract: A method for monitoring neural activity responsive to a stimulus in a brain, the method comprising: a. applying a first stimulus to one or more of at least one electrode implanted in the brain, the first stimulus comprising a first plurality of bursts of stimulation, b. detecting high frequency oscillations (HFOs) between about 200 Hz and about 500 Hz due to neuronal activity at one or more of the at least one electrode implanted in the brain at least partially during application of the first stimulus; c. determining one or more waveform characteristics of the HFOs; and d. generating a second stimulus comprising a second plurality of bursts of stimulation, wherein one or more waveform characteristics of the second stimulus is dependent on the one of more waveform characteristics of the HFOs; and e. applying the second stimulus to one or more of the at least one electrode implanted in the brain.

Abstract: Compositions and methods of using the compositions for wound healing are provided. The compositions include one or more digestive enzymes, for example, one or more protease, lipases, and amylases. The compositions can be formulated as topical pharmaceutical compositions and can be used for faster healing through stimulation of epidermal cells in the absence of scarring. The compositions may deposit a short-term fibrosis and help prevent re-opening of wounds. The compositions may improve recruitment of white blood cells, thereby inducing or enhancing growth factor and immune system activation via an enzyme antibiotic effect. The compositions may enhance the epidermal integrity beyond that of the normal physiological restorative process. Application of the compositions may result in greater re-growth of hair on regions of wounds healed with enzyme and reduced alopecia. The compositions may be administered without causing allergic reactions and without causing biological damage or burns.

Abstract: A method of monitoring neural activity responsive to a stimulus in a brain, the method comprising: applying the stimulus to one or more of at least one electrode implanted in a target neural structure of the brain; detecting a resonant response from the target neural structure evoked by the stimulus at one or more of the at least one electrode in or near the target neural structure of the brain; and determining one or more waveform characteristics of the detected resonant response.

Abstract: The present disclosure relates to a peripheral nerve electrode array that includes a first, second and third pair of electrodes spaced from each other along a longitudinal axis of the electrode array, the second pair of electrodes being located between the first and third pairs of electrodes. The present disclosure further relates to method for treating or preventing a chronic inflammatory condition in a human subject in need thereof, comprising providing to the human subject a therapeutically effective electrical stimulation of the anterior central abdominal vagus nerve or the posterior central abdominal vagus nerve, wherein the electrical stimulation is provided through two or more previously implanted electrodes at a site below the cardiac branches and above the hepatic-celiac branches of the nerve; and whereby the chronic inflammatory condition is prevented or treated in the human subject.

Abstract: A method of monitoring neural activity responsive to a stimulus in a brain, the method comprising: applying the stimulus to one or more of at least one electrode implanted in a target neural structure of the brain; detecting a resonant response from the target neural structure evoked by the stimulus at one or more of the at least one electrode in or near the target neural structure of the brain; and determining one or more waveform characteristics of the detected resonant response.

Abstract: A method of monitoring neural activity responsive to a stimulus in a brain, the method comprising: applying the stimulus to one or more of at least one electrode implanted in a target neural structure of the brain; detecting a resonant response from the target neural structure evoked by the stimulus at one or more of the at least one electrode in or near the target neural structure of the brain; and determining one or more waveform characteristics of the detected resonant response.

Abstract: Described herein are compositions which include digestive enzymes which are formulated to reduce one or more symptoms of a neuropsychiatric disorder. Also described herein is a method for treating an individual with a neuropsychiatric disorder using digestive enzymes and their derivatives to alleviate the symptoms of neuropsychiatric disorders. The method comprises administering to the individual an effective amount of digestive enzymes that are either naturally- or recombinantly-derived, or their derivatives, in an amount effective to reduce one or more symptoms of the neuropsychiatric disorder.

Abstract: Disclosed in this application are compositions which include digestive enzymes and which are formulated to reduce one or more symptoms of Schizophrenia or a Schizophreniform Disorder. Also disclosed is a method for treating an individual with Schizophrenia or a Schizophreniform Disorder using digestive enzymes and their derivatives to alleviate the symptoms of Schizophrenia or a Schizophreniform Disorder. The method comprises administering to the individual an effective amount of digestive enzymes that are either naturally or recombinantly derived, or their derivatives, in an amount effective to reduce one or more symptoms of Schizophrenia or a Schizophreniform Disorder.

Abstract: Turbomachinery comprising a turbine housing (200) with an engagement formation (210) and a casing (400) for electrical machinery, the casing (400) including an engagement recess (410). Furthermore, the engagement recess (410) comprises a cantilever member (420) and is adapted to receive the engagement formation (210). Finally, the engagement recess (410) and engagement portion (210) are configured such that during operation of said turbomachinery the engagement formation undergoes thermal expansion to expand relative to the engagement recess and exert pressure on the cantilever (member 420). In this way, an improved apparatus for centralising the turbine housing (200) in relation to the casing (400) is provided.

Abstract: This disclosure relates to the prevention and treatment of Influenza, and more particularly Influenza A Virus Subtype H1N1, with the use of a pharmaceutical composition comprising one or more digestive enzymes, such as pancreatic enzymes and porcine pancreatic enzymes. The disclosure further relates to the use of an individual's fecal chymotrypsin level as an indicator, e.g., biomarker of whether an individual may be more susceptible to Influenza, e.g., Influenza A Subtype H1N1, and/or whether an individual will benefit from administration of the described pharmaceutical compositions. Use of the compositions as sanitizers, antiseptics, disinfectants, and detergents, e.g., to reduce or eradicate influenza virus present on living or inanimate surfaces is also contemplated.

Abstract: The present disclosure relates to a peripheral nerve electrode array that includes a first, second and third pair of electrodes spaced from each other along a longitudinal axis of the electrode array, the second pair of electrodes being located between the first and third pairs of electrodes. The present disclosure further relates to method for treating or preventing a chronic inflammatory condition in a human subject in need thereof, comprising providing to the human subject a therapeutically effective electrical stimulation of the anterior central abdominal vagus nerve or the posterior central abdominal vagus nerve, wherein the electrical stimulation is provided through two or more previously implanted electrodes at a site below the cardiac branches and above the hepatic-celiac branches of the nerve; and whereby the chronic inflammatory condition is prevented or treated in the human subject.