Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.

Abstract: Described are systems, methods, and apparatus that detect keywords in one or more speech segments to authenticate that the speech is generated by the speaker as part of an intentional enrollment by the speaker into a service. For example, as a speech segment is received as part of an enrollment process, the speech segment may be converted into a log melspectrogram and the log melspectrogram may be processed using a machine learning model to determine if an expected keyword is represented by the log melspectrogram. If the keyword is detected, it may be determined that the speech output by the speaker is output as part of an intentional enrollment process.

Abstract: Techniques to facilitate protection of data resources from unauthorized access are disclosed herein. In at least one implementation, a data shield server instructs a user to replace an address and a port associated with a data resource with an updated address associated with the data shield server and a unique port that is uniquely assigned to the user. A request from the user to access the data resource is received at the updated address associated with the data shield server and on the unique port that is uniquely assigned to the user. In response to the request, the user is authenticated using multi-factor authentication to verify that an identity of the user that submitted the request matches the user assigned to the unique port on which the request was received. Upon successful authentication, the data shield server operates as a proxy to connect the user through to the data resource.

Abstract: Described herein are systems, methods for detecting gaps between lesions formed in tissue during ablation. A system includes a catheter that has proximal section, a distal section, and a shaft coupled between the proximal section and the distal section. A plurality of optical fibers are located within the catheter and are coupled to a computing device. The computing device includes a memory and a processor configured to receive, from the optical fibers, optical measurement data of a portion of tissue during or after an ablation, identify one or more optical properties of the portion of tissue by analyzing the optical measurement data, and detect a presence or an absence of a gap between one or more lesions formed in the portion of tissue based on the one or more optical properties.

Abstract: Disclosed herein are system, method, and computer-readable medium aspects for assessing ablation lesions in realtime. An aspect operates by receiving a first optical measurement data from a first catheter optical port, assigning the first optical measurement data to a first available processing core in a processing unit in order to identify an optical property at a first location of a lesion, and generating a first graphical representation from the optical property at the first location of the lesion. After a predetermined time, the aspect continues to operate by repeating the receiving, assigning, and generating operations for a second optical measurement data using a second available processing core in order to generate a second graphical representation from the optical property at a second location of the lesion. The aspect concludes by displaying the first graphical representation and the second graphical representation on a user interface at a predefined interval.

Abstract: Disclosed herein are system, method, and computer-readable medium aspects for improving the accuracy of an ablation model through synchronization. An aspect operates by activating a catheter energy source, acquiring a catheter energy signal from the catheter energy source, assigning an activation time stamp and deactivation time stamp to the catheter energy signal, and determining a time of ablation based on a time period between the activation time stamp and deactivation time stamp. The aspect continues to operate by acquiring an optical measurement signal from a catheter optical port, assigning an input time stamp and switching time stamp to the optical measurement signal, and processing the optical measurement signal in order to acquire a denaturation result. The aspect concludes by synchronizing the time of ablation and the denaturation result using the time stamps in order to generate a synchronized model and generating an estimated lesion depth from the synchronized model.

Abstract: Systems and methods are disclosed for software security discovery. In certain embodiments, a method may comprise executing a third party software security discovery system, including scanning a directory of a client computing system for executable code, and identifying a service request within the executable code. The method may further comprise decomposing the service request into constituent parts, including a target entity of the service request, and generating a catalog of the client computing system, including third party vendors for the client computing system, based on the target entity.

Abstract: Systems and methods are disclosed for software security analysis. In certain embodiments, a method may comprise identifying a set of potential security vulnerabilities, comparing the potential vulnerabilities to a catalog identifying elements on a client system, and generating risk mitigation advice based on potential security vulnerabilities matching an element in the catalog. The method may include evaluating a data field of a service request to a third party to determine an expected data type for the field, determining whether the actual data included in the service request matches the expected data type, and quarantining the service request when the actual data does not match the expected data type. The method may comprise operating as a proxy for the service request, including receiving the service request from the client system, evaluating the service request for irregularities, and forwarding the service request to the third party once the irregularities have been addressed.

Abstract: Described herein is a system including a catheter, an optical circuit, a pulsed field ablation energy source, and a processing device. The catheter includes a proximal section, a distal section, and a shaft coupled between the proximal section and the distal section. The optical circuit is configured to transport light at least partially from the proximal section to the distal section and back. The pulsed field ablation energy source is coupled to the catheter and configured to transmit pulsed electrical signals to a tissue sample. The processing device is configured to analyze one or more optical signals received from the optical circuit to determine changes in polarization or phase retardation of light reflected or scattered by the tissue sample, and determine changes in a birefringence of the tissue sample based on the changes in polarization or phase retardation.

Abstract: Systems and techniques for detecting events involving users that occurred at an inventory location, and then using the events to determines states of the inventory location at various times. For instance, a system may generate event data representing first events that occur within an inventory location. The first events may include an associate performing a task, a customer removing an item, a customer returning an item, and/or so forth. The system may then use the event data to determine a state of the inventory location during a second event. In some examples, the state may include a tidy state or an untidy state. If the state includes a tidy state, then the system may generate a listing of items that includes at least one item associated with the second event. However, if the state includes an untidy state, then the system may further process the second event.

