Abstract: A respiratory treatment apparatus generates an indication of inspiration or expiration based on a measure of motor current of a flow generator. In an example, first and second current signals are derived from the measurement. The first derived current signal may be a long term measure or average of current and the second derived current signal may be a short term measure or average of current. A processor 120 determines an indication of inspiration or expiration as a function of the first and second derived current signals. The function of the first derived current signal and the second derived current signal may be a comparison of the derived current signals. The derived signals may be determined by filtering. The indication of inspiration or expiration may serve as a trigger or cycle control for changing treatment pressure in synchrony with patient respiration without measured signals from pressure, flow or speed sensors.

Abstract: An aircraft includes an aircraft heat source; a propulsion system including an electric propulsion engine, the electric propulsion engine including an electric motor and a fan rotatable by the electric motor, the electric propulsion engine further defining a fan air flowpath; a thermal management system including a heat source exchanger in thermal communication with the aircraft heat source, a heat sink exchanger in thermal communication with the fan air flowpath of the electric propulsion engine, and a thermal distribution bus extending from the heat source exchanger to the heat sink exchanger; and a control system operably connected to the thermal management system for selectively thermally coupling the heat sink exchanger with the heat source exchanger.

Abstract: The deflectable tip catheters can be used with a primary delivery system (e.g., a bronchoscope, endoscope, or other surgical access device) to access a certain target tissue, such as a tumor (e.g., a lung tumor). The primary access device provides initial access and the deflectable tip catheter can be passed through the primary access device to reach the target tissue which is not otherwise accessible by the primary access device. The deflectable tip catheters have an internal bore free of obstructions such that a drug delivery device (e.g., a needle) or a diagnostic tool can be passed therethrough to directly access the target tissue.

Abstract: A method for assisting wallet providers in regulatory compliance for blockchain transactions includes: receiving, by a receiver of a processing server, a new blockchain transaction from a first computing device, the new blockchain including at least a destination address associated with a blockchain wallet as a recipient for the new blockchain transaction; generating, by a processor of the processing server, a reference identifier for the new blockchain transaction; identifying, by the processor of the processing server, a profile for the blockchain wallet based on the destination address; transmitting, by a transmitter of the processing server, the reference identifier to the first computing device; and transmitting, by the transmitter of the processing server, a notification message to a second computing device, the notification message including at least the reference identifier and data associated with the blockchain wallet.

Abstract: A stator assembly has coils in a distributed winding configuration. A poly-phase switched reluctance motor assembly may include a stator assembly with multiple coils in a distributed winding configuration. The stator assembly may have a central bore into which a rotor assembly having multiple poles is received and configured to rotate. A method of controlling a switched reluctance motor may include at least three phases wherein during each conduction period a first phase is energized with negative direction current, a second phase is energized with positive current and there is at least one non-energized phase. During each commutation period either the first phase or second phase switches off to a non-energized state and one of the non-energized phases switches on to an energized state with the same direction current as the first or second phase that was switched off. The switched reluctance motor may include a distributed winding configuration.

Abstract: An adjustable implant is disclosed herein. The adjustable implant may comprise a shell including membrane and a base and having a first diameter in a plane parallel to the base. A band may be disposed within the shell. The band may have a first end and a second end connected to a spool. The band may be in a round (e.g., elliptical) configuration having a second diameter in the plane that is less than the first diameter. By wrapping the band onto the spool, the diameter of the band may be decreased and the height of the implant may be increased. By unwrapping the band from the spool, the diameter of the band may be increased and the height of the implant may be decreased.

Abstract: The present invention relates to antibody-drug conjugates comprising (i) an antibody or antigen-binding fragment thereof, (ii) a polymer comprising a particular repeat unit comprising an amino acid derivative, which is covalently bound to one or more biologically active moieties, such as small molecule drugs, optionally via a linker, and (iii) a polymer-antibody linker moiety which is covalently bound to both the polymer and the antibody or antigen-binding fragment thereof. Additionally, the present invention relates to pharmaceutical compositions comprising the antibody-drug conjugates and to use of the antibody-drug conjugates in medicine.

Abstract: A method for assisting wallet providers in regulatory compliance for blockchain transactions includes: receiving, by a receiver of a processing server, a new blockchain transaction from a first computing device, the new blockchain including at least a destination address associated with a blockchain wallet as a recipient for the new blockchain transaction; generating, by a processor of the processing server, a reference identifier for the new blockchain transaction; identifying, by the processor of the processing server, a profile for the blockchain wallet based on the destination address; transmitting, by a transmitter of the processing server, the reference identifier to the first computing device; and transmitting, by the transmitter of the processing server, a notification message to a second computing device, the notification message including at least the reference identifier and data associated with the blockchain wallet.

Abstract: A valve system includes a housing that houses a fluid path having an inlet side and an outlet side, and a fluid purge port disposed at and in fluid communication with the outlet side of the fluid path. The housing includes: an inlet valve disposed in fluid communication with the fluid path at the inlet side and in operable communication with an inlet gear; an outlet valve disposed in fluid communication with the fluid path at the outlet side and in operable communication with an outlet gear; and a control gear disposed in operable communication with both the inlet gear and the outlet gear.

Abstract: The present disclosure relates to secure and verifiable storage and retrieval of data, in particular in the context of product tracking. According to one aspect there is provided a computer-implemented verifiable data storage method comprising: receiving a product serial number; receiving an account identifier; producing a non-invertible hash by operating on the product serial number and the account identifier; and causing the hash to be written to a secure distributed data store. According to another aspect there is provided a computer-implemented verification method comprising: receiving a product serial number; receiving an account identifier; producing a non-invertible hash by operating on the product serial number and the account identifier; searching a secure distributed data store for the hash; and depending on a result of the searching, providing confirmation or denial of the hash's presence in the secure distributed data store.

