Patents by Inventor James George Metz
James George Metz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220170037Abstract: The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).Type: ApplicationFiled: February 11, 2022Publication date: June 2, 2022Inventors: Terence A. WALSH, Daniel GACHOTTE, Ann Owens MERLO, Paul G. ROESSLER, James George METZ, Scott BEVAN, Jerry M. KUNER
-
Patent number: 10968437Abstract: Factors For the Production and Accumulation of Polyunsaturated Fatty Acids (PUFAs) Derived from PUFA Synthases Abstract Disclosed are novel enhancing factor proteins of the PUFA synthase systems, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified microorganisms comprising the same, and methods of making and using the same. Also disclosed are genetically modified microorganisms that have been genetically modified to express a PUFA synthase system for the production of PUFAs, wherein the microorganisms have been modified to express the novel enhancing factor proteins of the PUFA synthase system.Type: GrantFiled: August 21, 2018Date of Patent: April 6, 2021Assignee: DSM IP Assets B.V.Inventors: James George Metz, Jerry M. Kuner, David Glen McCaskill, Mendy Louise Foster
-
Patent number: 10087430Abstract: Disclosed are novel enhancing factor proteins of the PUFA synthase systems, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified microorganisms comprising the same, and methods of making and using the same. Also disclosed are genetically modified microorganisms that have been genetically modified to express a PUFA synthase system for the production of PUFAs, wherein the microorganisms have been modified to express the novel enhancing factor proteins of the PUFA synthase system.Type: GrantFiled: January 28, 2015Date of Patent: October 2, 2018Assignee: DSM IP Assets B.V.Inventors: James George Metz, Jerry M. Kuner, David Glen McCaskill, Mendy Louise Foster
-
Publication number: 20160348083Abstract: Factors For the Production and Accumulation of Polyunsaturated Fatty Acids (PUFAs) Derived from PUFA Synthases Abstract Disclosed are novel enhancing factor proteins of the PUFA synthase systems, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified microorganisms comprising the same, and methods of making and using the same. Also disclosed are genetically modified microorganisms that have been genetically modified to express a PUFA synthase system for the production of PUFAs, wherein the microorganisms have been modified to express the novel enhancing factor proteins of the PUFA synthase system.Type: ApplicationFiled: January 28, 2015Publication date: December 1, 2016Inventors: James George METZ, Jerry M. KUNER, David Glen MCCASKILL, Mendy Louise FOSTER
-
Patent number: 8829274Abstract: The present invention relates to compositions and methods for preparing poly-unsaturated long chain fatty acids in plants, plant parts and plant cells, such as leaves, roots, fruits and seeds. Nucleic acid sequences and constructs encoding PKS-like genes required for the poly-unsaturated long chain fatty acid production, including the genes responsible for eicosapentenoic acid production of Shewanella putrefaciens and novel genes associated with the production of docosahexenoic acid in Vibrio marinus are used to generate transgenic plants, plant parts and cells which contain and express one or more transgenes encoding one or more of the PKS-like genes associated with such long chain polyunsaturated fatty acid production. Expression of the PKS-like genes in the plant system permits the large scale production of poly-unsaturated long chain fatty acids such as eicosapentenoic acid and docosahexenoic acid for modification of the fatty acid profile of plants, plant parts and tissues.Type: GrantFiled: February 13, 2007Date of Patent: September 9, 2014Assignee: DSM IP Assets B.V.Inventors: Daniel Facciotti, James George Metz, Michael Lassner
-
Publication number: 20090098622Abstract: The present invention relates to compositions and methods for preparing poly-unsaturated long chain fatty acids in plants, plant parts and plant cells, such as leaves, roots, fruits and seeds. Nucleic acid sequences and constructs encoding PKS-like genes required for the poly-unsaturated long chain fatty acid production, including the genes responsible for eicosapentenoic acid production of Shewanella putrefaciens and novel genes associated with the production of docosahexenoic acid in Vibrio marinus are used to generate transgenic plants, plant parts and cells which contain and express one or more transgenes encoding one or more of the PKS-like genes associated with such long chain polyunsaturated fatty acid production. Expression of the PKS-like genes in the plant system permits the large scale production of poly-unsaturated long chain fatty acids such as eicosapentenoic acid and docosahexenoic acid for modification of the fatty acid profile of plants, plant parts and tissues.Type: ApplicationFiled: February 13, 2007Publication date: April 16, 2009Applicant: MARTEK BIOSCIENCES CORPORATIONInventors: Daniel Facciotti, James George Metz, Michael Lassner
