Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract: A vehicle sales matching system may include a vehicle sales lead data database, a vehicle sales information database, and a sales matching system embodied on a non-transitory computer-readable medium and communicatively connected to the vehicle sales lead data database and the vehicle sales information database. The vehicle sales lead data may include validated customer data and third-party customer data. The vehicle sales information may include sales data from vehicle dealers, data extract services, and sales data sources. The sales matching system may be configured for applying one or more matching rules for matching a vehicle sales lead from the vehicle sales lead database to a vehicle sale from the vehicle sales information database.

Abstract: Disclosed are compounds of Formula 1, N-oxides of the compounds and salts of the compounds and N-oxides: wherein R1, R2, R3, R4, R5, R6, Q1, Q2, J, Y1, and Y2 are as defined in the disclosure. Also disclosed are compositions containing the compounds, N-oxides and salts, and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of such a compound. N-oxide, salt or composition.

Abstract: Methods, systems, and devices for wireless communications are described. A user equipment (UE) may receive, via a first carrier associated with a first radio access technology, at least a first uplink grant from a base station. The UE may implement one or more backoff schemes. For example, the UE may transmit, using resources indicated by at least the first uplink grant, an uplink message based on a temperature of one or more components of the UE satisfying a threshold, the uplink message including a transport block (TB) indicating data, a buffer status report (BSR) associated with the data, one or more padding bytes different from the data, or any combination thereof. The UE may monitor for at least a second uplink grant from the base station during a first time period based on transmitting the uplink message.

Abstract: A method and system for Proactive Loss Prevention (PLP) System in venue and retail using wireless-based technology. Physical security measures are the first line of defense for protecting assets in any venue and retail spaces. These systems (e.g. Electronic Article Surveillance systems) are widely deployed in retail spaces. However, retail theft is still estimated at a multibillion dollar level on an annual basis in the US alone. This invention augments existing physical security systems to enable a proactive approach for suspect identification and subsequent presence alerting using a wireless local area network (WLAN) based system.

Abstract: Computer-implemented method and system for receiving and processing one or more moment-associating elements. For example, the computer-implemented method includes receiving the one or more moment-associating elements, transforming the one or more moment-associating elements into one or more pieces of moment-associating information, and transmitting at least one piece of the one or more pieces of moment-associating information.

Abstract: The invention relates to a method of treating a MEK-associated tumor by administering to a subject in need thereof a therapeutically effective amount of a solid form 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.

Abstract: The embodiments described herein generally relate to a stem assembly for coupling a susceptor to a process chamber. The stem assembly includes a pivot mechanism, a first flexible seal coupled to the pivot mechanism, a second flexible seal coupled to a plate on a first side of the plate, the plate having a second side coupled to the first flexible seal, a housing coupled to the second flexible seal, and a motion assembly adapted to move the housing in an X axis and a Y axis, and position the susceptor angularly relative to an X-Y plane of the process chamber.

Abstract: The present invention generally relates a composite material containing fibers and a resin matrix that comprises a PEEK-PEoEK copolymer having RPEEK and RPEoEK repeat units in a molar ratio RPEEK/RPEoEK ranging from 95/5 to 5/95 in contact with at least a part of the surface of such fibers. The present invention also relates to methods for making such composite materials, shaped articles made from such composite materials, and methods of making such articles.

Abstract: A ventricular assist device including a frame having a proximal end and an outer surface, and an anchor having a base and a brace coupled to the base. The base is attached to the proximal end of the frame. The device also includes a stator assembly coupled to the frame, a rotor assembly disposed between the stator assembly and the frame, and a power source operatively coupled to the stator assembly. The anchor is moveable between a collapsed configuration in which an inner surface of the brace contacts the outer surface of the frame, and an expanded configuration, in which the inner surface of the brace is offset from the outer surface of the frame and an outer surface of the brace engages a portion of the blood vessel to secure the frame within the blood vessel.

