Abstract: The present invention relates to a pharmaceutical aqueous formulation comprising 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea, or a pharmaceutically acceptable organic or inorganic acid salt thereof, a pharmaceutically acceptable organic or inorganic acid, a pharmaceutically acceptable beta- or gamma-cyclodextrin and water, that is a clear solution, with the proviso that the organic or inorganic acid (including a salt thereof) is not a sulphonic acid. Such a formulation is particularly suitable for intravenous or parenteral administration to a patient.

Abstract: A system includes one or more memory devices storing instructions, and one or more processors configured to execute the instructions to perform the steps of a method to dynamically ingest and monitor online products. The method may include receiving access to a webpage, determining whether the webpage includes a predetermined template, and in response to receiving the predetermined template, ingesting one or more product images and product metadata from the webpage. If no template is found, the system may request search engine optimization metadata to determine if at least one image is of a product before initializing a machine learning algorithm to determine whether the images correspond to product images. If no associated metadata is found, the system may request manual input of associated metadata before displaying, in real-time and in a standardized format, the ingested photos and metadata, allowing a user to select photos representing products of interest.

Abstract: Provided herein are, inter alia, fusion proteins, compositions and methods for manipulation of genomes of living organisms.

Abstract: A system and device for use in open or minimally invasive surgical procedures, such as a bone implant fixation procedure. The device is configured to perform various functions during a bone implant fixation procedure, including performing at least one of: penetration of a bone to form a hole or opening for receipt of a screw; neuromonitoring, in cooperation with a neuromonitoring device, of the hole during, or post-, formation of the hole so as to sense any nearby nerves adjacent to the hole that may be in the path of a screw, or otherwise affected, when a screw is placed within the hole; neurostimulation, in cooperation with a neuromonitoring device, of nerves adjacent to the hole during, or post-, formation of the hole; and measuring of a depth of the hole and providing a digital measurement of the depth to assist the surgeon in selecting the appropriate length of screw.

Abstract: Process control systems for operating process plants are disclosed herein. The process control systems include control modules that are decoupled from the I/O architecture of the process plants using signal objects or generic shadow blocks. This decoupling is effected by using the signal objects or generic shadow blocks to manage at least part of the communication between the control modules and the field devices. Signal objects may convert between protocols used by control modules and field devices, thus decoupling the control modules from the I/O architecture. Generic shadow blocks may be automatically configured to mimic the operation of field devices within a controller executing the control modules, thus partially decoupling the control modules from the I/O architecture by using the shadow blocks to manage communication between the control modules and the field devices.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting an ATXN2 gene, as well as methods of inhibiting expression of an ATXN2 gene and methods of treating subjects having an ATXN2-associated neurodegenerative disease or disorder, e.g., SCAs and ALS, using such dsRNAi agents and compositions.

Abstract: Compounds, particles, and cathode active materials that include lithium, cobalt, manganese, nickel, aluminum, and other elements can be used in lithium ion batteries. The cathode active materials include compounds having the general Formula (I): compound represented by Formula (I): Li?CO1-x-y-zMewMnxNiyAlzO?, as well as Formula (II): Li?CO1-s-u-vMesMntNiuAlyO?.

Abstract: A multilayer structure for a printed wiring board (PWB) includes a plurality of insulating layers interleaved with a plurality of conductive layers including one or more inner conductive layers, a top conductive layer, and a bottom conductive layer. The multilayer structure also includes at least one through-hole through the plurality of insulating layers and the plurality of conductive layers. The multilayer structure also includes at least one secondary material layer formed on at least one inner conductive trace or a terminating land having a surface and an edge near one of the at least one through-hole, the at least one secondary material layer after being removed partially defining a recess that allows plating on both the edge and the surface of the at least one inner conductive trace or the terminating land.

Abstract: The invention is a system and a device for use in open or minimally invasive surgical procedures, such as a bone implant fixation procedure. The device is configured to perform various functions during a bone implant fixation procedure, including performing at least one of: penetration of a bone to form a hole or opening for receipt of a screw; neuromonitoring, in cooperation with a neuromonitoring device, of the hole during, or post-, formation of the hole so as to sense any nearby nerves adjacent to the hole that may be in the path of a screw, or otherwise affected, when a screw is placed within the hole; neurostimulation, in cooperation with a neuromonitoring device, of nerves adjacent to the hole during, or post-, formation of the hole; and measuring of a depth of the hole and providing a digital measurement of the depth to assist the surgeon in selecting the appropriate length of screw.

