Abstract: The invention relates to a recombinant expression system for the treatment of cancer based on the “Stimulator of interferon genes” (STING) and comprising two nucleic acid constructs. The invention further relates to an expression vector or a combination of two expression vectors encoding said nucleic acid construct(s) and to a viral particle or a combination of two viral particles comprising said expression vector(s). The invention also relates to a pharmaceutical composition that comprises said recombinant expression system, said expression vector(s) or said viral particle(s). The invention also relates to the use of said recombinant expression system, said expression vector(s), said viral particle(s) or said pharmaceutical composition for use in an immunotherapy, especially in the immunotherapy of a proliferative disorder like cancer. The invention finally relates to the administration of the expression vectors in combination with radiotherapy for the treatment of cancer.

Abstract: The invention relates to an expression system comprising a first and/or a second nucleic acid construct, particularly for use in a combined gene and radiation therapy for the treatment of diseases, especially cancer. The first nucleic acid construct encodes for a target STING, that is responsive to a STING agonist recognizing said target STING but not the human STING and natural variants thereof, wherein said sequence encoding the target STING is operatively linked to elements allowing expression and/or translation of said target STING. The second nucleic acid construct comprise a therapeutic gene sequence which is operatively linked to a STING responsive promoter. Said expression system is administered to a target tissue or organ that received prior, concurrent or afterwards low dose radiation and is followed or not by another round of radiation therapy and/or treatment with a STING agonist.

Abstract: Systems, methods, and computer-readable storage media for enabling secure transfer of Internet domains between registrars. An example method can include receiving, at a registry, a request from a first registrar for information associated with an object recorded in the registry and registered by the first registrar, then generating, at the registry, an authorization code, the authorization code having an expiration. The registry can then transmit, to the first registrar, the authorization code, which in turn can be given to the registrant. The registrant can forward the authorization code to the second registrar, and the registry can receive, from a second registrar before the expiration has been reached: the authorization code and a transfer request for the object, the transfer request identifying a transfer of the object from the first registrar to the second registrar.

Abstract: The present application relates to sustained release formulations of crystalline drugs, comprising a crystalline drug core and a polymer shell, wherein the polymer comprises PLA and/or PLGA and the shell completely encapsulates the core. The sustained release formulations are suitable for drugs such as steroid or proteins. The present invention also relates to methods of the manufacture of the sustained release formulations, using either pressing alone or pressing in combination with heating.

Abstract: A method of providing domain name system (“DNS”) eligibility is provided. The method includes obtaining, at an eligibility service comprising at least one electronic server computer communicatively coupled to a computer network, a request of an eligibility proof from a DNS client; validating, by the eligibility service, the request; providing, by the eligibility service, the eligibility proof to the DNS client; obtaining, by the eligibility service, the eligibility proof, wherein the eligibility proof is related to a registration of a domain name by the DNS client with a DNS registry; validating, by the eligibility service, the eligibility proof; applying, by the eligibility service, a promotion credit to an account of the DNS client; and providing, by the eligibility service, a confirmation of the promotion credit to the DNS client.

Abstract: System, apparatus, methods, and computer-readable medium for generating a verification code related to a registry operation request are provided. A verification process may be performed to determine if a verification request related to a registry operation is to be approved. If the request is to be approved, a verification code is generated that includes identifying information of a verification service provider and a code indicating that the request has been verified.

Abstract: A travel case for a bar of soap is provided. In various embodiments, the travel case permits accelerated drying of the bar of soap and prolongs the life of the soap. The travel case is designed to maintain the bar of soap in a fixed horizontal and vertical position during transport. The travel case includes a lid and a base with a walled receiving portion. The receiving portion is configured to receive a bar of soap that is attached to a soap support and hold the soap support such that the bar of soap is prevented from contacting the surface of the soap case. A method of reversibly securing a bar of soap within a soap case while maintaining the soap in a fixed horizontal and vertical position is also provided herein.

Abstract: System, apparatus, methods, and computer-readable medium for generating a verification code related to a registry operation request are provided. A verification process may be performed to determine if a verification request related to a registry operation is to be approved. If the request is to be approved, a verification code is generated that includes identifying information of a verification service provider and a code indicating that the request has been verified.

Abstract: Systems, methods, and computer-readable storage media for enabling secure transfer of Internet domains between registrars. An example method can include receiving, at a registry, a request from a first registrar for information associated with an object recorded in the registry and registered by the first registrar, then generating, at the registry, an authorization code, the authorization code having an expiration. The registry can then transmit, to the first registrar, the authorization code, which in turn can be given to the registrant. The registrant can forward the authorization code to the second registrar, and the registry can receive, from a second registrar before the expiration has been reached: the authorization code and a transfer request for the object, the transfer request identifying a transfer of the object from the first registrar to the second registrar.

Abstract: In some examples, a method for validating a consistency of sponsorship can include determining, by a DNS registry, that a second-level domain label of a requested domain name in a first top level domain is related to a second-level domain label of an existing domain name in a second top level domain that is grouped in a top level domain database with the first top level domain. The method can also include validating whether there is consistency of sponsorship between the requested domain name in the first top level domain and the existing domain name in the second top level domain. Additionally, the method can include performing an action related to the requested domain name in the first top level domain if there is consistency of sponsorship. Furthermore, the method can include providing results of the request to a client device.

