Abstract: A traffic control management system includes a secondary traffic signal control system operable to perform operations including: training ML models based on a training data set comprising traffic data to thereby obtain trained ML models, capturing traffic sensor data at the one or more neighboring/adjacent traffic intersections, deploying the trained ML models to predict traffic flow and determine an optimum traffic signal state at the traffic intersection based on the captured traffic sensor data, executing virtual emulation code to virtually emulate the traffic light apparatus and thereby obtain a virtually emulated traffic light apparatus, and autonomously controlling operation of the traffic light apparatus based on the determined optimum traffic signal state by linking a primary traffic signal controller of the primary traffic signal control system to the virtually emulated traffic light apparatus.

Abstract: A eukaryotic host cell engineered to produce a heterologous protein of interest (POI), which cell is genetically modified to reduce production of at least one of three different endogenous host cell protein (HCP), and its use in a method of producing the POI.

Abstract: Methods of dewatering tailings, including tailings streams that may include a clay, ultra-fine particles, or both. The methods may include providing a tailings stream, dewatering the tailings stream with a dewatering apparatus to produce a first cake and a first residual effluent stream, contacting the first residual effluent stream with one or more additives, and dewatering the first residual effluent stream with a solid bowl centrifuge to produce a second cake and a second residual effluent stream. The methods may include providing a tailings stream, contacting the tailings stream with one or more additives, and dewatering the tailings stream with a solid bowl centrifuge to produce a first cake and a first residual effluent stream.

Abstract: Methods of dewatering tailings, including tailings streams that may include a clay, ultra-fine particles, or both. The methods may include providing a tailings stream, dewatering the tailings stream with a dewatering apparatus to produce a first cake and a first residual effluent stream, contacting the first residual effluent stream with one or more additives, and dewatering the first residual effluent stream with a solid bowl centrifuge to produce a second cake and a second residual effluent stream. The methods may include providing a tailings stream, contacting the tailings stream with one or more additives, and dewatering the tailings stream with a solid bowl centrifuge to produce a first cake and a first residual effluent stream.

Abstract: Disclosed are techniques and a device operable to determine a total amount of insulin delivered to the user over a predetermined time period. The total amount of insulin includes a total basal dosage delivered in basal dosages and a total bolus dosage delivered in bolus dosages over the predetermined time period. A proportion of the total amount of insulin delivered to the user provided via the total basal dosage amount over the predetermined time period is calculated. In response determining the proportion of the total amount of insulin attributed to the total basal dosage amount of insulin exceeds a threshold, an average basal dosage to be delivered within a subsequent time period that is approximately equal to the threshold may be determined. An instruction may be generated and output to deliver a modified basal dosage that substantially maintains the average basal dosage over the subsequent time period.

Abstract: The present disclosure relates to nanoparticles comprising a payload and a conjugate having the structure of formula (I):

Abstract: Disclosed are techniques and a device operable to determine a total amount of insulin delivered to the user over a predetermined time period. The total amount of insulin includes a total basal dosage delivered in basal dosages and a total bolus dosage delivered in bolus dosages over the predetermined time period. A proportion of the total amount of insulin delivered to the user provided via the total basal dosage amount over the predetermined time period is calculated. In response determining the proportion of the total amount of insulin attributed to the total basal dosage amount of insulin exceeds a threshold, an average basal dosage to be delivered within a subsequent time period that is approximately equal to the threshold may be determined. An instruction may be generated and output to deliver a modified basal dosage that substantially maintains the average basal dosage over the subsequent time period.

Abstract: Methods and systems for classification and recovery of certain solids from streams, such as liquid waste streams. Methods including classification with at least one solid bowl centrifuge, followed by a valorization procedure. The valorization procedure may be a flotation procedure, which may include a single-step or two-step procedure.

Abstract: The present application is directed to methods for modulating afucosylation of an antibody product that is produced in a bioreactor. The methods include the addition of mannose to the bioreactor to control the afucosylation of the antibody product, including increasing by afucosylation by 1% or more, relative to untreated bioreactor products.

Abstract: Methods of dewatering tailings, including tailings streams that may include a clay, ultra-fine particles, or both. The methods may include providing a tailings stream, dewatering the tailings stream with a dewatering apparatus to produce a first cake and a first residual effluent stream, contacting the first residual effluent stream with one or more additives, and dewatering the first residual effluent stream with a solid bowl centrifuge to produce a second cake and a second residual effluent stream. The methods may include providing a tailings stream, contacting the tailings stream with one or more additives, and dewatering the tailings stream with a solid bowl centrifuge to produce a first cake and a first residual effluent stream.

