Patents by Inventor James Farina
James Farina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11661258Abstract: A packaging system that maintains the free flowing characteristic of solid materials contained therein. The packaging system includes a container, a cover, a vapor permeable bag, a vapor impermeable liner and at least two desiccant snakes. The vapor permeable bag has an opening for receiving solid materials and is formed from cloth or continuous fibers of high-density polyethylene that are randomly distributed and non-directional. The vapor impermeable liner surrounds the vapor permeable bag and provides a moisture barrier. The desiccant snakes are disposed between the vapor permeable bag and the liner. Each snake includes two or more desiccant packages formed from a vapor permeable material through which moisture can freely pass. The desiccant packages contain clay, silica, or molecular sieves.Type: GrantFiled: April 28, 2017Date of Patent: May 30, 2023Assignee: AVANTOR PERFORMANCE MATERIALS, LLCInventors: James Farina, Nandu Deorkar
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Publication number: 20190135519Abstract: A packaging system that maintains the free flowing characteristic of solid materials contained therein. The packaging system includes a container, a cover, a vapor permeable bag, a vapor impermeable liner and at least two desiccant snakes. The vapor permeable bag has an opening for receiving solid materials and is formed from cloth or continuous fibers of high-density polyethylene that are randomly distributed and non-directional. The vapor impermeable liner surrounds the vapor permeable bag and provides a moisture barrier. The desiccant snakes are disposed between the vapor permeable bag and the liner. Each snake includes two or more desiccant packages formed from a vapor permeable material through which moisture can freely pass. The desiccant packages contain clay, silica, or molecular sieves.Type: ApplicationFiled: April 28, 2017Publication date: May 9, 2019Applicant: AVANTOR PERFORMANCE MATERIALS, LLCInventors: James Farina, Nanud Deorkar
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Publication number: 20190005534Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for generating media assets. A method includes sending a first media asset to a plurality of subscribers of a first channel of a plurality of channels. The first media asset includes a first set of media elements. The method also includes analyzing aggregated performance data associated with the first set of media elements and with the plurality of subscribers. The method further includes generating, by a computer processing device, a second media asset comprising a second set of media elements based on the aggregated performance data. The first set of media elements differs from the second set of media elements. The method further includes sending the second media asset to the plurality of subscribers.Type: ApplicationFiled: April 27, 2018Publication date: January 3, 2019Inventors: James Edward Cummings, Nicholas Dennis, Christopher James Farina
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Publication number: 20170113864Abstract: A package system for maintaining the physicochemical integrity of the contents of the package system that includes: an inner bag formed from a gas and/or moisture permeable material, an outer bag formed from an impermeable polymer material, a discharge port that provides access to the interior of the outer bag; and a desiccant or gas scavenging material. The first end of the outer bag sealingly surrounds the exterior wall of the discharge port. The second end of the inner bag is sealed closed and the desiccant or gas scavenging material is disposed in an isolated compartment. The second end of the outer bag is sealed closed to isolate the interior from the environment exterior to the package system.Type: ApplicationFiled: March 27, 2015Publication date: April 27, 2017Applicant: AVANTOR PERFORMANCE MATERIALS, INC.Inventors: James Farina, Evon Bolessa, Nandu Deorkar
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Publication number: 20170112768Abstract: An improved excipient comprising substantially homogeneous particles of a compressible, high functionality granular microcrystalline cellulose based excipient is provided. The improved excipient comprises microcrystalline cellulose and a binder, and optionally a disintegrant, and is formed by spraying a homogeneous slurry of the components. The excipient provides enhanced flowability/good flow properties, excellent/high compactibility, and increased API loading and blendability as compared to the individual components, and as compared to conventional excipients formed from the same materials. The improved excipient has strong intraparticle bonding bridges between the components, resulting in a unique structural morphology including significant open structures or hollow pores. The presence of these pores provides a surface roughness that is the ideal environment for improved blending with an API.Type: ApplicationFiled: January 4, 2017Publication date: April 27, 2017Applicant: AVANTOR PERFORMANCE MATERIALS, LLCInventors: Nandu DEORKAR, James FARINA, Liliana MIINEA, Sameer RANDIVE