-
Patent number: 7214853Abstract: The present invention relates to compositions and methods for preparing poly-unsaturated long chain fatty acids in plants, plant parts and plant cells, such as leaves, roots, fruits and seeds. Nucleic acid sequences and constructs encoding PKS-like genes required for the poly-unsaturated long chain fatty acid production, including the genes responsible for eicosapentenoic acid production of Shewanella putrefaciens and novel genes associated with the production of docosahexenoic acid in Vibrio marinus are used to generate transgenic plants, plant parts and cells which contain and express one or more transgenes encoding one or more of the PKS-like genes associated with such long chain polyunsaturated fatty acid production. Expression of the PKS-like genes in the plant system permits the large scale production of poly-unsaturated long chain fatty acids such as eicosapentenoic acid and docosahexenoic acid for modification of the fatty acid profile of plants, plant parts and tissues.Type: GrantFiled: December 27, 2002Date of Patent: May 8, 2007Assignee: Martek Biosciences CorporationInventors: Daniel Facciotti, James George Metz, Michael Lassner
-
Patent number: 6828475Abstract: By this invention, a plant &bgr;-ketoacyl-CoA synthase condensing enzyme is provided free from intact cells of said plant and capable of catalyzing the production of very long chain fatty acid molecules. Also contemplated are constructs comprising the nucleic acid sequence and a heterologous DNA sequence not naturally associated with the condensing enzyme encoding sequences, and which provide for at least transcription of a plant condensing enzyme encoding sequence in a host cell. In this fashion very long chain fatty acid molecules may be produced in a plant cell. Included are methods of modifying the composition of very long chain fatty acid molecules in a plant cell.Type: GrantFiled: May 30, 1996Date of Patent: December 7, 2004Assignee: Calgene LLCInventors: James George Metz, Kathryn Dennis Lardizabal, Michael W. Lassner
-
Publication number: 20030228668Abstract: By this invention, nucleic acid sequences encoding for fatty acyl-CoA:fatty alcohol acyltransferase (wax synthase) are provided, wherein said wax synthase is active in the formation of a wax ester from fatty alcohol and fatty acyl-CoA substrates. Of special interest is are nucleic acid sequences obtainable from a jojoba embryo wax synthase having an apparent molecular mass of approximately 33 kD. Also considered are amino acid and nucleic acid sequences obtainable from wax synthase proteins and the use of such sequences to provide transgenic host cells capable of producing wax esters.Type: ApplicationFiled: April 18, 2003Publication date: December 11, 2003Inventors: Kathryn Dennis Lardizabal, James George Metz, Michael W. Lassner
-
Patent number: 6596538Abstract: By this invention, nucleic acid sequences encoding for fatty acyl-CoA: fatty alcohol acyltransferase (wax synthase) are provided, wherein said wax synthase is active in the formation of a wax ester from fatty alcohol and fatty acyl-CoA substrates. Of special interest is are nucleic acid sequences obtainable from a jojoba embryo wax synthase having an apparent molecular mass of approximately 33 kD. Also considered are amino acid and nucleic acid sequences obtainable from wax synthase proteins and the use of such sequences to provide transgenic host cells capable of producing wax esters.Type: GrantFiled: June 5, 1998Date of Patent: July 22, 2003Assignee: Calgene LLCInventors: Kathryn Dennis Lardizabal, James George Metz, Michael W. Lassner
-
Publication number: 20030101486Abstract: The present invention relates to compositions and methods for preparing poly-unsaturated long chain fatty acids in plants, plant parts and plant cells, such as leaves, roots, fruits and seeds. Nucleic acid sequences and constructs encoding PKS-like genes required for the poly-unsaturated long chain fatty acid production, including the genes responsible for eicosapentenoic acid production of Shewanella putrefaciens and novel genes associated with the production of docosahexenoic acid in Vibrio marinus are used to generate transgenic plants, plant parts and cells which contain and express one or more transgenes encoding one or more of the PKS-like genes associated with such long chain polyunsaturated fatty acid production. Expression of the PKS-like genes in the plant system permits the large scale production of poly-unsaturated long chain fatty acids such as eicosapentenoic acid and docosahexenoic acid for modification of the fatty acid profile of plants, plant parts and tissues.Type: ApplicationFiled: December 27, 2002Publication date: May 29, 2003Applicant: Martek Biosciences Boulder CorporationInventors: Daniel Facciotti, James George Metz, Michael Lassner
