Abstract: Systems and methods are disclosed for disseminating updates of product information documents on a server to a plurality of clients. One exemplary method comprises: receiving updates to a plurality of prescription drug package insert (PDPI) documents; storing the updated versions of the PDPI documents; building an update package specific to one of the clients; including a package manifest in the update package; and transmitting the update package to the client upon a request from the client. The updates are received from a plurality of providers. Storing the updated versions replaces the corresponding existing PDPI documents. The update package include at least one PDPI update.