Patents by Inventor James G. Moe
James G. Moe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120061622Abstract: The present invention provides means and methods for producing surface-activated semiconductor nanoparticles suitable for in vitro and in vivo applications that can fluoresce in response to light excitation. Semiconductor nanostructures can be produced by generating a porous layer in semiconductor substrate comprising a network of nanostructures. Prior or subsequent to cleavage from the substrate, the nanostructures can be activated by an activation means such as exposing their surfaces to a plasma, oxidation or ion implantation. In some embodiments, the surface activation renders the nanostructures more hydrophilic, thereby facilitating functionalization of the nanoparticles for either in vitro or in vivo use.Type: ApplicationFiled: August 23, 2011Publication date: March 15, 2012Applicant: SPIRE CORPORATIONInventors: Nader M. Kalkhoran, James G. Moe, Kurt J. Linden, Marisa Sambito
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Publication number: 20120029169Abstract: Tau protein has a causative role in Alzheimer's disease and multiple other neurodegenerative disorders exhibiting tau histopathology collectively termed tauopathies. The primary function of tau protein is to facilitate assembly and maintenance of microtubules in neuronal axons. In the disease process tau protein becomes modified, loses its affinity to microtubules and accumulates in the cell body where it forms aggregates. The large neurofibrillary tangles formed from tau protein assembled into filaments were thought to be the pathological structure of tau. However, more recent work indicates that smaller, soluble oligomeric forms of tau are best associated with neuron loss and memory impairment. Here, novel compositions of tau oligomers and novel mechanisms for tau oligomer nucleation, extension and termination are taught.Type: ApplicationFiled: August 21, 2009Publication date: February 2, 2012Applicant: OLIGOMERIX, INC.Inventors: James G. Moe, Eliot J. Davidowitz
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Publication number: 20110312059Abstract: Tau protein has a causative role in Alzheimer's disease and multiple other neurodegenerative disorders exhibiting tau histopathology collectively termed tauopathies. The primary function of tau protein is to facilitate assembly and maintenance of microtubules in neuronal axons. In the disease process tau protein becomes modified, loses its affinity to microtubules and accumulates in the cell body where it forms aggregates. The large neurofibrillary tangles formed from tau protein assembled into filaments were thought to be the pathological structure of tau. However, more recent work indicates that smaller, soluble oligomeric forms of tau are best associated with neuron loss and memory impairment. A novel and unexpected protease activity has been discovered to be associated with tau in oligomeric but not monomeric structures. Methods have been developed to form and purify tau protease and to assay its activity.Type: ApplicationFiled: August 20, 2009Publication date: December 22, 2011Applicant: Oligomerix Inc.Inventors: James G. Moe, Eliot J. Davidowitz
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Publication number: 20110237015Abstract: The present invention provides nanophotovoltaic devices having sizes in a range of about 50 nm to about 5 microns, and method of their fabrication. In some embodiments, the nanophotovoltaic device includes a semiconductor core, e.g., formed of silicon, sandwiched between two metallic layers, one of which forms a Schottky barrier junction with the semiconductor core and the other forms an ohmic contact therewith. In other embodiment, the nanophotovoltaic device includes a semiconductor core comprising a p-n junction that is sandwiched between two metallic layers forming ohmic contacts with the core.Type: ApplicationFiled: June 3, 2011Publication date: September 29, 2011Applicant: SPIRE CORPORATIONInventors: Steven J. Wojtczuk, James G. Moe, Roger G. Little
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Patent number: 8003551Abstract: The present invention provides means and methods for producing surface-activated semiconductor nanoparticles suitable for in vitro and in vivo applications that can fluoresce in response to light excitation. Semiconductor nanostructures can be produced by generating a porous layer in semiconductor substrate comprising a network of nanostructures. Prior or subsequent to cleavage from the substrate, the nanostructures can be activated by an activation means such as exposing their surfaces to a plasma, oxidation or ion implantation. In some embodiments, the surface activation renders the nanostructures more hydrophilic, thereby facilitating functionalization of the nanoparticles for either in vitro or in vivo use.Type: GrantFiled: April 27, 2009Date of Patent: August 23, 2011Assignee: Spire CorporationInventors: Nader Montazernezam Kalkhoran, James G. Moe, Kurt J. Linden, Marisa Sambito
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Patent number: 7955965Abstract: The present invention provides nanophotovoltaic devices having sizes in a range of about 50 nm to about 5 microns, and method of their fabrication. In some embodiments, the nanophotovoltaic device includes a semiconductor core, e.g., formed of silicon, sandwiched between two metallic layers, one of which forms a Schottky barrier junction with the semiconductor core and the other forms an ohmic contact therewith. In other embodiment, the nanophotovoltaic device includes a semiconductor core comprising a p-n junction that is sandwiched between two metallic layers forming ohmic contacts with the core.Type: GrantFiled: August 6, 2010Date of Patent: June 7, 2011Assignee: Spire CorporationInventors: Steven J. Wojtczuk, James G. Moe, Roger G. Little
