Abstract: A method of forming a multipole magnet wherein two backing sheets of paper or film material are screen or stencil printed with an ink containing magnetic particles and a carrier material to provide respective complementary patterned areas thereon, the patterned areas of ink are cured or dried, the respective ink patterns are magnetized using a magnetic field perpendicular to a plane of the backing sheets, and the sheets are combined into a laminate wherein the patterned areas are located between the two sheets.

Abstract: A system and method for engine idle speed control delay operation of a vehicle accessory (26) while introducing a stored torque disturbance profile corresponding to that vehicle accessory into a feedforward engine control system so as to minimize variation of engine idle speed. Torque disturbances resulting from operation of an alternator (32), power steering pump (28), or air conditioning compressor and blower (30) are characterized and stored in the memory of an electronic control module (22). When a request for operation of an accessory is detected, the stored profile is fed into the control system prior to actual operation of the accessory so as to reduce or eliminate control system response time. Control logic (22) also provides a learning function by modifying the stored profiles to accommodate changes in engine and accessory operation.

Abstract: A method for identifying compounds capable of inducing immunosuppression by inhibiting the CD28 signal transduction pathway and T cell comprises exposing cultured T cells to one or more test compounds. The T cells are obtained from a T cell line which stably incorporates DNA sequence comprising in reading frame an enhancer region responsive to a CD28-regulated nuclear binding protein and a marker gene. The cells are cultured under conditions which result in activation of both the T cell receptor and the CD28 receptor, resulting in enhanced expression of the marker gene. Test compounds which inhibit expression of the marker gene are considered as candidates for immunosuppressive drugs.

Abstract: Quinolones with antihypertensive activity have the general formula I, ##STR1## wherein X is the residue of an optionally substituted benzene ring; R is lower alkyl; R.sub.3 is hydrogen or lower alkyl; R.sub.1 and R.sub.2, which may be the same or different, are hydrogen, lower alkyl, or, together with the nitrogen atom to which they are attached, form a 5 to 7 membered saturated heterocyclic ring optionally containing an additional hetero atom selected from nitrogen, oxygen and sulphur and optionally substituted by 1 or more lower alkyl groups; and the dotted line between positions 2 and 3 of the quinolone nucleus represents an optional bond. The compounds are useful as antihypertensive agents. They are also indicated for use in treating heart failure and ischaemic heart disease.

Abstract: Novel thienopyridones with antihypertensive activity have the formula I, ##STR1## wherein the ring A represents an optionally substituted thiophene ring; m is 0 or 1; n is 0, 1 or 2; R is lower alkyl and R.sub.1 is lower alkyl.The fused thieno-ring may carry one or two substituents.Formula I encompasses thieno[3,2-b]pyridones, thieno[3,4-b]pyridones and thieno[2,3-b]pyridones.Processes for preparing the novel thienopyridones and pharmaceutical compositions containing them are described. Pharmaceutically acceptable acid addition salts of the compounds of formula I are also described.The thienopyridones of formula I are antihypertensive agents and are also indicated for use in treating heart failure and ischaemic heart disease.

Abstract: Compositions which contain a quinolone compound of the general formula ##STR1## wherein n is 0, 1 or 2; R.sub.1 is lower alkyl optionally substituted by hydroxy or C.sub.1-4 alkoxycarbonyl; allyl; propynyl or phenyl- lower alkyl in which the phenyl ring is optionally substituted by 1 or 2 C.sub.1-4 alkoxy groups; R.sub.2 is C.sub.1-4 alkyl with the proviso that when n is 0, R.sub.2 is methyl; and R.sub.3, R.sub.4 and R.sub.5, which may be the same or different, are hydrogen, lower alkyl, lower alkoxy, lower alkanoyl, halo, trifluoromethyl or lower alkylthio show antihypertensive activity.Compounds of general formula ##STR2## in which n, R.sub.1 R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as described above are novel subject to the following provisos (a) when R.sub.3, R.sub.4 and R.sub.4 and R.sub.5 are hydrogen R.sub.2 is methyl and R.sub.1 is lower alkyl, R.sub.1 contains more than one carbon atom, and(b) when R.sub.3 and R.sub.4 are hydrogen, R.sub.5 is hydrogen or 7-methyl, and R.sub.1 is ethyl, R.sub.

Abstract: An apparatus for the direct measurement of total radiation dose from the difference in electrochemical potential between an unirradiated solution containing known concentrations of ceric and cerous ions and a gamma or electron irradiated solution initially containing the same known concentrations of ceric and cerous ions. The apparatus comprises a cell which is divided into two sections, which are separated by a porous frit. Unirradiated solution is placed in one section of the cell and irradiated solution is placed in the other section such that the potential difference across the two sections of the cell is converted into a total radiation dose reading of the irradiated solution.

Abstract: A logarithmic ratemeter has a plurality of bistable devices each having two inputs the first of which is connected to a common input line for receiving voltage pulses from a detector of atomic particles and the second of which is connected to a secondary pulse train. The secondary pulse trains for the bistable devices are all different but maintain a constant frequency relationship to one another. Each bistable device produces an output signal the level of which indicates whether the device is in its first or second state and means are provided for summing the average values of the outputs of the bistable devices so as to provide an output signal which is a logarithm of the pulse rate received at the common input.