Abstract: Various exemplary methods and devices (10, 110, 210) for delivering liquid therapeutic agents in solid tumors are provided. In general, a delivery device configured to deliver a liquid therapeutic agent into a solid tumor or other soft tissue can be configured to compress tissue and seal any fluid gaps around the delivery device during the delivery of the liquid therapeutic agent. In an exemplary embodiment the delivery device includes three elongate tubular shafts (12, 14, 16, 112, 114, 116, 212, 214, 216) configured to move longitudinally relative to one another. The elongate tubular shafts are configured to cooperate with one another to deliver the liquid therapeutic agent through a passageway of the delivery device to the solid tumor or other soft tissue and seal any fluid gaps around the delivery device while the liquid therapeutic agent is delivered into the solid tumor or other soft tissue.

Abstract: Various exemplary steerable needles, methods of using steerable needles, and methods of manufacturing steerable needles are provided. In general, a needle configured to be advanced through soft tissue can be configured to be passively steered in a desired direction through the soft tissue. The needle can include a distal tip configured to facilitate the steering. The needle's distal tip can include a beveled or chamfered edge on one side thereof. The distal tip of the needle can be configured to bend relative to a remainder of the needle in a direction opposite to the side of the distal tip that includes the chamfered edge. The soft tissue can provide resistance to the distal tip being advanced therein such that the distal tip automatically bends in a direction away from the chamfered edge. The needle can also include a bendable portion that is proximal to the distal tip.

Abstract: In general, drug administration devices configured to communicate with networks and external devices are provided. In an exemplary embodiment, a drug administration device is configured to adjust an operational parameter of the drug administration device based on a data packet formed from drug administration data ancillary data received from networks and/or external devices. In another example embodiment, a drug administration device is configured to scan for and establish communications with at least one external device. In another example embodiment, a method includes assessing whether to update a control program on a drug administration device from a network or external device. In another example embodiment, a system includes a first drug administration device configured to communicate with a second drug administration device to optimize a drug treatment.

Abstract: A system can be configured to generate and analyze one or more candidate logistics maps based on a set of input parameters and a baseline map of a logistics facility. The system can identify modifications strategies, resource limits, regions of interest, mapping constraints through analysis of the input parameters and the baseline map. The generated candidate maps and the baseline map can be implemented in virtual environments that are configured to replicate one or more operations associated with the baseline map, such as item distribution, item retrieval, and reorganization operations. The virtual environment can further simulate the resource limits associated with the baseline map and compare performance indicators from simulation of the baseline map to performance indicators from simulation of the candidate maps to identify viable improvements over existing logistics solutions.

Abstract: An implant-delivery sleeve may comprise an enclosure having at least one opening and at least one vent conduit. The vent conduit may extend along a surface of the enclosure to assist in removing fluids (e.g., blood and air) from the tissue pocket to facilitate implantation of the implant.

Abstract: A valve system includes a housing that houses a fluid path having an inlet side and an outlet side, and a fluid purge port disposed at and in fluid communication with the outlet side of the fluid path. The housing includes: an inlet valve disposed in fluid communication with the fluid path at the inlet side and in operable communication with an inlet gear; an outlet valve disposed in fluid communication with the fluid path at the outlet side and in operable communication with an outlet gear; and a control gear disposed in operable communication with both the inlet gear and the outlet gear.

Abstract: An implant-delivery sleeve may comprise an enclosure having at least one opening and at least one vent conduit. The vent conduit may extend along a surface of the enclosure to assist in removing fluids (e.g., blood and air) from the tissue pocket to facilitate implantation of the implant.

Abstract: A respiratory treatment apparatus generates an indication of inspiration or expiration based on a measure of motor current of a flow generator. In an example, first and second current signals are derived from the measurement. The first derived current signal may be a long term measure or average of current and the second derived current signal may be a short term measure or average of current. A processor 120 determines an indication of inspiration or expiration as a function of the first and second derived current signals. The function of the first derived current signal and the second derived current signal may be a comparison of the derived current signals. The derived signals may be determined by filtering. The indication of inspiration or expiration may serve as a trigger or cycle control for changing treatment pressure in synchrony with patient respiration without measured signals from pressure, flow or speed sensors.

Abstract: A method for assisting wallet providers in regulatory compliance for blockchain transactions includes: receiving, by a receiver of a processing server, a new blockchain transaction from a first computing device, the new blockchain including at least a destination address associated with a blockchain wallet as a recipient for the new blockchain transaction; generating, by a processor of the processing server, a reference identifier for the new blockchain transaction; identifying, by the processor of the processing server, a profile for the blockchain wallet based on the destination address; transmitting, by a transmitter of the processing server, the reference identifier to the first computing device; and transmitting, by the transmitter of the processing server, a notification message to a second computing device, the notification message including at least the reference identifier and data associated with the blockchain wallet.

Abstract: A stator assembly has coils in a distributed winding configuration. A poly-phase switched reluctance motor assembly may include a stator assembly with multiple coils in a distributed winding configuration. The stator assembly may have a central bore into which a rotor assembly having multiple poles is received and configured to rotate. A method of controlling a switched reluctance motor may include at least three phases wherein during each conduction period a first phase is energized with negative direction current, a second phase is energized with positive current and there is at least one non-energized phase. During each commutation period either the first phase or second phase switches off to a non-energized state and one of the non-energized phases switches on to an energized state with the same direction current as the first or second phase that was switched off. The switched reluctance motor may include a distributed winding configuration.