Abstract: Disclosed are processes and techniques for a correction factor determination process for determining a correction factor for delivering a drug to a patient via a drug delivery device. For example, for an insulin delivery device, the disclosed techniques enable adjustment of the patient’s correction factor in real time based on the deviation of the patient’s glucose concentrations against clinically recommended targets. For example, a method for determining a correction factor may include determining an insulin action (Iaction) for a patient over a duration, the insulin action representing a total insulin metabolized, determining glucose information for the patient over the duration, the glucose information representing glucose activity, and determining an estimated correction factor (CFest) based on (glucose information) / (insulin action) for the duration. Other embodiments are described.

Abstract: The present invention provides novel heterocylic amide compounds having useful antimycobacterial activity. Use of these compounds as pharmaceutical compositions and method of their production are also provided.

Abstract: A system, the system including one or more sensors arranged to detect an area in a proximity of a vehicle and a controller communicatively coupled to the one or more sensors. The controller is configured to determine that an ignition switch of the vehicle is turned off, determine that a user within the proximity of the vehicle based on data from the one or more sensors, determine that an object is approaching the vehicle based on the data, and alert the user of the object.

Abstract: A system, the system including one or more sensors arranged to detect an area in a proximity of a vehicle and a controller communicatively coupled to the one or more sensors. The controller is configured to determine that an ignition switch of the vehicle is turned off, determine that a user within the proximity of the vehicle based on data from the one or more sensors, determine that an object is approaching the vehicle based on the data, and alert the user of the object.

Abstract: Disclosed are techniques and a device operable to determine a total amount of insulin delivered to the user over a predetermined time period. The total amount of insulin includes a total basal dosage delivered in basal dosages and a total bolus dosage delivered in bolus dosages over the predetermined time period. A proportion of the total amount of insulin delivered to the user provided via the total basal dosage amount over the predetermined time period is calculated. In response determining the proportion of the total amount of insulin attributed to the total basal dosage amount of insulin exceeds a threshold, an average basal dosage to be delivered within a subsequent time period that is approximately equal to the threshold may be determined. An instruction may be generated and output to deliver a modified basal dosage that substantially maintains the average basal dosage over the subsequent time period.

Abstract: There is disclosed a system and method for issuing digital securities, In an embodiment, the method comprises: generating in a blockchain network one or more digital securities tokens representing a tradeable royalty unit governed by a royalty smart contract; managing distribution of the one or more digital securities tokens via one or more nodes participating in the blockchain network; and utilizing one or more nodes outside the blockchain network to enable participation in a royalty pool of the one or more digital securities tokens by a plurality of unitholders outside the blockchain network.

Abstract: In various embodiments, a name server transmits a canonical name as resolution to another canonical name. In operation, when a resource name is requested for resolution, a determination is made that the resource name corresponds to a trap resource name. A first canonical name is transmitted as resolution to the trap resource name. The first canonical name is requested for resolution, and a second canonical name is transmitted as resolution. By providing trap canonical names as resolutions to trap canonical names, unauthorized software making the resolution requests is kept occupied with requesting resolution of canonical name after canonical name, impeding the ability of the unauthorized software from traversing a network.

Abstract: The present invention provides novel heterocylic amide compounds having useful antimycobacterial activity. Use of these compounds as pharmaceutical compositions and method of their production are also provided.

Abstract: A eukaryotic host cell engineered to produce a heterologous protein of interest (POI), which cell is genetically modified to reduce production of at least one of three different endogenous host cell protein (HCP), and its use in a method of producing the POI.

Abstract: There is disclosed a system and method for executing multifaceted, multiparty transactions on a Blockchain network. In an aspect, there is disclosed a computer system which, together with other computer systems, participates as a node in a distributed Blockchain network. Each of the computer systems participating as a node in the Blockchain network and participating in a multifaceted, multiparty transaction includes storage adapted to store one or more data models required for modeling the multifaceted transaction between multiple parties participating in the Blockchain network, and a processor for dynamically instantiating the one or more data models to execute the multifaceted, multiparty transaction.