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Publication number: 20120100211Abstract: A low dose API pharmaceutical tablet having excellent content uniformity is provided. The tablet is formed by spray coating a support excipient with the API. The resulting composition is suitable for direct compression tablet formulation without the need for an additional granulation step to uniformly coat the API onto the support excipient. The support excipient comprises microcrystalline cellulose, a binder and a disintegrant, and is formed by spraying a homogeneous slurry of the support excipient components.Type: ApplicationFiled: July 12, 2010Publication date: April 26, 2012Inventors: James Farina, Nandu Deorkar, Liliana Miinea
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Publication number: 20110288146Abstract: An improved excipient comprising substantially homogeneous particles of a compressible, high functionality granular microcrystalline cellulose based excipient is provided. The improved excipient comprises microcrystalline cellulose and a binder, and optionally a disintegrant, and is formed by spraying a homogeneous slurry of the components. The excipient provides enhanced flowability/good flow properties, excellent/high compactibility, and increased API loading and blendability as compared to the individual components, and as compared to conventional excipients formed from the same materials. The improved excipient has strong intraparticle bonding bridges between the components, resulting in a unique structural morphology including significant open structures or hollow pores. The presence of these pores provides a surface roughness that is the ideal environment for improved blending with an API.Type: ApplicationFiled: November 16, 2009Publication date: November 24, 2011Inventors: Nandu Deorkar, James Farina, Liliana Miinea, Sameer Ranadive
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Publication number: 20110229527Abstract: An improved excipient comprising substantially homogeneous particles of a compressible, high functionality granular dibasic calcium phosphate based excipient is provided. The improved excipient comprises dibasic calcium phosphate, a binder and a disintegrant, and is formed by spraying a homogeneous slurry of the components. The improved excipient provides enhanced flowability/good flow properties, an increased API loading and blendability and higher compactibility as compared to the individual components, and as compared to excipients formed from the same materials by conventional methods. The improved excipient has strong intraparticle bonding bridges between the components, resulting in a unique structural morphology including significant open structures or hollow pores. The presence of these pores provides a surface roughness that is the ideal environment for improved blending with an API.Type: ApplicationFiled: November 13, 2009Publication date: September 22, 2011Inventors: Nandu Deorkar, James Farina, Liliana Miinea, Sameer Randive
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Publication number: 20110136921Abstract: A sustained release composition comprising spray dried particles of at least one polysaccharide gum and at least one polyhydric sugar alcohol, as well as methods of making the sustained released composition are provided. A sustained release pharmaceutical solid dosage form, and a method of making the solid dosage form by compression are also provided.Type: ApplicationFiled: August 6, 2009Publication date: June 9, 2011Inventors: Nilesh Tanhaji Dumbre, Amelia Makarand Avachat, Nandu Deorkar, James Farina, Liliana Miinea
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Publication number: 20110092598Abstract: An improved excipient comprising substantially homogeneous particles of a compressible, high functionality granular microcrystalline cellulose based excipient is provided. The improved excipient comprises microcrystalline cellulose, a binder and a disintegrant, and is formed by spraying a homogeneous slurry of the components. The excipient provides enhanced flowability/good flow properties, excellent/high compactibility, and increased API loading and blendability as compared to the individual components, and as compared to conventional excipients formed from the same materials. The improved excipient has strong intraparticle bonding bridges between the components, resulting in a unique structural morphology including significant open structures or hollow pores. The presence of these pores provides a surface roughness that is the ideal environment for improved blending with an API.Type: ApplicationFiled: October 7, 2008Publication date: April 21, 2011Inventors: Nandu Deorkar, James Farina, Liliana Miinea, Sameer Randive
