Abstract: Compounds and compositions of matter are provided that are small molecule antimicrobials. The compounds are selected from JH-144, TH-04 or TH-08 or combinations thereof. Compositions of matter are provided which in an embodiment may comprise a carrier, and in further embodiments may comprise a pharmaceutically acceptable excipient, film, biofilm or edible film. Methods of use are provided in which the composition may be administered to a subject in need thereof, and in an embodiment where the subject has a bacterial infection. Other embodiments provide the composition may be contacted with surface to eliminate or reduce bacteria.

Abstract: Compounds and compositions of matter are provided that are small molecule antimicrobials. The compounds are selected from JH-144, TH-04 or TH-08 or combinations thereof. Compositions of matter are provided which in an embodiment may comprise a carrier, and in further embodiments may comprise a pharmaceutically acceptable excipient, film, biofilm or edible film. Methods of use are provided in which the composition may be administered to a subject in need thereof, and in an embodiment where the subject has a bacterial infection. Other embodiments provide the composition may be contacted with surface to eliminate or reduce bacteria.

Abstract: A goal securement device includes a ground engagement system, a ground securement system, a goal securement system, and a goal securement monitoring system. In an embodiment, the systems work cooperatively to secure a goal to the ground and monitor the status of such securement. Embodiments of each system and embodiments of various components, aspects, or features of each system are described.

Abstract: A goal securement device includes a ground engagement system, a ground securement system, a goal securement system, and a goal securement monitoring system. In an embodiment, the systems work cooperatively to secure a goal to the ground and monitor the status of such securement. Embodiments of each system and embodiments of various components, aspects, or features of each system are described.

Abstract: Described are arylnaphthalene lactone derivatives. Also disclosed herein are methods of use of the arylnaphthalene lactone derivatives as anticancer agents.

Abstract: A goal securement device includes a ground engagement system, a ground securement system, a goal securement system, and a goal securement monitoring system. In an embodiment, the systems work cooperatively to secure a goal to the ground and monitor the status of such securement. Embodiments of each system and embodiments of various components, aspects, or features of each system are described.

Abstract: A goal securement device includes a ground engagement system, a ground securement system, a goal securement system, and a goal securement monitoring system. In an embodiment, the systems work cooperatively to secure a goal to the ground and monitor the status of such securement. Embodiments of each system and embodiments of various components, aspects, or features of each system are described.

Abstract: A goal securement device includes a ground engagement system, a ground securement system, a goal securement system, and a goal securement monitoring system. In an embodiment, the systems work cooperatively to secure a goal to the ground and monitor the status of such securement. Embodiments of each system and embodiments of various components, aspects, or features of each system are described.

Abstract: A goal securement device includes a ground engagement system, a ground securement system, a goal securement system, and a goal securement monitoring system. In an embodiment, the systems work cooperatively to secure a goal to the ground and monitor the status of such securement. Embodiments of each system and embodiments of various components, aspects, or features of each system are described.

Abstract: A goal securement device includes a ground engagement system, a ground securement system, a goal securement system, and a goal securement monitoring system. In an embodiment, the systems work cooperatively to secure a goal to the ground and monitor the status of such securement. Embodiments of each system and embodiments of various components, aspects, or features of each system are described.

Abstract: In one aspect, the invention relates to substituted 2-(1H-indol-3-yl)ethanol analogs and substituted 3,3a,8,8a-tetrahydro-2H-furo[2,3-b]indole analogs, derivatives thereof, and related compounds, which are useful as inhibitors of IL-6 mediated activation of the Jak2/STAT3 pathway; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a IL6 dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: An indicator device for visually indicating a pressure of blood inside a blood vessel includes: a body, the body comprising a duct extending in the body and having a sealed proximal end; a distal end portion adapted to be positioned inside the blood vessel and including a liquid inlet opening in fluid communication with the duct; and a window including an at least semi-transparent section configured to enable visual observation of blood entering into the duct via the inlet opening when the inlet opening is located inside the blood vessel.

Abstract: An indicator device for visually indicating a pressure of blood inside a blood vessel includes: a body, the body comprising a duct extending in the body and having a sealed proximal end; a distal end portion adapted to be positioned inside the blood vessel and including a liquid inlet opening in fluid communication with the duct; and a window including an at least semi-transparent section configured to enable visual observation of blood entering into the duct via the inlet opening when the inlet opening is located inside the blood vessel.

Abstract: A closure with a snap type hinge cap including a first part adapted to interengage with the open neck of the container and a second part forming a cap. An integral hinge interconnects the first part and second part. Each of the parts includes a base wall and a peripheral skirt. A pair of hinged straps are attached to the skirts and extend from the skirts on opposite side of the integral hinge. The ends of the straps are straight and lie in substantially the same plane when the first part and second part are in fully open position. Each strap is stretched along its length during opening and closing of the first part and the second part. Each strap has a portion intermediate the ends which extends out of the plane when the first part and second part are in fully open position. Each intermediate portion of each strap is thinner than the ends of said strap. Each strap is untensioned when the first part and second part are in fully open position.