Abstract: One aspect of the invention provides a three-dimensional scaffold including at least one layer of highly-aligned fibers. The at least one layer of highly-aligned fibers is curved in a direction substantially perpendicular to a general direction of the fibers. Another aspect of the invention provides a method for fabricating a three-dimensional scaffold. The method includes: electro spinning a plurality of fibers to produce at least one layer of highly-aligned fibers and forming the at least one layer of highly-aligned fibers into a three-dimensional scaffold without disturbing the alignment of the highly-aligned polymer fibers. A further aspect of the invention provides methods for using a three-dimensional scaffold to treat nerve or spinal cord injury.

Abstract: A macerator includes a housing that defines a chamber, an inlet and an outlet, the inlet to receive a flow of slurry; two or more elongate concentric bodies located within the chamber defining a gap between the surface of the outer body and the inner surface of the housing, at least one of the bodies rotatable about an axis, and each body comprising a plurality of apertures defining a flow path through each body; a baffle(s) that extend substantially the width of the gap to define a first portion containing the inlet, and a second portion containing the outlet, baffle(s) substantially inhibiting passage of slurry between the two portions via the gap such that the slurry is directed through the body apertures; a motor to drive the rotating body(ies); one or more injectors that inject liquid into the gap, at least one injector located in the first portion.

Abstract: A tissue segmentation device, controller, and methods therefore are disclosed. The device has an active electrode, a return electrode, a mechanical force application mechanism, voltage and current sensors, and a controller. The controller has a processing component, configured to assign a circuit status to a circuit comprising the at least one electrode. IF (PF?0) and ((Vrms/Irms)?T), THEN the circuit status is “open”. IF (PF?0) and ((Vrms/Irms)<T), THEN the circuit status is “short”. PF is a power factor of power applied to the electrosurgical device. T is a threshold value.

Abstract: The present disclosure relates to a new combiner/attenuator circuit that provides improved performance, specifically the combiner/attenuator circuit disclosed is capable of operating at a temperature of 4K and provides an improved frequency response and filtering.

Abstract: A radiofrequency (RF) generator for use with an electrosurgical system includes a shifted, transformed LCLC bandpass filter, configured for allowing the RF generator to operate using a single electrosurgical power setting while preventing overheating of the electrosurgical system. The LCLC bandpass filter may be configured to operate with a specified power curve such that an operating current generated by the RF generator is folded back when approaching short circuit conditions. The RF generator may include a fixed, medical power supply, wherein the specified power curve is modified by switching frequency modulation of the LCLC bandpass filter. Further a method for designing a RF generator for electrosurgical application is disclosed.

Abstract: A cathode active material includes a plurality of cathode active compound particles and a coating disposed over each of the cathode active compound particles. The coating includes a lithium (Li)-ion conducting oxide containing lanthanum (La) and titanium (Ti).

Abstract: Compounds, particles, and cathode active materials that can be used in lithium ion batteries are described herein. Methods of making such compounds, powders, and cathode active materials are described.

Abstract: A cathode active material includes a plurality of cathode active compound particles and a coating disposed over each of the cathode active compound particles. The coating includes a lithium (Li)-ion conducting oxide containing lanthanum (La) and titanium (Ti).

Abstract: Cathode active materials are provided. The cathode active material can include a plurality of cathode active compound particles. A coating is disposed over each of the cathode active compound particles. The coating can include at least one of ZrO2, La2O3, a mixture of Al2O3 and ZrO2 or a mixture of Al2O3 and La2O3. The battery cells that include the cathode active material are also provided.

Abstract: Cathode active materials are provided. The cathode active material can include a plurality of cathode active compound particles. A coating is disposed over each of the cathode active compound particles. The coating can include at least one of ZrO2, La2O3, a mixture of Al2O3 and ZrO2 or a mixture of Al2O3 and La2O3. The battery cells that include the cathode active material are also provided.

Abstract: A data storage medium includes a substrate, and a plurality of spaced-apart discrete data storage tracks supported by the substrate. The data storage medium also includes magnetic flux sinking material between the discrete data storage tracks and over the substrate. As an alternative to the magnetic flux sinking material, plasmonic material may be included between the discrete data storage tracks and over the substrate.