Abstract: In one embodiment, a susceptor for thermal processing is provided. The susceptor includes an outer rim surrounding and coupled to an inner dish, the outer rim having an inner edge and an outer edge. The susceptor further includes one or more structures for reducing a contacting surface area between a substrate and the susceptor when the substrate is supported by the susceptor. At least one of the one or more structures is coupled to the inner dish proximate the inner edge of the outer rim.

Abstract: Apparatus and methods for welding asset tracking with heartbeat monitoring are disclosed. In some examples, a welding asset tracking system may comprise an asset tracking network of tags, hubs, and/or gateways retained by welding assets within a welding area. The welding asset tracking system may generate heartbeat signals that certain welding assets may require for normal operation, so as to ensure the welding assets are used in appropriate welding contexts and/or welding areas. In some examples, information obtained from the asset tracking network may be used to determine whether one or more heartbeat signals should be discontinued.

Abstract: A system allows a user to store his personally identifiable information (PII) on a personal device. When a third party wants to access the user's PII (e.g., to update the PII or to retrieve the PII), a notification will be presented to the user on the personal device seeking consent to the access. The notification may inform the user as to what information is being requested and which entity is requesting the access. The requested access will be denied unless the user consents to the access. In this manner, the user is given control over the dissemination of his PII. Additionally, the system alters or adjusts the PII that is stored in third-party servers so that even if these servers are breached, the user's actual PII is not exposed.

Abstract: In an aspect, a user equipment (UE) may receive an uplink (UL) grant (e.g., dynamic UL grant, UL configured grant (CG)) from a network, but may decide to skip the UL grant altogether or not transmit any user plane data on the UL grant. In such instances, the UE may maintain or expedite expiration associated with one or more timers (e.g., discontinuous reception (DRX) and bandwidth part (BWP) inactivity timers, secondary cell (SCell) deactivation timer, etc.). The UE may also maintain or expedite expiration associated with one or more timers if it receives downlink (DL) transmission (e.g., DL semi-persistent scheduling (SPS)) from the network that includes no user plane data.

Abstract: When a third party wants to redeem a user's personally identifiable information (PII), the third party presents to the system a token representing the PII, which indicates a request for the PII. The system seeks consent from the user for sending the PII to the third party. If the user grants consent, then the system prepares the PII for the third party. In some embodiments, the third party can initiate a telephone call with a dispatch to receive the PII. In some embodiments, the third party can receive the PII directly from the system.

Abstract: A three-dimensional printing system includes a resin vessel containing resin, an imaging bar, a movement mechanism coupled to the imaging bar, and a controller. The imaging bar includes an arrangement of light emitting devices that selectively emit radiation from an exit surface of the imaging bar to define a build plane in the resin. The exit surface of the imaging bar is preferably less than 10 millimeters from the build plane. The controller is configured to scan the imaging bar along a scan axis and, concurrent with scanning, operate the imaging bar to selectively image a layer of resin at the build plane.

Abstract: A flexible multi-path RF adaptive tuning network switch architecture that counteracts impedance mismatch conditions arising from various combinations of coupled RF band filters, particularly in a Carrier Aggregation-based (CA) radio system. In one version, a digitally-controlled tunable matching network is coupled to a multi-path RF switch in order to provide adaptive impedance matching for various combinations of RF band filters. Optionally, some or all RF band filters include an associated digitally-controlled filter pre-match network to further improve impedance matching. In a second version, some or all RF band filters coupled to a multi-path RF switch include a digitally-controlled phase matching network to provide necessary per-band impedance matching. Optionally, a digitally-controlled tunable matching network may be included on the common port of the multi-path RF switch to provide additional impedance matching capability.

Abstract: The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.

Abstract: When personally identifiable information (PII) is to be stored or updated, a system first seeks consent from the user for the PII store or update. If the user grants consent, then the system stores the PII in the user's personal device or updates the PII stored in the user's personal device. The system then retrieves that PII and generates a token representing that PII. Even if the token were taken by a malicious user, it would not be possible for the malicious user to determine the user's actual PII from the token. In this manner, the security of the PII is improved over conventional systems.