Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a SOD1 gene, as well as methods of inhibiting expression of a SOD1 gene and methods of treating subjects having a SOD1-associated neurodegenerative disease or disorder, e.g., Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), and Down's syndrome (DS), using such dsRNAi agents and compositions.

Abstract: Securement arrangements for use in securing a patient interface to the skin of a patient include a substrate material having a first surface and an adhesive material disposed on the first surface. The locations of the adhesive material are varied so as to minimize repetitious adherence of the adhesive material to the patient during repeated applications.

Abstract: A macerator includes a housing that defines a chamber, an inlet and an outlet, the inlet to receive a flow of slurry; two or more elongate concentric bodies located within the chamber defining a gap between the surface of the outer body and the inner surface of the housing, at least one of the bodies rotatable about an axis, and each body comprising a plurality of apertures defining a flow path through each body; a baffle(s) that extend substantially the width of the gap to define a first portion containing the inlet, and a second portion containing the outlet, baffle(s) substantially inhibiting passage of slurry between the two portions via the gap such that the slurry is directed through the body apertures; a motor to drive the rotating body(ies); one or more injectors that inject liquid into the gap, at least one injector located in the first portion.

Abstract: A tissue segmentation device, controller, and methods therefore are disclosed. The device has an active electrode, a return electrode, a mechanical force application mechanism, voltage and current sensors, and a controller. The controller has a processing component, configured to assign a circuit status to a circuit comprising the at least one electrode. IF (PF?0) and ((Vrms/Irms)?T), THEN the circuit status is “open”. IF (PF?0) and ((Vrms/Irms)<T), THEN the circuit status is “short”. PF is a power factor of power applied to the electrosurgical device. T is a threshold value.

Abstract: The present disclosure relates to a new combiner/attenuator circuit that provides improved performance, specifically the combiner/attenuator circuit disclosed is capable of operating at a temperature of 4K and provides an improved frequency response and filtering.

Abstract: A radiofrequency (RF) generator for use with an electrosurgical system includes a shifted, transformed LCLC bandpass filter, configured for allowing the RF generator to operate using a single electrosurgical power setting while preventing overheating of the electrosurgical system. The LCLC bandpass filter may be configured to operate with a specified power curve such that an operating current generated by the RF generator is folded back when approaching short circuit conditions. The RF generator may include a fixed, medical power supply, wherein the specified power curve is modified by switching frequency modulation of the LCLC bandpass filter. Further a method for designing a RF generator for electrosurgical application is disclosed.

Abstract: A cathode active material includes a plurality of cathode active compound particles and a coating disposed over each of the cathode active compound particles. The coating includes a lithium (Li)-ion conducting oxide containing lanthanum (La) and titanium (Ti).

Abstract: Compounds, particles, and cathode active materials that can be used in lithium ion batteries are described herein. Methods of making such compounds, powders, and cathode active materials are described.

Abstract: A cathode active material includes a plurality of cathode active compound particles and a coating disposed over each of the cathode active compound particles. The coating includes a lithium (Li)-ion conducting oxide containing lanthanum (La) and titanium (Ti).

Abstract: Cathode active materials are provided. The cathode active material can include a plurality of cathode active compound particles. A coating is disposed over each of the cathode active compound particles. The coating can include at least one of ZrO2, La2O3, a mixture of Al2O3 and ZrO2 or a mixture of Al2O3 and La2O3. The battery cells that include the cathode active material are also provided.

Abstract: Cathode active materials are provided. The cathode active material can include a plurality of cathode active compound particles. A coating is disposed over each of the cathode active compound particles. The coating can include at least one of ZrO2, La2O3, a mixture of Al2O3 and ZrO2 or a mixture of Al2O3 and La2O3. The battery cells that include the cathode active material are also provided.

Abstract: The present disclosure provides a quantum processing device comprising: one or more functional nanowires, each functional nanowire connected to at least one of a source and a drain; a sensing nanowire spaced from the one or more functional nanowires and connected to at least one of a source and a drain; one or more gate electrodes capacitively coupled with each of the one or more functional nanowires; one or more electrodes capacitively coupled with the sensing nanowire; and a floating coupler positioned between and electrostatically coupling the one or more functional nanowires and the sensing nanowire; and a controller connected to the one or more gates of the sensing nanowire and the one or more gates of the one or more functional nanowires.

Abstract: A data storage medium includes a substrate, and a plurality of spaced-apart discrete data storage tracks supported by the substrate. The data storage medium also includes magnetic flux sinking material between the discrete data storage tracks and over the substrate. As an alternative to the magnetic flux sinking material, plasmonic material may be included between the discrete data storage tracks and over the substrate.

Abstract: A data storage medium includes a substrate, and a plurality of spaced-apart discrete data storage tracks supported by the substrate. The data storage medium also includes magnetic flux sinking material between the discrete data storage tracks and over the substrate. As an alternative to the magnetic flux sinking material, plasmonic material may be included between the discrete data storage tracks and over the substrate.

Abstract: A tissue segmentation device, controller, and methods therefore are disclosed. The device has an active electrode, a return electrode, a mechanical force application mechanism, voltage and current sensors, and a controller. The controller has a processing component, configured to assign a circuit status to a circuit comprising the at least one electrode. IF (PF?0) and ((Vrms/Irms)?T), THEN the circuit status is “open”. IF (PF?0) and ((Vrms/Irms)<T), THEN the circuit status is “short”. PF is a power factor of power applied to the electrosurgical device. T is a threshold value.

Abstract: Described is a macerator and process for using the macerator to reduce the particle size of a particulate containing slurry that is introduced to the macerator.

Abstract: An ultrasonic motion generator includes a non-resonant inverter, an ultrasonic transducer, and a comparator. The non-resonant inverter inverts direct current (DC) to alternating current (AC) having a first frequency. The ultrasonic transducer is electrically coupled with the non-resonant inverter and generates an ultrasonic motion based on the inverted AC. The comparator automatically detects a deviation of the first frequency from a resonant frequency of the ultrasonic transducer based on motion current passing through the ultrasonic transducer and generates an output signal based on the deviation to drive the non-resonant inverter.

Abstract: Compounds, particles, and cathode active materials that can be used in lithium ion batteries are described herein. Methods of making such compounds, powders, and cathode active materials are described. The particles have a particle size distribution with a D50 ranging from 10 ?m to 20 ?m.

Abstract: Two or more different recording currents are applied to a write coil of a recording head. A first of the two or more currents is a positive current and a second of the two or more currents is a negative current. In response to the application of the two or more different recording currents, a data stream is recorded to regions of a moving continuous magnetic recording medium such that each region has three or more magnetic states. The three or more magnetic states can be read from the continuous magnetic recording medium via a magnetic read transducer to recover the data stream.

Abstract: Cell culture devices, and related methods and kits, for modeling isotropic-to-anisotropic cellular transitions are provided. The devices can include a substrate having an isotropic film surface with one or more regions of aligned fibers dispersed thereon.