Abstract: MiniVectors and compositions containing MiniVectors that target genes implicated in IPF selected from CDH11, STAT3, STAT6, FoxM1, MDM2, TGF?, SMAD, PDGFA, or TLR4 and/or increase intracellular levels of reduced glutathione, relaxin, and p53, are provided, along with uses in the treatment of idiopathic pulmonary fibrosis.

Abstract: MiniVectors and compositions containing MiniVectors that are ultrapure, and methods of making and using ultrapure MiniVectors for gene therapy uses, including long term repeated gene therapy uses.

Abstract: Described herein is coating starch composition comprising a starch and a plasticizer, as well as a paper coating composition comprising said coating starch composition, where the paper coating composition contains at least 2% starch, a dry solids content of at least 40%, and a viscosity of less than about 1200 cPs, as well as methods of using and making such compositions, such as, for example, in paper manufacturing processes.

Abstract: Apparatus (10) for restricting a flow of fluid through a bore (14) comprises a bore sealing member (12a) and an actuation assembly for moving the bore sealing member (12a) between first and second configurations. The actuation assembly is configured to isolate first and second end portions (46, 48) of the activation member (12a) from a bore fluid (50). The apparatus (10) provides for moving the bore sealing member (12a) between the first and second configurations without a bore fluid (50) pressure acting on an end portion (46, 48) of the activation member (12a).

Abstract: A method of making a paper-based product includes substantially continuously treating a papermaking furnish including from greater than 0% to 100% recycled fibers with a biocide, and forming the furnish into the paper-based product. The furnish has a microorganism level of greater than 5,000 colony forming units per gram, and substantially continuously treating the furnish with the biocide reduces the microorganism level so that the paper-based product has a microorganism level of less than 5,000 colony forming units per gram.

Abstract: Apparatus (10) for restricting a flow of fluid through a bore (14) comprises a bore sealing member (12a) and an actuation assembly for moving the bore sealing member (12a) between first and second configurations. The actuation assembly is configured to isolate first and second end portions (46, 48) of the activation member (12a) from a bore fluid (50). The apparatus (10) provides for moving the bore sealing member (12a) between the first and second configurations without a bore fluid (50) pressure acting on an end portion (46, 48) of the activation member (12a).

Abstract: A wireline hay pulley has a support with front and back plates extending therefrom. A sheave disposed between the plates can rotate on an axle. The front plate is affixed to the support, while the back plate is removably connected to the support. The front plate has a round opening in which an eccentric bushing on the axle can rotate. When the back plate is disconnected from the support, the back plate can turn the axle fixed in a slotted opening. An eccentric bushing on the axle rotates in an opening of the front plate, thereby shifting the sheave away from the support. With the back plate moved away and the sheave shifted downward, an operator can readily rig up a wireline in the sheave's slot.

Abstract: A stuffing box assembly for a wellhead intervention has a stuffing box and an adjustable sheave. The stuffing box has a body with a collar for connecting to a wellhead and with a passage for running wireline therethrough. A frame connected to the body has side plates and has a hub assembly with hubs rotatable about a first rotational axis. An axle interconnects the two hubs and supports them between the side plates. The sheave can rotate about the second rotational axis of the axel to run the wireline into and out of the stuffing box. The hub assembly can be rotated about its axis of rotation to adjust the location of the axle's axis of rotation. This can move the sheave away from a fixed guard, can change how the sheave lines up with the stuffing box, and can move the sheave away from the stuffing box.

Abstract: A stuffing box assembly for a wellhead intervention has a stuffing box and an adjustable sheave assembly. The stuffing box has a body with a collar for connecting to a wellhead and with a passage for running wireline therethrough. A frame connected to the body has first and second side plates. A hub assembly disposed on the frame has first and second hubs that are rotatable about a first axis of rotation on the side plates. An axle interconnects the two hubs and supports the axle between the side plates. The sheave can rotate about the second axis of rotation of the axel to run the wireline into and out of the stuffing box. The hub assembly can be rotated about its axis of rotation and can thereby adjust the location of the axle's axis of rotation.

Abstract: A wireline hay pulley has a support with front and back plates extending therefrom. A sheave disposed between the plates can rotate on an axle. The front plate is affixed to the support, while the back plate is removably connected to the support. The front plate has a round opening in which an eccentric bushing on the axle can rotate. When the back plate is disconnected from the support, the back plate can turn the axle fixed in a slotted opening. An eccentric bushing on the axle rotates in an opening of the front plate, thereby shifting the sheave away from the support. With the back plate moved away and the sheave shifted downward, an operator can readily rig up a wireline in the sheave's slot.

Abstract: Tubing reaming apparatus comprises a housing adapted to be mounted to tubing to be reamed. The housing provides mounting for a reamer shaft adapted to mount a cutter within the tubing. The housing also provides mounting for a drive arrangement. A gear arrangement is provided between the drive arrangement and the reamer shaft. The housing may comprise a clamping arrangement adapted to reduce residual bend and ovality of the tubing.