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Publication number: 20110027817Abstract: This invention is directed to methods for determining if a test compound can ameliorate tau protein induced reduction of long term potentiation in a neural structure. The invention is also directed to methods for determining if a test compound can re-establish or rescue synaptic function in a neural structure following damage by tau proteins. Also encompassed by disclosures in this invention are methods to determine if a test compound can increase synaptic function in a neural structure contacted with tau proteins and methods for determining if a test compound is capable of treating Alzheimer's disease or other tauopathies in a subject.Type: ApplicationFiled: March 8, 2010Publication date: February 3, 2011Inventors: Ottavio Arancio, Daniela Puzzo, James G. Moe
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Publication number: 20100297803Abstract: The present invention provides nanophotovoltaic devices having sizes in a range of about 50 nm to about 5microns, and method of their fabrication. In some embodiments, the nanophotovoltaic device includes a semiconductor core, e.g., formed of silicon, sandwiched between two metallic layers, one of which forms a Schottky barrier junction with the semiconductor core and the other forms an ohmic contact therewith. In other embodiment, the nanophotovoltaic device includes a semiconductor core comprising a p-n junction that is sandwiched between two metallic layers forming ohmic contacts with the core.Type: ApplicationFiled: August 6, 2010Publication date: November 25, 2010Applicant: SPIRE CORPORATIONInventors: Steven J. Wojtczuk, James G. Moe, Roger G. Little
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Patent number: 7772612Abstract: The present invention provides nanophotovoltaic devices having sizes in a range of about 50 nm to about 5 microns, and method of their fabrication. In some embodiments, the nanophotovoltaic device includes a semiconductor core, e.g., formed of silicon, sandwiched between two metallic layers, one of which forms a Schottky barrier junction with the semiconductor core and the other forms an ohmic contact therewith. In other embodiment, the nanophotovoltaic device includes a semiconductor core comprising a p-n junction that is sandwiched between two metallic layers forming ohmic contacts with the core.Type: GrantFiled: February 19, 2009Date of Patent: August 10, 2010Assignee: Spire CorporationInventors: Steven J. Wojtczuk, James G. Moe, Roger G. Little
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Publication number: 20090224216Abstract: The present invention provides means and methods for producing surface-activated semiconductor nanoparticles suitable for in vitro and in vivo applications that can fluoresce in response to light excitation. Semiconductor nanostructures can be produced by generating a porous layer in semiconductor substrate comprising a network of nanostructures. Prior or subsequent to cleavage from the substrate, the nanostructures can be activated by an activation means such as exposing their surfaces to a plasma, oxidation or ion implantation. In some embodiments, the surface activation renders the nanostructures more hydrophilic, thereby facilitating functionalization of the nanoparticles for either in vitro or in vivo use.Type: ApplicationFiled: April 27, 2009Publication date: September 10, 2009Applicant: SPIRE CORPORATIONInventors: Nader M. Kalkhoran, James G. Moe, Kurt J. Linden, Marisa Sambito
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Publication number: 20090165852Abstract: The present invention provides nanophotovoltaic devices having sizes in a range of about 50 nm to about 5 microns, and method of their fabrication. In some embodiments, the nanophotovoltaic device includes a semiconductor core, e.g., formed of silicon, sandwiched between two metallic layers, one of which forms a Schottky barrier junction with the semiconductor core and the other forms an ohmic contact therewith. In other embodiment, the nanophotovoltaic device includes a semiconductor core comprising a p-n junction that is sandwiched between two metallic layers forming ohmic contacts with the core.Type: ApplicationFiled: February 19, 2009Publication date: July 2, 2009Applicant: SPIRE CORPORATIONInventors: Steven J. Wojtczuk, James G. Moe, Roger G. Little
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Patent number: 7524776Abstract: Means and methods for producing surface-activated semiconductor nanoparticles suitable for in vitro and in vivo applications that can fluoresce in response to light excitation. Semiconductor nanostructures can be produced by generating a porous layer in semiconductor substrate comprising a network of nanostructures. Prior or subsequent to cleavage from the substrate, the nanostructures can be activated by an activation means such as exposing their surfaces to a plasma, oxidation or ion implantation. In some embodiments, the surface activation renders the nanostructures more hydrophilic, thereby facilitating functionalization of the nanoparticles for either in vitro or in vivo use.Type: GrantFiled: November 30, 2004Date of Patent: April 28, 2009Assignee: Spire CorporationInventors: Nader M. Kalkhoran, James G. Moe, Kurt J. Linden, Marisa Sambito
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Patent number: 7514725Abstract: The present invention provides nanophotovoltaic devices having sizes in a range of about 50 nm to about 5 microns, and method of their fabrication. In some embodiments, the nanophotovoltaic device includes a semiconductor core, e.g., formed of silicon, sandwiched between two metallic layers, one of which forms a Schottky barrier junction with the semiconductor core and the other forms an ohmic contact therewith. In other embodiment, the nanophotovoltaic device includes a semiconductor core comprising a p-n junction that is sandwiched between two metallic layers forming ohmic contacts with the core.Type: GrantFiled: November 30, 2004Date of Patent: April 7, 2009Assignee: Spire CorporationInventors: Steven J. Wojtczuk, James G. Moe, Roger G. Little
