Abstract: Disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a homologous prime/boost vaccination strategy, such as adenoviral vectors for use in a homologous prime/boost vaccination strategy.

Abstract: An adaptive deception system is provided for defending a production network against cyber-attacks utilizing deception devices on the production network. The adaptive deception system includes a deception management system. The deception management system includes monitors for making observations regarding the deception devices including observations of an attacker's interaction with the deception device. The adaptive deception system further incudes a control system having sensors that receive the observations of the deception management system. The control system is configured to provide an adaption specification in response to the observations made. Actuators of the control system are activated in order to provide the adaption specification to the deception management system where monitors of the deception management system implement the specified adaption. Implementation of the adaption adapts the properties of the deception devices to interfere with the cyber-attacker.

Abstract: The present invention provides RAD51 inhibitors having the structural formula (I): or a pharmaceutically acceptable salt or solvate thereof. Also provided are methods of treating or preventing cancer comprising administration of the compounds of the present invention, as well as uses of the compounds to induce a synergistic effect with known chemotherapeutic.

Abstract: Porous, extruded titania-based materials further comprising one or more quaternary ammonium compounds and/or prepared using one or more quaternary ammonium compounds, Fischer-Tropsch catalysts comprising them, uses of the foregoing, processes for making and using the same and products obtained from such processes.

Abstract: Disclosed are examples of systems, apparatus, methods and computer program products for providing run-time querying of multi-tenant non-relational database objects. A database system maintains a multi-tenant non-relational database associated with a number of enterprises, a number of records, and a number of data objects for each of the enterprises, each data object having at least one composite key field. A request is received during runtime to query data related to a data object, and the system determines that the data object is defined to be used in associated with a non-relational database. The system then retrieves a metadata model of the data object, determines that the request includes at least one composite key field for the data object, and processes the requery to query data in synchronous fashion. Finally, a query response is provided to the user.

Abstract: Systems, methods, and computer-readable media for asynchronous (async) querying are described. In embodiments, a system may convert a user-issued query into a distributed execution instruction set (DEIS), and issue the DEIS to data stores that may have various database structures. The system may obtain database objects from the data stores, and store a result set indicating the obtained database objects in a location specified by the user-issued query. The system may also provide mechanisms to allow users to view progress of their async query jobs and/or cancel ongoing async query jobs. Other embodiments may be described and/or claimed.

Abstract: A temperature control device (2) comprises a number of active thermal sites (6) disposed at respective locations on a substrate (10), each comprising a heating element (13) for applying a variable amount of heat to a corresponding site of a medium and a thermal insulation layer (16) disposed between the heating element and the substrate. At least one passive thermal region (8) is disposed between the active thermal sites (6) on the substrate (10), each passive thermal region (8) comprising a thermal conduction layer (18) for conducting heat from a corresponding portion of the medium to the substrate (10). The thermal conduction layer (18) has a lower thermal resistance in a direction perpendicular to a plane of the substrate (10) than the thermal insulation layer (16). This enables precise control over both heating and cooling of individual sites in a flowing fluid, for example.

Abstract: This disclosure relates to methods and systems for processing of sequencing data streams. The system receives sequences from a sequencer and stores them as data records on a database. The sequences are associated with a counter indicative of a number of times the associated sequence has been sequenced. The system progressively receives a further sequence as streaming data from the sequence. While receiving the further sequence, the system matches the streaming data against the stored sequences to determine a matching score. Upon the matching score exceeding a matching threshold for one of the multiple sequences in the database, the system selects the one of the sequences in the database based on the matching score and stores the further sequence on non-volatile memory where the counter value associated with the selected sequence is below a saturation threshold. The system also terminates the receiving where the counter value is above the saturation threshold.

Abstract: Systems, apparatus, methods and computer program products for deleting data of an object within a multi-tenant database via an efficient delete operation are described herein. The new delete operation (or method) may be configured to identify one or more records to be deleted within a data structure such as an object. In order to ensure that the operation is efficient, the mechanism may determine characteristics of a data store and determine whether the information provided within the data structure provides an efficient identification of the data to be deleted. Upon a successful validation, an initial delete request may be translated to an appropriate delete operation for the underlying database.

Abstract: The present invention relates to a biological (eg cell) processing assembly comprising an aseptic chamber with apertures adapted for gloves to fit and an incubation chamber connectable to aseptic chamber with transfer hatches, doors secured by multi-walls and inflatable seals, stepped collars for tight closure of doors and closed interaction between the chambers. From the aseptic chamber it can be reached through into incubation chamber. There is a docking spigot on outlet wall to interact with stepped collar to define transfer port between the chambers and a disinfectant delivery device to disinfect transfer port.

