Patents by Inventor James G. Herman

James G. Herman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for identifying methylation patterns in a CpG-containing nucleic acid
    Patent number: 6200756
    Abstract: The present invention provides a method for detecting a methylated CpG-containing nucleic acid present in a specimen by contacting the specimen with an agent that modifies unmethlyated cytosine and amplifying the CpG-containing nucleic acid using CpG-specific oligonucleotide primers. The present invention provides an improved method of methylation detection by facilitating the rapid identification of DNA methylation patterns in a CpG-containing nucleic acid.
    Type: Grant
    Filed: July 28, 1998
    Date of Patent: March 13, 2001
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: James G. Herman, Stephen B. Baylin
  • Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
    Patent number: 6017704
    Abstract: The present invention provides a method for detecting a methylated CpG-containing nucleic acid present in a specimen by contacting the specimen with an agent that modifies unmethylated cytosine and amplifying the CpG-containing nucleic acid using CpG-specific oligonucleotide primers. The present invention provides an improved method of methylation detection by facilitating the rapid identification of DNA methylation patterns in a CpG-containing nucleic acid.
    Type: Grant
    Filed: April 11, 1997
    Date of Patent: January 25, 2000
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: James G. Herman, Stephen B. Baylin
  • Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
    Patent number: 5786146
    Abstract: The present invention provides a method of PCR, methylation specific PCR (MSP), for rapid identification of DNA methylation patterns in a CpG-containing nucleic acid. MSP uses agents to modify unmethylated cytosine in a nucleic acid of interest, and then uses the PCR reaction to amplify the CpG-containing nucleic acid in the specimen by means of CpG-specific oligonucleotide primers. The oligonecleotide primers distinguish between modified methylated and nonmethylated nucleic acid. Kits utilizing MSP for the detection of methylated CpG-containing nucleic acids are also provided.
    Type: Grant
    Filed: June 3, 1996
    Date of Patent: July 28, 1998
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: James G. Herman, Stephen B. Baylin
  • Stackable bar stool
    Patent number: D335034
    Type: Grant
    Filed: November 7, 1990
    Date of Patent: April 27, 1993
    Inventor: James G. Herman