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Publication number: 20080240985Abstract: The present invention relates to the detection of specific nucleic acid sequences, either by a process of amplification of specific nucleic acid sequences or not. More particularly the invention provides for improved compositions and methods for reducing the chance for contamination from manipulation of reagents, internal controls for amplification, and the use of automated apparatus for the automated detection of one, or more than one amplified nucleic acid sequences.Type: ApplicationFiled: July 19, 2007Publication date: October 2, 2008Inventors: Luigi Catanzariti, Bryan W. Kluttz, Marcela Vera-Garcia, J. Lawrence Burg, James G. Moe, Geoff A. McKinley
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Publication number: 20080220449Abstract: Methods, compositions and systems are provided for diagnosing, stratifying, or monitoring the progression or regression of Alzheimer's disease (AD), the methods, compositions and systems comprise detecting in a sample a level of at least one AD biomarker, the AD biomarker comprising at least phosphorylated tau pT217, soluble tau oligomer, tau-amyloid-beta 1-42 complex, a fragment thereof or a combination thereof and comparing the level from the sample to a reference level of phosphorylated tau pT217, soluble tau oligomer, and/or tau-amyloid-beta 1-42 complex to diagnose or stratify or monitor the progression or regression of AD. In various embodiments, diagnostic assay and screening kits are provided. In various embodiments, the assay and kits provided can monitor the therapeutic effect of a drug and/or AD treatment.Type: ApplicationFiled: February 8, 2008Publication date: September 11, 2008Applicant: OLIGOMERIX, INC.Inventors: Sara Vasan, Eliot J. Davidowitz, James G. Moe
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Patent number: 7309588Abstract: The present invention relates to the detection of specific nucleic acid sequences after an amplification process, or directly without amplification. In particular, the invention provides for the automation of the amplification and detection process, the amplification and detection of one or more specific nucleic acid sequences, the use of internal controls, reduced potential for contamination caused by the manual manipulation of reagents, and improved reagent compositions to better control assay performance and provide for further protection against contamination.Type: GrantFiled: July 9, 2001Date of Patent: December 18, 2007Assignee: bioMerieux, Inc.Inventors: J. Lawrence Burg, Bryan W. Kluttz, Luigi Catanzariti, Marcela Vera-Garcia, James G. Moe, Geoff A. McKinley
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Patent number: 7262008Abstract: The present invention relates to the detection of specific nucleic acid sequences, either by a process of amplification of specific nucleic acid sequences or not. More particularly the invention provides for improved compositions and methods for reducing the chance for contamination from manipulation of reagents, internal controls for amplification, and the use of automated apparatus for the automated detection of one, or more than one amplified nucleic acid sequences.Type: GrantFiled: August 8, 2002Date of Patent: August 28, 2007Assignee: bioMerieux, Inc.Inventors: Luigi Catanzariti, Bryan W. Kluttz, Marcela Vera-Garcia, J. Lawrence Burg, James G. Moe, Geoff A. McKinley
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Publication number: 20040248087Abstract: The present invention relates to the detection of specific nucleic acid sequences after an amplification process, or directly without amplification. In particular, the invention provides for the automation of the amplification and detection process, the amplification and detection of one or more specific nucleic acid sequences, the use of internal controls, reduced potential for contamination caused by the manual manipulation of reagents, and improved reagent compositions to better control assay performance and provide for further protection against contamination.Type: ApplicationFiled: July 9, 2001Publication date: December 9, 2004Inventors: J. Lawrence Burg, Bryan W. Kluttz, Luigi Catanzariti, Marcela Vera-Garcia, James G. Moe, Geoff A. McKinley
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Patent number: 6586234Abstract: The present invention relates to the detection of specific nucleic acid sequences after an amplification process, or directly without amplification. In particular, the invention provides for the automation of the amplification and detection process, the amplification and detection of one or more specific nucleic acid sequences, the use of internal controls, reduced potential for contamination caused by the manual manipulation of reagents, and improved reagent compositions to better control assay performance and provide for further protection against contamination.Type: GrantFiled: February 5, 1999Date of Patent: July 1, 2003Assignee: bioMerieux Vitek, Inc.Inventors: J. Lawrence Burg, Luigi Catanzariti, Marcela Vera-Garcia, James G. Moe
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Patent number: 6558901Abstract: The present invention relates to the detection of specific nucleic acid sequences, either by a process of amplification of specific nucleic acid sequences or not. More particularly the invention provides for improved compositions and methods for reducing the chance for contamination from manipulation of reagents, internal controls for amplification, and the use of automated apparatus for the automated detection of one, or more than one amplified nucleic acid sequences.Type: GrantFiled: April 24, 1998Date of Patent: May 6, 2003Assignee: bioMerieux VitekInventors: Luigi Catanzariti, Bryan W. Kluttz, Marcela Vera-Garcia, J. Lawrence Burg, James G. Moe, Geoff A. McKinley