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Publication number: 20100055180Abstract: An improved excipient comprising substantially homogeneous particles of a compressible, high functionality granular microcrystalline cellulose based excipient is provided. The improved excipient comprises microcrystalline cellulose and a binder, and optionally a disintegrant, and is formed by spraying a homogeneous slurry of the components. The excipient provides enhanced flowability/good flow properties, excellent/high compactibility, and increased API loading and blendability as compared to the individual components, and as compared to conventional excipients formed from the same materials. The improved excipient has strong intraparticle bonding bridges between the components, resulting in a unique structural morphology including significant open structures or hollow pores. The presence of these pores provides a surface roughness that is the ideal environment for improved blending with an API.Type: ApplicationFiled: November 16, 2009Publication date: March 4, 2010Applicant: Mallinckrodt Baker, Inc.Inventors: Nandu Deorkar, James Farina, Liliana Miinea, Sameer Randive
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Publication number: 20070175537Abstract: This invention relates to a system or apparatus (10) and a method for dispensing a material (16) from a pressurized container (12) while maintaining product integrity. The system or apparatus comprises a pressurized container for holding the material and having a dispensing valve (20) provided with a dispensing conduit or stem (26) for dispensing the material from the container at the appropriate time, a syringe (42) equipped with an on/off locking mechanism (48) for permitting or preventing flow of the material into and out of the syringe by way of a stem or conduit (50) attached to the locking mechanism, and a removable adaptor (34) for connecting the stem of the syringe to the stem of the dispensing valve of the pressurized container for permitting flow of material from the pressurized container into a chamber of the syringe upon actuation of the dispensing valve.Type: ApplicationFiled: June 15, 2005Publication date: August 2, 2007Inventor: James Farina
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Publication number: 20070129541Abstract: A scalable process for the preparation of a rapamycin 42-ester by reacting a rapamycin 42-ester boronate with a diol and purifying crude rapamycin 42-ester by recrystallization and treatment with a diol is provided. Also provided is a method for isolating and purifying a rapamycin 42-ester boronate from mother liquors comprising acetone and rapamycin contaminants.Type: ApplicationFiled: December 6, 2006Publication date: June 7, 2007Applicant: WyethInventors: Chunhao Zhang, Clifford Coughlin, Anthony Pilcher, Adam Michaud, James Farina, Ayman Sahli
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Publication number: 20060135869Abstract: A system and method for improving the examination of vessel walls through fluid using near infrared (NIR) spectroscopy by employing a parallel measurement where all wavelengths are measured simultaneously. The system and method of the present invention obviates that need to attempt to overcome the motion of a catheter by complex filtering or averaging over time by performing the measurements for each wavelength under identical conditions.Type: ApplicationFiled: December 5, 2005Publication date: June 22, 2006Inventor: James Farina
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Patent number: 6875817Abstract: Separation of a variety of analytes that are polar, nonpolar and ionic using functionalized polymeric media is disclosed. Preformed rigid particles of highly crosslinked homopolymer of polyvinylidene compounds are functionalize using the residual vinyl groups onto which monovinyl compounds are covalently bonded through polymerization. The functionalization imparts desirable surface properties for separation applications such as liquid chromatography and solid phase extraction.Type: GrantFiled: August 21, 2001Date of Patent: April 5, 2005Assignee: Mallinckrodt Inc.Inventors: Nandkumar V. Deorkar, James Farina, Paul A. Bouis
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Publication number: 20050032922Abstract: Separation of a variety of analytes that are polar, nonpolar and ionic using functionalized polymeric media is disclosed. Preformed rigid particles of highly crosslinked homopolymer of polyvinylidene compounds are functionalized using the residual vinyl groups onto which monovinyl compounds are covalently bonded through polymerization. The functionalization imparts desirable surface properties for separation applications such as liquid chromatography and solid phase extraction.Type: ApplicationFiled: August 21, 2001Publication date: February 10, 2005Inventors: Nandkumar Deorkar, James Farina, Paul Bouis