Abstract: An inserter assembly (200) for deploying an intravesical device into a urinary bladder of a patient includes a placement catheter (210), a receiving funnel (220), and a stylet (230). The placement catheter defines a lumen extending from a proximal catheter end to an exit opening. The receiving funnel is secured to the placement catheter. The stylet is removably received through the receiving funnel within the lumen. The stylet includes a stylet body and a paddle (238). The stylet body is dimensioned to drive the intravesical device through the lumen and the exit opening into the bladder. The paddle is fixed to the stylet body about the proximal stylet end and is engageable with the receiving funnel. The paddle optionally includes a fitting (242) being lockably engageable with the receiving funnel to removably secure the stylet to the placement catheter.

Abstract: A method for assisting wallet providers in regulatory compliance for blockchain transactions includes: receiving, by a receiver of a processing server, a new blockchain transaction from a first computing device, the new blockchain including at least a destination address associated with a blockchain wallet as a recipient for the new blockchain transaction; generating, by a processor of the processing server, a reference identifier for the new blockchain transaction; identifying, by the processor of the processing server, a profile for the blockchain wallet based on the destination address; transmitting, by a transmitter of the processing server, the reference identifier to the first computing device; and transmitting, by the transmitter of the processing server, a notification message to a second computing device, the notification message including at least the reference identifier and data associated with the blockchain wallet.

Abstract: The present invention relates to antibody-drug conjugates comprising (i) an antibody or antigen-binding fragment thereof, (ii) a polymer comprising a particular repeat unit comprising an amino acid derivative, which is covalently bound to one or more biologically active moieties, such as small molecule drugs, optionally via a linker, and (iii) a polymer-antibody linker moiety which is covalently bound to both the polymer and the antibody or antigen-binding fragment thereof. Additionally, the present invention relates to pharmaceutical compositions comprising the antibody-drug conjugates and to use of the antibody-drug conjugates in medicine.

Abstract: In general, drug administration devices that communicate with surgical hubs and methods of using drug administration devices that communicate with surgical hubs are provided. In one aspect, a surgical system is provided that in one embodiment includes a drug administration device configured to administer a drug to a patient during performance of a surgical procedure. The drug administration device includes a first communications interface and a first processor configured to cause the first communications interface to transmit data regarding operation of the drug administration device during the performance of the surgical procedure. The surgical system also includes a surgical hub including a second processor and a second communications interface. The second communications interface is configured to receive the transmitted data from the first communications interface during the performance of the surgical procedure.

Abstract: A respiratory treatment apparatus generates an indication of inspiration or expiration based on a measure of motor current of a flow generator. In an example, first and second current signals are derived from the measurement. The first derived current signal may be a long term measure or average of current and the second derived current signal may be a short term measure or average of current. A processor 120 determines an indication of inspiration or expiration as a function of the first and second derived current signals. The function of the first derived current signal and the second derived current signal may be a comparison of the derived current signals. The derived signals may be determined by filtering. The indication of inspiration or expiration may serve as a trigger or cycle control for changing treatment pressure in synchrony with patient respiration without measured signals from pressure, flow or speed sensors.

Abstract: An aircraft includes an aircraft heat source; a propulsion system including an electric propulsion engine, the electric propulsion engine including an electric motor and a fan rotatable by the electric motor, the electric propulsion engine further defining a fan air flowpath; a thermal management system including a heat source exchanger in thermal communication with the aircraft heat source, a heat sink exchanger in thermal communication with the fan air flowpath of the electric propulsion engine, and a thermal distribution bus extending from the heat source exchanger to the heat sink exchanger; and a control system operably connected to the thermal management system for selectively thermally coupling the heat sink exchanger with the heat source exchanger.

Abstract: A stator assembly has coils in a distributed winding configuration. A poly-phase switched reluctance motor assembly may include a stator assembly with multiple coils in a distributed winding configuration. The stator assembly may have a central bore into which a rotor assembly having multiple poles is received and configured to rotate. A method of controlling a switched reluctance motor may include at least three phases wherein during each conduction period a first phase is energized with negative direction current, a second phase is energized with positive current and there is at least one non-energized phase. During each commutation period either the first phase or second phase switches off to a non-energized state and one of the non-energized phases switches on to an energized state with the same direction current as the first or second phase that was switched off. The switched reluctance motor may include a distributed winding configuration.

Abstract: An adjustable implant is disclosed herein. The adjustable implant may comprise a shell including membrane and a base and having a first diameter in a plane parallel to the base. A band may be disposed within the shell. The band may have a first end and a second end connected to a spool. The band may be in a round (e.g., elliptical) configuration having a second diameter in the plane that is less than the first diameter. By wrapping the band onto the spool, the diameter of the band may be decreased and the height of the implant may be increased. By unwrapping the band from the spool, the diameter of the band may be increased and the height of the implant may be decreased.