Abstract: A locker unit comprising: a cabinet body; at least one internal mounting bracket (40) provided at each lateral side of the cabinet body; at least one horizontal panel (30) mountable to each mounting bracket (40) at a vertical height so as to define two or more vertically stacked lockers, each panel (30) comprising a side flange (32) provided at each lateral edge of the panel; and a door associated with each locker, wherein each side flange has one or more apertures which are alignable with an aperture provided at the mounting bracket for receiving a retaining member (42), and wherein each panel includes an obstructing member (50) located near to each aperture of the side flange.

Abstract: The invention provides structures, methods, and assemblies for bioretention systems, including tree box filters with one or more internal bypass features incorporated into the tree box filter. The invention also provides methods and additional structures that are useful for managing stormwater flow and inhibiting the flow of pollutants, debris, and other contaminants into drainage systems.

Abstract: Dressing or bandage for protecting a wound accidentally incurred, surgical incision deliberately made in the skin, epidermal delivery of medication, or musculotherapy of a human being or animal, said bandage/dressing having the primary characteristic of being significantly atraumatic upon removal of same by virtue of a novel stringlike member that is intentionally incorporated into or debossed into the construction of said parent bandage/dressing in a multi-spiral geometry, said stringlike member firstly being pulled gently and progressively in multiple turns around the wound site or epidermal treatment area to in effect significantly reduce the area of remaining/undisturbed adhesive between the bandage/dressing and patient's skin before the bandage/dressing is peeled away from the skin in conventional manner and thus affording the patient a significantly less traumatic experience.

Abstract: Structures, methods, and assemblies for stormwater management systems with one or more internal bypass features incorporated into a vault-shaped enclosure are described, along with methods and additional structures that are useful for managing stormwater flow and inhibiting the flow of pollutants, debris, and other contaminants into drainage systems. A first compartment disposed within the vault and comprising a removable bypass pipe, a baffle wall adjacent to the bypass pipe, a screened floatables baffle attached to the baffle wall, and a fluid-conveyance opening disposed along the baffle wall are described. A fluid-conveyance opening is located below the top of a bypass pipe, and a second compartment is in fluid communication with the first compartment through the fluid-conveyance opening. A second compartment is adapted to incorporate a filtration cartridge.

Abstract: The invention relates an aqueous coating composition comprising an acrylic polymer dissolved in a liquid phase comprising water and a water-miscible solvent, wherein the coating composition comprises at least 50 wt % water, and wherein the acrylic polymer is a film-forming polymer obtainable by free radical polymerization of a monomer mixture comprising in the range of from 30 0 to 70 wt % of a poly(ethyleneglycol) (meth)acrylic monomer a.; in the range of from 2 to 20 wt % of an alkoxysilyl or alkoxyalkylsilyl functional (meth)acrylic monomer b.; and in the range of from 10 to 68 wt % of a hydrophobic ethylenically unsaturated monomer c. The invention further relates to a substrate coated with such coating composition, to a process for controlling aquatic biofouling on a surface of a man-made object, and to use of such coating composition to control aquatic biofouling on a man-made object.

Abstract: The present disclosure relates to an improved methodology for phenotyping and molecular characterisation of single cells using high-throughput and multiplexed targeted long-read single cell sequencing. In one particular example, the present disclosure relates to a methodology which combines targeted long-read sequencing with short-read based transcriptome profiling of barcoded single cell libraries generated by droplet-based partitioning for high throughput deep single cell profiling.

Abstract: Disclosed are examples of systems, apparatus, methods and computer program products for deleting data of an object within a multi-tenant database. Described is a mechanism for performing operations such as an efficient delete operation by introducing a new delete operation (or method) that is configured to allow a data structure such as an object to identify one or more records to be deleted. In order to ensure that the operation is efficient, the mechanism may determine characteristics of a data store and determine whether the information provided within the data structure provides an efficient identification of the data to be deleted. Upon a successful validation, an initial delete request may be translated to an appropriate delete operation for the underlying database.

Abstract: A hybrid biosensing-imaging system that can operate inside an incubator, structures and methods are directed to placing modular and removable biosensors and biocompatible interfaces in 3D transparent test wells that contain biological samples. The technology enables continuous monitoring of multiple simultaneous parameters and functions of a living cell or cell clusters such as alterations of cellular ligands, physicochemical biomarkers, phenotypes, and/or extracellular compositions upon interactions with analytes or during progressions. Methods of capturing and analyzing direct orthogonal information from biological samples in 2D and 3D.