Abstract: A system for allocating domain name acquisition resources is provided. The system performs a method comprising: obtaining, at a database, a list of domain names that are to be deleted during a first time window; updating a drop catch table in the database, wherein the drop catch table comprises a second list of domain names that are to be deleted; refreshing a cache in an application server that provides DNS services based on the drop catch table; obtaining, at the application server, a EPP command from a registrar to register a domain name from the drop catch table that is about to be deleted during a second time window; determining, based on the cache, that the domain name to be registered is available to be registered; updating a flag for the domain name in the cache indicating that the domain name is registered; and providing an acknowledgment to the registrar.

Abstract: In some examples, a method for validating a consistency of sponsorship can include determining, by a DNS registry, that a second-level domain label of a requested domain name in a first top level domain is related to a second-level domain label of an existing domain name in a second top level domain that is grouped in a top level domain database with the first top level domain. The method can also include validating whether there is consistency of sponsorship between the requested domain name in the first top level domain and the existing domain name in the second top level domain. Additionally, the method can include performing an action related to the requested domain name in the first top level domain if there is consistency of sponsorship. Furthermore, the method can include providing results of the request to a client device.

Abstract: A system for allocating domain name acquisition resources is provided. The system performs a method comprising: obtaining, at a database, a list of domain names that are to be deleted during a first time window; updating a drop catch table in the database, wherein the drop catch table comprises a second list of domain names that are to be deleted; refreshing a cache in an application server that provides DNS services based on the drop catch table; obtaining, at the application server, a EPP command from a registrar to register a domain name from the drop catch table that is about to be deleted during a second time window; determining, based on the cache, that the domain name to be registered is available to be registered; updating a flag for the domain name in the cache indicating that the domain name is registered; and providing an acknowledgment to the registrar.

Abstract: Systems, methods, and computer-readable storage media for enabling secure transfer of Internet domains between registrars. An example method can include receiving, at a registry, a request from a first registrar for information associated with an object recorded in the registry and registered by the first registrar, then generating, at the registry, an authorization code, the authorization code having an expiration. The registry can then transmit, to the first registrar, the authorization code, which in turn can be given to the registrant. The registrant can forward the authorization code to the second registrar, and the registry can receive, from a second registrar before the expiration has been reached: the authorization code and a transfer request for the object, the transfer request identifying a transfer of the object from the first registrar to the second registrar.

Abstract: A method of providing domain name system (“DNS”) eligibility is provided. The method includes obtaining, at an eligibility service comprising at least one electronic server computer communicatively coupled to a computer network, a request of an eligibility proof from a DNS client; validating, by the eligibility service, the request; providing, by the eligibility service, the eligibility proof to the DNS client; obtaining, by the eligibility service, the eligibility proof, wherein the eligibility proof is related to a registration of a domain name by the DNS client with a DNS registry; validating, by the eligibility service, the eligibility proof; applying, by the eligibility service, a promotion credit to an account of the DNS client; and providing, by the eligibility service, a confirmation of the promotion credit to the DNS client.

Abstract: A method of providing domain name system (“DNS”) eligibility is provided. The method includes obtaining, at an eligibility service comprising at least one electronic server computer communicatively coupled to a computer network, a request of an eligibility proof from a DNS client; validating, by the eligibility service, the request; providing, by the eligibility service, the eligibility proof to the DNS client; obtaining, by the eligibility service, the eligibility proof, wherein the eligibility proof is related to a registration of a domain name by the DNS client with a DNS registry; validating, by the eligibility service, the eligibility proof; applying, by the eligibility service, a promotion credit to an account of the DNS client; and providing, by the eligibility service, a confirmation of the promotion credit to the DNS client.

Abstract: Provided is a method for providing a response to a user query for domain-related information of a domain. The method can include obtaining, at a client over a network, the user query for the domain-related information, and identifying one or more thick services based on thin data for the domain. The method can also include providing, by the client, the user query to the identified one or more thick services and obtaining a first answer to the user query from the one or more thick services. Furthermore, the method can include providing a second answer to a user based on the first answer.

Abstract: Provided is a method for providing a response to a user query for domain-related information of a domain. The method can include obtaining, at a client over a network, the user query for the domain-related information, and identifying one or more thick services based on thin data for the domain. The method can also include providing, by the client, the user query to the identified one or more thick services and obtaining a first answer to the user query from the one or more thick services. Furthermore, the method can include providing a second answer to a user based on the first answer.

Abstract: Systems, methods, and computer-readable storage media for enabling secure transfer of Internet domains between registrars. An example method can include receiving, at a registry, a request from a first registrar for information associated with an object recorded in the registry and registered by the first registrar, then generating, at the registry, an authorization code, the authorization code having an expiration. The registry can then transmit, to the first registrar, the authorization code, which in turn can be given to the registrant. The registrant can forward the authorization code to the second registrar, and the registry can receive, from a second registrar before the expiration has been reached: the authorization code and a transfer request for the object, the transfer request identifying a transfer of the object from the first registrar to the second registrar.

Abstract: Systems and methods for creating a new domain, such as a top-level domain or a second-level domain, make use of a Domain Manager that enables a user to enter data that is necessary or optional to implement the creation of a new domain. Systems such as, for example, a Registry and one or more Registrars, may use the data defined by the Domain Manager to create a new domain.