Patents by Inventor James H.M. Simon

James H.M. Simon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA deamination mediates innate immunity to (retro)viral infection
    Publication number: 20040009951
    Abstract: Provided is a method of establishing an innate cellular immune defense mechanism against infectious (non-cellular) nucleic acid in a vertebrate or in vertebrate cells, comprising deaminating deoxycytidine (dC) to deoxyuridine (dU) in an infecting viral or retroviral nucleic acid in a dose-dependent manner by introducing a cellular nucleic acid deaminase. Also provided are such nucleic acid deaminases and the gene(s) encoding same, and uses therefore including thereapuetic formulations, methods of treatment, assays and methods of mutagenesis. Included are nucleic acid deaminases from the APOBEC family, in which CEM15 (also known as APOBEC3G) is one such nucleic acid deaminase.
    Type: Application
    Filed: June 13, 2003
    Publication date: January 15, 2004
    Inventors: Michael H. Malim, Ann M. Sheehy, Reuben S. Harris, Kate N. Bishop, Michael S. Neuberger, Nathan C. Gaddis, James H.M. Simon