-
Patent number: 6566583Abstract: The present invention relates to compositions and methods for preparing poly-unsaturated long chain fatty acids in plants, plant parts and plant cells, such as leaves, roots, fruits and seeds. Nucleic acid sequences and constructs encoding PKS-like genes required for the poly-unsaturated long chain fatty acid production, including the genes responsible for eicosapentenoic acid production of Shewanella putrefaciens and novel genes associated with the production of docosahexenoic acid in Vibrio marinus are used to generate transgenic plants, plant parts and cells which contain and express one or more transgenes encoding one or more of the PKS-like genes associated with such long chain polyunsaturated fatty acid production. Expression of the PKS-like genes in the plant system permits the large scale production of poly-unsaturated long chain fatty acids such as eicosapentenoic acid and docosahexenoic acid for modification of the fatty acid profile of plants, plant parts and tissues.Type: GrantFiled: January 14, 1999Date of Patent: May 20, 2003Inventors: Daniel Facciotti, James George Metz, Michael Lassner
-
Patent number: 6492509Abstract: By this invention, nucleic acid sequences encoding for fatty acyl-CoA: fatty alcohol acyltransferase (wax synthase) are provided, wherein wax synthase is active in the formation of a wax ester from fatty alcohol and fatty acyl-CoA substrates. Of special interest is are nucleic acid sequences obtainable from a jojoba embryo wax synthase having an apparent molecular mass of approximately 33 kD. Also considered are amino acid and nucleic acid sequences obtainable from wax synthase proteins and the use of such sequences to provide transgenic host cells capable of producing wax esters.Type: GrantFiled: December 4, 1998Date of Patent: December 10, 2002Assignee: Calgene LLCInventors: Kathryn Dennis Lardizabal, James George Metz, Michael W. Lassner
-
Production of polyunsaturated fatty acids by expression of polyketide-like synthesis genes in plants
Patent number: 6140486Abstract: The present invention relates to compositions and methods for preparing poly-unsaturated long chain fatty acids in plants, plant parts and plant cells, such as leaves, roots, fruits and seeds. Nucleic acid sequences and constructs encoding PKS-like genes required for the poly-unsaturated long chain fatty acid production, including the genes responsible for eicosapentenoic acid production of Shewanella putrefaciens and novel genes associated with the production of docosahexenoic acid in Vibrio marinus are used to generate transgenic plants, plant parts and cells which contain and express one or more transgenes encoding one or more of the PKS-like genes associated with such long chain polyunsaturated fatty acid production. Expression of the PKS-like genes in the plant system permits the large scale production of poly-unsaturated long chain fatty acids such as eicosapentenoic acid and docosahexenoic acid for modification of the fatty acid profile of plants, plant parts and tissues.Type: GrantFiled: June 4, 1998Date of Patent: October 31, 2000Assignee: Calgene LLCInventors: Daniel Facciotti, James George Metz, Michael Lassner -
Patent number: 5723747Abstract: The invention provides a method of producing a wax ester in a plant cell whereby a plant cell having a fatty acyl reductase expressed from a sequence heterologous to said plant is grown in the absence of a wax synthase expressed from a sequence which is heterologous to the plant. The invention also provides plant cells containing wax ester.Type: GrantFiled: June 1, 1994Date of Patent: March 3, 1998Assignee: Calgene, Inc.Inventors: Michael Lassner, James George Metz
-
Patent number: 5679881Abstract: By this invention, a plant cytoplasmic synthase protein is provided which is selected from the group consisting of a .beta.-ketoacyl-CoA synthase and a wax synthase, and is also free from intact cells of said plant and capable of catalyzing the production of very long chain fatty acid molecules. Also contemplated are constructs comprising the nucleic acid sequence and a heterologous DNA sequence not naturally associated with the plant cytoplasmic protein encoding sequences, and which provide for at least transcription of a plant cytoplasmic protein encoding sequence in a host cell. In this fashion very long chain fatty acid molecules may be produced in a host cell. Included are methods of modifying the composition of very long chain fatty acid molecules in a plant cell.Type: GrantFiled: June 23, 1994Date of Patent: October 21, 1997Assignee: Calgene, Inc.Inventors: James George Metz, Kathryn Dennis Lardizabal, Michael Lassner