Abstract: A method for assisting wallet providers in regulatory compliance for blockchain transactions includes: receiving, by a receiver of a processing server, a new blockchain transaction from a first computing device, the new blockchain including at least a destination address associated with a blockchain wallet as a recipient for the new blockchain transaction; generating, by a processor of the processing server, a reference identifier for the new blockchain transaction; identifying, by the processor of the processing server, a profile for the blockchain wallet based on the destination address; transmitting, by a transmitter of the processing server, the reference identifier to the first computing device; and transmitting, by the transmitter of the processing server, a notification message to a second computing device, the notification message including at least the reference identifier and data associated with the blockchain wallet.

Abstract: A valve system includes a housing that houses a fluid path having an inlet side and an outlet side, and a fluid purge port disposed at and in fluid communication with the outlet side of the fluid path. The housing includes: an inlet valve disposed in fluid communication with the fluid path at the inlet side and in operable communication with an inlet gear; an outlet valve disposed in fluid communication with the fluid path at the outlet side and in operable communication with an outlet gear; and a control gear disposed in operable communication with both the inlet gear and the outlet gear.

Abstract: The present disclosure relates to secure and verifiable storage and retrieval of data, in particular in the context of product tracking. According to one aspect there is provided a computer-implemented verifiable data storage method comprising: receiving a product serial number; receiving an account identifier; producing a non-invertible hash by operating on the product serial number and the account identifier; and causing the hash to be written to a secure distributed data store. According to another aspect there is provided a computer-implemented verification method comprising: receiving a product serial number; receiving an account identifier; producing a non-invertible hash by operating on the product serial number and the account identifier; searching a secure distributed data store for the hash; and depending on a result of the searching, providing confirmation or denial of the hash's presence in the secure distributed data store.

Abstract: A system can be configured to generate and analyze one or more candidate logistics maps based on a set of input parameters and a baseline map of a logistics facility. The system can identify modifications strategies, resource limits, regions of interest, mapping constraints through analysis of the input parameters and the baseline map. The generated candidate maps and the baseline map can be implemented in virtual environments that are configured to replicate one or more operations associated with the baseline map, such as item distribution, item retrieval, and reorganization operations. The virtual environment can further simulate the resource limits associated with the baseline map and compare performance indicators from simulation of the baseline map to performance indicators from simulation of the candidate maps to identify viable improvements over existing logistics solutions.

Abstract: A valve system includes a housing that houses a fluid path having an inlet side and an outlet side, and a fluid purge port disposed at and in fluid communication with the outlet side of the fluid path. The housing includes: an inlet valve disposed in fluid communication with the fluid path at the inlet side and in operable communication with an inlet gear; an outlet valve disposed in fluid communication with the fluid path at the outlet side and in operable communication with an outlet gear; and a control gear disposed in operable communication with both the inlet gear and the outlet gear.

Abstract: An implant-delivery sleeve may comprise an enclosure having at least one opening and at least one vent conduit. The vent conduit may extend along a surface of the enclosure to assist in removing fluids (e.g., blood and air) from the tissue pocket to facilitate implantation of the implant.

Abstract: A method for assisting wallet providers in regulatory compliance for blockchain transactions includes: receiving, by a receiver of a processing server, a new blockchain transaction from a first computing device, the new blockchain including at least a destination address associated with a blockchain wallet as a recipient for the new blockchain transaction; generating, by a processor of the processing server, a reference identifier for the new blockchain transaction; identifying, by the processor of the processing server, a profile for the blockchain wallet based on the destination address; transmitting, by a transmitter of the processing server, the reference identifier to the first computing device; and transmitting, by the transmitter of the processing server, a notification message to a second computing device, the notification message including at least the reference identifier and data associated with the blockchain wallet.

Abstract: A stator assembly has coils in a distributed winding configuration. A poly-phase switched reluctance motor assembly may include a stator assembly with multiple coils in a distributed winding configuration. The stator assembly may have a central bore into which a rotor assembly having multiple poles is received and configured to rotate. A method of controlling a switched reluctance motor may include at least three phases wherein during each conduction period a first phase is energized with negative direction current, a second phase is energized with positive current and there is at least one non-energized phase. During each commutation period either the first phase or second phase switches off to a non-energized state and one of the non-energized phases switches on to an energized state with the same direction current as the first or second phase that was switched off. The switched reluctance motor may include a distributed winding configuration.

Abstract: A method of a control system controls an inductance motor in a device that may include an impeller using a pressure compensation control system. The control system may be implemented in a respiratory pressure therapy device. The control system may include a sensor configured to provide a pressure signal indicative of the pressure of a flow of fluid produced by the device. A measured pressure may be compared to a set pressure to determine a pressure error. A slip frequency may be adjusted as a function of the pressure error in an attempt to eliminate or minimise the pressure error.

Abstract: A utility power regulation system includes a power converter configured to regulate one or more of a voltage and a power factor at the primary side of a step-up transformer, or at a load electrically connected to a load feeder line, based on an estimated primary-side line voltage signal. The system includes a voltage estimation circuit configured to estimate the primary-side line voltage signal from one or more signals received from a secondary-side voltage sensor, regulator line current signal, and a primary-side load feeder-line current sensor.