Abstract: This provides locations for mounting controllers and processing components that effectively employ the roof within a frame covered by a cowling so as to avoid exposure to weather and the environment. The roof is also employed to provide a sensor bar that extends across the vehicle width for a distance that does not interfere with normal vehicle function or generate potential overhangs, which can inadvertently engage objects or vehicles. The bar is sufficient in size and shape so as to allow mounting of a plurality of types of sensors on its top surface and/or recessed within front or rear edges. Such sensors can include visual light cameras for machine vison processes and/or LIDAR of various types and cooperage areas/fields of view—some of which can be recessed within a hollow region of the bar. Additional sensors can be mounted on the truck cab and/or chassis, including visual-light cameras and radars.

Abstract: The invention relates to therapeutic compositions for disorders associated with haploinsufficiency. The invention provides antisense oligonucleotides useful for treating neurodevelopmental disorders associated with mutations in the SYNGAP gene. The invention provides compositions that include synthetic antisense oligonucleotides (ASOs) that promote expression of the SynGAP protein by one or any combination of (i) preventing one or more miRNAs from interfering with production of the SynGAP protein; (ii) binding to the 5?-UTR of the SYNGAP1 transcript and augmenting translation of the Syngap protein; and (iii) promoting RNAseH cleavage of antisense long non-coding RNAs that are anticorrelated with SYNGAP expression. When the composition is delivered to a patient with SYNGAP haploinsufficiency, the ASOs promote expression of the SynGAP protein.

Abstract: The invention relates to therapeutic compositions for disorders associated with haploinsufficiency. The invention provides antisense oligonucleotides useful for treating early-onset epileptic encephalopathy by promoting expression of Syntaxin-binding protein 1 (STXBP1). The invention provides compositions that include synthetic antisense oligonucleotides (ASOs) that prevent certain miRNAs from interfering with production of the STXBP1 protein or bind to the 5?-UTR of the STXBP1 transcript and augment translation of the STXBP1 protein. When the composition is delivered to a patient with STXBP1 haploinsufficiency, the ASOs prevent miRNA from downregulating synthesis of STXBP1 protein.

Abstract: The invention provides compositions useful to knock down overexpression of UBE3A and treat conditions associated with Dup15q syndrome. The compositions include antisense oligonucleotides, preferably short oligonucleotides that are complementary to, and hybridize to, UBE3A transcripts in vivo. The ASOs prevent or inhibit successful translation of UBE3A mRNA into protein. Specifically, preferred embodiments include anti-UBE3A gapmers—oligos that include a central DNA portion flanked by RNA wings. When the gapmer hybridizes to UBE3A pre-mRNA or mRNA, the duplex hybrid recruits RNaseH, which cleaves, or digests, the UBE3A pre-mRNA or mRNA, preventing expression of the UBE3A protein. Because the ASOs prevent expression of the UBE3A protein, treatment with a composition including ASOs of the disclosure may be effective to knock down overexpression of UBE3A.

Abstract: Techniques for configurable event-based compute instance security assessments are described. A security assessment service receives one or more configuration messages, sent on behalf of a user, indicating a request to perform a security assessment of one or more computing resources managed by a service provider system responsive to any of one or more events being determined to have occurred. The security assessment is to include attempting to identify security vulnerabilities of the one or more computing resources. The security assessment service determines that an event of the one or more events has occurred subsequent to event data being reported that is indicative of the event, and performs the security assessment of the one or more computing resources responsive to the determining that the event has occurred.

Abstract: Techniques for configurable event-based compute instance security assessments are described. A security assessment service receives one or more configuration messages, sent on behalf of a user, indicating a request to perform a security assessment of one or more computing resources managed by a service provider system responsive to any of one or more events being determined to have occurred. The security assessment is to include attempting to identify security vulnerabilities of the one or more computing resources. The security assessment service determines that an event of the one or more events has occurred subsequent to event data being reported that is indicative of the event, and performs the security assessment of the one or more computing resources responsive to the determining that the event has occurred.

Abstract: Techniques for configurable event-based compute instance security assessments are described. A security assessment service receives one or more configuration messages, sent on behalf of a user, indicating a request to perform a security assessment of one or more computing resources managed by a service provider system responsive to any of one or more events being determined to have occurred. The security assessment is to include attempting to identify security vulnerabilities of the one or more computing resources. The security assessment service determines that an event of the one or more events has occurred subsequent to event data being reported that is indicative of the event, and performs the security assessment of the one or more computing resources responsive to the determining that the event has occurred.

Abstract: A fallback query mechanism that serves as a way to recover from query conditions (or criteria) that break due to excessively large result sets relative to a preset threshold. The fallback query mechanism detects when a query has failed to execute because the query requested more items from the database (or list) than allowed by the threshold, rewrites the query to examine no more than the threshold number of most recently created items that match one of the indexed filter criteria specified in a view, and then applies one or more of the other filter criteria. The mechanism then reruns the query and displays the results to the user.

Abstract: A nebulizer to deliver a medicament that includes a housing having a reservoir for the medicament, an aerosol generator that can be supplied the medicament from the reservoir, where the generator aerosolizes at least a portion of the medicament into an aerosol, a gas venting inlet to permit a gas to enter the nebulizer and form a mixture with the aerosol, and a passage through which the mixture of the aerosol and the gas is delivered to an outlet port of the nebulizer.

