Abstract: Provided herein is a combination therapy useful for the treatment of Alzheimer's disease and Alzheimer's disease related dementia. The combination comprises memantine in an immediate or sustained release form and donepezil in a sustained release form.

Abstract: A negative ion source placed inside a negatively-charged high voltage electrode emits a beam which is accelerated to moderate energy, approximately 35,000 electron volts, and filtered by a momentum analyzer i.e. an analyzing bending magnet, to remove unwanted ions. Reference ions such as carbon-12 are deflected and measured in an off-axis Faraday cup. Ions of interest, such as carbon ions of mass 14, are accelerated through 300 kV to ground potential and passed through a gas stripper where the ions undergo charge exchange and molecular destruction. The desired isotope, carbon-14 along with fragments of the interfering molecular ions, emerge from the stripper into a momentum analyzer which removes undesirable isotope ions. The ions are further filtered by passing through an electrostatic spherical analyzer to remove ions which have undergone charge exchange. The ions remaining after the spherical analyzer are transmitted to a detector and counted.

Abstract: A negative ion source placed inside a negatively-charged high voltage terminal emits a beam which is accelerated to moderate energy, approximately 35,000 electron volts, and filtered by a momentum analyzer i.e. an analyzing bending magnet, to remove unwanted ions. Reference ions such as carbon-12 are deflected and measured in an off-axis Faraday cup. Ions of interest, such as carbon ions of mass 14, are accelerated through 300 kV to ground potential and passed through a gas stripper where the ions undergo charge exchange and molecular destruction. The desired isotope, carbon-14 along with fragments of the interfering molecular ions, emerge from the stripper into a momentum analyzer which removes undesirable isotope ions. The ions are further filtered by passing through an electrostatic spherical analyzer to remove ions which have undergone charge exchange. The ions remaining after the spherical analyzer are transmitted to a detector and counted.

Abstract: A hydrogen ion accelerator produces a beam current that is at least ten times greater than the current supplied by an electrostatic generator by recycling the unreacted portion of the beam. In one application, a 1.76 MeV proton beam is used to generate 9.172 MeV gamma rays for detecting explosives (nitrogen) via either the .sup.13 C reaction. The cross-section of the 1.76 MeV proton beam with the carbon 13 target is such that over 95 percent of the beam passes through the target unreacted. In a preferred embodiment, a proton source (52) disposed within a high voltage electrode (32) forms a proton beam that is accelerated along the length of an acceleration tube (46), is bent 180.degree. by bending magnets (70, 72), passes through a target foil (76), is decelerated along the length of a deceleration tube (82), and is returned to the high voltage electrode (32) where the energy contained in the beam is recaptured.

Abstract: An apparatus employs two spaced apart dipole magnets. An ion beam containing carbon of mass 2, 13 and 14 is focused by an Einzel lens and is directed into a first dipole magnet. The first magnet causes the beam to bend approximately 70 degrees, which separates the mass 12, 13 and 14 ions while at the same time focusing them in the X direction or deflection plane. The ions exit the first dipole magnet and pass through a blanking plate which can selectively remove one or two of the beams of mass 12, 13 and 14 ions. After leaving the first bending magnet, the mass 12 and 14 beams pass through a steering device so the trajectories of the mass 12 and 14 ions are deflected a few degrees to bring them parallel to the mass 13 ion beam. The parallel ion beams next pass through an electrostatic slot lens which focuses the beams in the direction out of the bending plane. After passing through the slot lens, the mass 12 and 14 beams are deflected in like amount to the deflection at the first steering device.