Abstract: An implant-delivery sleeve may comprise an enclosure having at least one opening and at least one vent conduit. The vent conduit may extend along a surface of the enclosure to assist in removing fluids (e.g., blood and air) from the tissue pocket to facilitate implantation of the implant.

Abstract: A polynucleotide with a selection marker sequence under the control of a desirable HSVMin promoter leads to improved efficiency for biotechnology applications. The polynucleotide may, for example, be a transposon for use with Tc1/mariner systems. Through various embodiments of the present disclosure, one is able to efficiently and effectively introduce cargo regions from polynucleotides such as those carrying a glutamine synthetase gene into a host's DNA.

Abstract: A method includes receiving at least a portion of a shared operating conditions model from a remote statistics processor, receiving real-time sensor measurement data from sensors of the vehicle, determining a vehicle-specific operating conditions model based on the portion of the shared operating conditions model and the real-time sensor measurement data, and using the vehicle-specific operating conditions model to predict upcoming operating conditions for the vehicle. Another method includes receiving respective sensor measurement data from a plurality of vehicles, determining a shared operating conditions model based on the measurement data, and causing provision of at least a portion of the shared operating conditions model to a specific vehicle.

Abstract: An inserter assembly (200) for deploying an intravesical device into a urinary bladder of a patient includes a placement catheter (210), a receiving funnel (220), and a stylet (230). The placement catheter defines a lumen extending from a proximal catheter end to an exit opening. The receiving funnel is secured to the placement catheter. The stylet is removably received through the receiving funnel within the lumen. The stylet includes a stylet body and a paddle (238). The stylet body is dimensioned to drive the intravesical device through the lumen and the exit opening into the bladder. The paddle is fixed to the stylet body about the proximal stylet end and is engageable with the receiving funnel. The paddle optionally includes a fitting (242) being lockably engageable with the receiving funnel to removably secure the stylet to the placement catheter.

Abstract: The present invention relates to antibody-drug conjugates comprising (i) an antibody or antigen-binding fragment thereof, (ii) a polymer comprising a particular repeat unit comprising an amino acid derivative, which is covalently bound to one or more biologically active moieties, such as small molecule drugs, optionally via a linker, and (iii) a polymer-antibody linker moiety which is covalently bound to both the polymer and the antibody or antigen-binding fragment thereof. Additionally, the present invention relates to pharmaceutical compositions comprising the antibody-drug conjugates and to use of the antibody-drug conjugates in medicine.

Abstract: An adjustable implant is disclosed herein. The adjustable implant may comprise a shell including membrane and a base and having a first diameter in a plane parallel to the base. A band may be disposed within the shell. The band may have a first end and a second end connected to a spool. The band may be in a round (e.g., elliptical) configuration having a second diameter in the plane that is less than the first diameter. By wrapping the band onto the spool, the diameter of the band may be decreased and the height of the implant may be increased. By unwrapping the band from the spool, the diameter of the band may be increased and the height of the implant may be decreased.

Abstract: The present invention relates to antibody-drug conjugates comprising (i) an antibody or antigen-binding fragment thereof, (ii) a polymer comprising a particular repeat unit comprising an amino acid derivative, which is covalently bound to one or more biologically active moieties, such as small molecule drugs, optionally via a linker, and (iii) a polymer-antibody linker moiety which is covalently bound to both the polymer and the antibody or antigen-binding fragment thereof. Additionally, the present invention relates to pharmaceutical compositions comprising the antibody-drug conjugates and to use of the antibody-drug conjugates in medicine.

Abstract: A valve system includes a housing that houses a fluid path having an inlet side and an outlet side, and a fluid purge port disposed at and in fluid communication with the outlet side of the fluid path. The housing includes: an inlet valve disposed in fluid communication with the fluid path at the inlet side and in operable communication with an inlet gear; an outlet valve disposed in fluid communication with the fluid path at the outlet side and in operable communication with an outlet gear; and a control gear disposed in operable communication with both the inlet gear and the outlet gear.