Abstract: A flexible tagging and searching system can be configured to associate tags with the input data to enable a search of the input data. The flexible tagging and searching system can receive user data and determine an identifier associated with the user data. The system can compare the identifier with other identifiers to determine that the identifier is unique. After determining that the identifier is unique, the system can associate a critical tag with the user data and store the critical tag in a database. Then the system can associate a non-critical tag with the user data. In some instances, the system can return query results such as a set of tag data and/or a set of data items.

Abstract: A method for monitoring a wheel system by comparing a wheel end temperature to a wheel end temperature threshold; generating a brake monitoring signal when at least one brake monitoring condition has occurred; and generating a wheel monitoring signal if a brake monitoring signal is generated when the wheel end temperature is greater than the wheel end temperature threshold. The brake monitoring conditions may include (i) a brake supply pressure is less than a brake supply pressure threshold; (ii) a brake control pressure is greater than a first brake control pressure threshold and a stop lamp power signal is not present; and/or (iii) the stop lamp power signal is present and the brake control pressure is not greater than a second brake control pressure threshold. A brake monitoring system configured to monitor a wheel system.

Abstract: Described herein is a system including a catheter, an optical circuit, a pulsed field ablation energy source, and a processing device. The catheter includes a proximal section, a distal section, and a shaft coupled between the proximal section and the distal section. The optical circuit is configured to transport light at least partially from the proximal section to the distal section and back. The pulsed field ablation energy source is coupled to the catheter and configured to transmit pulsed electrical signals to a tissue sample. The processing device is configured to analyze one or more optical signals received from the optical circuit to determine changes in polarization or phase retardation of light reflected or scattered by the tissue sample, and determine changes in a birefringence of the tissue sample based on the changes in polarization or phase retardation.

Abstract: Techniques to facilitate protection of data resources from unauthorized access are disclosed herein. In at least one implementation, a data shield server instructs a user to replace an address and a port associated with a data resource with an updated address associated with the data shield server and a unique port that is uniquely assigned to the user. A request from the user to access the data resource is received at the updated address associated with the data shield server and on the unique port that is uniquely assigned to the user. In response to the request, the user is authenticated using multi-factor authentication to verify that an identity of the user that submitted the request matches the user assigned to the unique port on which the request was received. Upon successful authentication, the data shield server operates as a proxy to connect the user through to the data resource.

Abstract: A tennis ball projecting machine including a support member, a rotatable wheel mounted on one side of the support member, a wheel motor on the other side of the support member, a curved rail below the wheel, a tennis ball hopper above the support member, a surface between the hopper and the machine having a feed opening where at least a portion of the feed opening is on the other side of the support member, and a rotatable body with one or more ball openings that periodically aligns with the feed opening to permit a tennis ball to pass through the feed opening.

Abstract: Described herein is a system including a catheter, an optical circuit, a pulsed field ablation energy source, and a processing device. The catheter includes a proximal section, a distal section, and a shaft coupled between the proximal section and the distal section. The optical circuit is configured to transport light at least partially from the proximal section to the distal section and back. The pulsed field ablation energy source is coupled to the catheter and configured to transmit pulsed electrical signals to a tissue sample. The processing device is configured to analyze one or more optical signals received from the optical circuit to determine changes in polarization or phase retardation of light reflected or scattered by the tissue sample, and determine changes in a birefringence of the tissue sample based on the changes in polarization or phase retardation.

Abstract: A system and method for non-destructive, in situ, positive material identification of a pipe selects a plurality of test areas that are separated axially and circumferentially from one another and then polishes a portion of each test area. Within each polished area, a non-destructive test device is used to collect mechanical property data and another non-destructive test device is used to collect chemical property data. An overall mean for the mechanical property data, and for the chemical property data, is calculated using at least two data collection runs. The means are compared to a known material standard to determine, at a high level of confidence, ultimate yield strength and ultimate tensile strength within +/?10%, a carbon percentage within +/?25%, and a manganese percentage within +/?20% of a known material standard.

Abstract: A system and method for non-destructive, in situ, positive material identification of a pipe selects a plurality of test areas that are separated axially and circumferentially from one another and then polishes a portion of each test area. Within each polished area, a non-destructive test device is used to collect mechanical property data and another non-destructive test device is used to collect chemical property data. An overall mean for the mechanical property data, and for the chemical property data, is calculated using at least two data collection runs. The means are compared to a known material standard to determine, at a high level of confidence, ultimate yield strength and ultimate tensile strength within +/?10%, a carbon percentage within +/?25%, and a manganese percentage within +/?20% of a known material standard.

Abstract: Aqueous dispersions of copolymers of ethylenically unsaturated monomers and silicone resins bearing functional groups which are free radically polymerizable are prepared by forming an aqueous miniemulsion of the silicone resin dissolved in an ethylenically unsaturated monomer, the miniemulsion having a D50 droplet size <350 nm, and polymerizing using a free radical polymerization initiator.

Abstract: A method for monitoring a wheel system by comparing a wheel end temperature to a wheel end temperature threshold; generating a brake monitoring signal when at least one brake monitoring condition has occurred; and generating a wheel monitoring signal if a brake monitoring signal is generated when the wheel end temperature is greater than the wheel end temperature threshold. The brake monitoring conditions may include (i) a brake supply pressure is less than a brake supply pressure threshold; (ii) a brake control pressure is greater than a first brake control pressure threshold and a stop lamp power signal is not present; and/or (iii) the stop lamp power signal is present and the brake control pressure is not greater than a second brake control pressure threshold. A brake monitoring system configured to monitor a wheel system.