Abstract: The present invention relates to the field of boat trailers, and in particular, to boat trailers with rotatable support structures. The boat trailer includes a front end configured for hitching to a towing vehicle, a rear end, a wheel assembly disposed between the front and rear ends for rolling engagement with the ground and a support frame assembly carried on the wheel assembly. The support frame assembly has a lower base frame portion and an upper carousel frame portion superimposed on, and pivotally connected to, the base frame portion. The carousel frame portion is configured to support a boat thereon. Also provided is a support frame lifting assembly connected to the support frame assembly and the wheel assembly. The support frame lifting assembly is operable to raise at least a portion of the support frame assembly above the wheel assembly so as to permit rotation of the carousel frame portion relative to the base frame portion.

Abstract: The present invention relates to the field of boat trailers, and in particular, to boat trailers with rotatable support structures. The boat trailer includes a front end configured for hitching to a towing vehicle, a rear end, a wheel assembly disposed between the front and rear ends for rolling engagement with the ground and a support frame assembly carried on the wheel assembly. The support frame assembly has a lower base frame portion and an upper carousel frame portion superimposed on, and pivotally connected to, the base frame portion. The carousel frame portion is configured to support a boat thereon. Also provided is a support frame lifting assembly connected to the support frame assembly and the wheel assembly. The support frame lifting assembly is operable to raise at least a portion of the support frame assembly above the wheel assembly so as to permit rotation of the carousel frame portion relative to the base frame portion.

Abstract: A pressure-assisted breathing system comprises a pressure-generating circuit for maintaining a positive pressure within the system, and a patient interface device coupled to a patient's respiratory system. A respiratory circuit is positioned between the pressure-generating circuit and the patient interface device and a nebulizer is coupled to the respiratory circuit.

Abstract: A system for providing a client's credentials to a computer program comprises a database remote from the client and a single signon server module. The single signon server module can receive a request for the client's credentials from the computer program, determine whether the client's credentials are stored in the database, and send the client's credentials from the database to the computer program in response to a determination that the client's credentials are stored in the database. The single signon server module can store the client's credentials in the database in response to a determination that the client's credentials are not stored in the database. The single signon server module can encrypt the client's credentials prior to storing the client's credentials in the database and can decrypt the client's credentials prior to sending the client's credentials to the computer program.

Abstract: The present invention is a composite laminated sheet material suitable for structures such as containment sumps. The laminated material comprises a fabric-backed thermoplastic layer upon which thermoset plastic is applied to the fabric side. The thermoplastic layer is formed by contacting a layer of fabric onto a layer of molten thermoplastic such that the liquid thermoplastic permeates a portion of the fabric layer to form a mechanical bond with the fabric layer when the thermoplastic layer cools and hardens. Thermoset plastic, such as fibreglass resin, is sprayed onto the fabric side of the thermoplastic layer to allow the liquid resin to permeate the fabric layer. Once the resin cures and hardens, the fabric layer is mechanically bonded to the cured thermoset plastic layer to effectively bond the thermoplastic layer to the thermoset plastic layer.

Abstract: Systems and methods for transforming a document to a web page can include a mapping module programmed to map document styles of a document to styles of a web page. The system can also include a conversion module programmed to convert contents of the document into hypertext markup language based on the map of the mapping module, and a rendering module programmed to render the web page based on the hypertext markup language. A method can include mapping document styles in a document to styles of a web page, converting contents of the document into hypertext markup language based on the mapping, and rendering the web page based on the hypertext markup language.

Abstract: A fallback query mechanism that serves as a way to recover from query conditions (or criteria) that break due to excessively large result sets relative to a preset threshold. The fallback query mechanism detects when a query has failed to execute because the query requested more items from the database (or list) than allowed by the threshold, rewrites the query to examine no more than the threshold number of most recently created items that match one of the indexed filter criteria specified in a view, and then applies one or more of the other filter criteria. The mechanism then reruns the query and displays the results to the user.

Abstract: A system for providing a client's credentials to a computer program comprises a database remote from the client and a single signon server module. The single signon server module can receive a request for the client's credentials from the computer program, determine whether the client's credentials are stored in the database, and send the client's credentials from the database to the computer program in response to a determination that the client's credentials are stored in the database. The single signon server module can store the client's credentials in the database in response to a determination that the client's credentials are not stored in the database. The single signon server module can encrypt the client's credentials prior to storing the client's credentials in the database and can decrypt the client's credentials prior to sending the client's credentials to the computer program.

Abstract: Methods, systems and computer-readable media are provided for organizing links on a web page via drag and drop operations. Single web page links or groups of web page links may be dragged from one location on a web page to another location on a web page or to another group of links on the web page. Links may also be dragged from a first web page or first client application document and may be dropped to a second web page on a same or separate web browsing application.

Abstract: A nebulized fluid, generated by vibrating an aerosolization element, is introduced into a breathing circuit during a certain interval of a patient's breathing cycle. In some embodiments, the fluid comprises an antibiotic that is selected to treat a pulmonary infection resulting from mechanical ventilation.

Abstract: A system for restricting mixing of air in a data center includes a plurality of racks, each of the racks having a front face and a back face. The system includes an enclosure for collecting air released from the back faces of the plurality of racks, the enclosure configured to substantially contain the air in an area between the first row and the second row and having a roof panel coupled to the first row of racks and the second row of racks configured to span a distance between the first row of racks and the second row of racks. The enclosure is configured to maintain a first air pressure inside of the enclosure that is substantially equal to a second air pressure outside the enclosure.