Abstract: Various exemplary steerable needles, methods of using steerable needles, and methods of manufacturing steerable needles are provided. In general, a needle configured to be advanced through soft tissue can be configured to be passively steered in a desired direction through the soft tissue. The needle can include a distal tip configured to facilitate the steering. The needle's distal tip can include a beveled or chamfered edge on one side thereof. The distal tip of the needle can be configured to bend relative to a remainder of the needle in a direction opposite to the side of the distal tip that includes the chamfered edge. The soft tissue can provide resistance to the distal tip being advanced therein such that the distal tip automatically bends in a direction away from the chamfered edge. The needle can also include a bendable portion that is proximal to the distal tip.

Abstract: A system can be configured to generate and analyze one or more candidate logistics maps based on a set of input parameters and a baseline map of a logistics facility. The system can identify modifications strategies, resource limits, regions of interest, mapping constraints through analysis of the input parameters and the baseline map. The generated candidate maps and the baseline map can be implemented in virtual environments that are configured to replicate one or more operations associated with the baseline map, such as item distribution, item retrieval, and reorganization operations. The virtual environment can further simulate the resource limits associated with the baseline map and compare performance indicators from simulation of the baseline map to performance indicators from simulation of the candidate maps to identify viable improvements over existing logistics solutions.

Abstract: An implant-delivery sleeve may comprise an enclosure having at least one opening and at least one vent conduit. The vent conduit may extend along a surface of the enclosure to assist in removing fluids (e.g., blood and air) from the tissue pocket to facilitate implantation of the implant.

Abstract: A valve system includes a housing that houses a fluid path having an inlet side and an outlet side, and a fluid purge port disposed at and in fluid communication with the outlet side of the fluid path. The housing includes: an inlet valve disposed in fluid communication with the fluid path at the inlet side and in operable communication with an inlet gear; an outlet valve disposed in fluid communication with the fluid path at the outlet side and in operable communication with an outlet gear; and a control gear disposed in operable communication with both the inlet gear and the outlet gear.

Abstract: An implant-delivery sleeve may comprise an enclosure having at least one opening and at least one vent conduit. The vent conduit may extend along a surface of the enclosure to assist in removing fluids (e.g., blood and air) from the tissue pocket to facilitate implantation of the implant.

Abstract: In general, drug administration devices that communicate with surgical hubs and methods of using drug administration devices that communicate with surgical hubs are provided.

Abstract: An adjustable implant is disclosed herein. The adjustable implant may comprise a shell including membrane and a base and having a first diameter in a plane parallel to the base. A band may be disposed within the shell. The band may have a first end and a second end connected to a spool. The band may be in a round (e.g., elliptical) configuration having a second diameter in the plane that is less than the first diameter. By wrapping the band onto the spool, the diameter of the band may be decreased and the height of the implant may be increased. By unwrapping the band from the spool, the diameter of the band may be increased and the height of the implant may be decreased.

Abstract: An adjustable implant is disclosed herein. The adjustable implant may comprise a shell including membrane and a base and having a first diameter in a plane parallel to the base. A band may be disposed within the shell. The band may have a first end and a second end connected to a spool. The band may be in a round (e.g., elliptical) configuration having a second diameter in the plane that is less than the first diameter. By wrapping the band onto the spool, the diameter of the band may be decreased and the height of the implant may be increased. By unwrapping the band from the spool, the diameter of the band may be increased and the height of the implant may be decreased.

Abstract: Various embodiments of an adjustable implant are disclosed herein. The adjustable implant comprises a hydraulic mechanism disposed within the shell, which includes a first component and a second component that is moveable with respect to the first component, and a band with a first and second end disposed within the shell in a round (e.g., elliptical) configuration having a second diameter in the plane that is less than the first diameter. In some embodiments, the first end of the band may be connected to the first component and the second end of the band may be connected to the second component. In some embodiments, the mechanism may include a fluid and a pump that has a first actuator comprising a first chamber and a second actuator comprising a second chamber. Depressing the first actuator causes the first component to move in a first direction, which reduces the diameter of the band and increases the height of the implant.