Abstract: An oral appliance for treatment of medical conditions, such as obstructive sleep apnea and snoring, and/or for improving athletic performance, comprises a maxillary and a mandibular baseplate component each configured to conform to at least some of the teeth of the user; at least one pair of straps adjustably coupling the baseplate components, wherein the strap defines the relative horizontal positioning of the baseplate components; at least one pair of shim holding brackets coupled to one baseplate component; and a plurality of shims, wherein each shim is replaceably received in the shim holding bracket and configured to abut against the other baseplate component, wherein the shim when received within the shim holding bracket defines the relative vertical positioning of the baseplate components, and wherein the shims are provided in varying heights to allow for varying the vertical positioning of the oral appliance for a specific user.

Abstract: The present invention relates to L-aspartyl-3-(bicycloalkyl)-L-alanine alkyl esters having high sweetness intensity, of the formula: ##STR1## wherein R.sup.1 is a substituted or an unsubstituted bicycloalkyl ring, said ring having 7 to 8 carbon atoms, the 2-position ring carbon atom is bound to the alamine moiety, the two carbon atoms of the ring that are vicinal to the 2-position carbon are each substituted by a hydrogen or lower alkyl, the total number of alkyl groups bound to the vicinal carbons is less than three, and R.sup.2 is methyl. The "2R" configuration enantiomers of the R.sup.1 group are especially preferred. In preferred embodiments of the invention, R.sup.1 is a bornyl, camphanyl, norbornyl, 1-methylnorbornyl, 3-methylnorbornyl, 7,7-dimethylnorbornyl, bicyclo [2.2.2] octyl, or pinanyl ring. The compounds of the invention, or edible salts thereof, can be used for sweetening edible products such as foods and beverages.