Abstract: In alternative embodiments, provided are methods for treating and ameliorating a cancer, or recurrence of a cancer such as acute myeloid leukemia (AML) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 (or rebecsinib) and second drug such as an ATP-competitive protein tyrosine kinase inhibitor such as dasatinib. In alternative embodiments, provided are methods for the in vivo inhibition of myeloproliferative neoplasm (MPN) or AML stem cell propagation comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug. In alternative embodiments, provided are methods for the in vivo inhibition pre-leukemia stem cell (pre-LSC) transformation into leukemia stem cells (LSCs) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug.

Abstract: A radar reflector buoy is disclosed comprising a unitary molded inflatable hollow body with an enlarged or thickened portion which is used to attach the buoy to an anchor. The thickened portion includes a mount for an internal staff and corner radar reflector. Also disclosed is a process for producing the radar reflective buoy. The process involved open molding of the attachment area from a liquid unpolymerized polymer, partially curing it with a mount for a radar reflector staff in place, transferring the attachment area to a rotational molding apparatus, inserting a radar corner reflector and rotational molding the buoy body from a compatible powdered polymer.

Abstract: Roller guides made of a ceramic matrix reinforced with monocrystalline whiskers with a cylinder-and-post configuration exhibit long useful operating lives when guiding metallic wires, braids, or ribbons.

Abstract: A novel battery powered lamp is disclosed which includes a hollow housing, a light bulb disposed in the housing for external illumination, a battery in the housing and switch means. In one embodiment, the switch means is a rotary switch having a manually rotatable arm extending through the housing, preferably at the rear end, for movement into and out of contact with a contact plate. In another embodiment, a flexible resilient electrically insulative biasing block is interposed between the bulb and battery and bears contacts. The block preferably supports the bulb while biasing the contacts in place against the bulb and battery. In a third embodiment, the bulb is socketless and has its base embedded in the block so that it is suspended in a transparent portion of the housing. Each embodiment is simple to assemble and use, inexpensive to make and maintain, efficient and durable. All are utilizable as portable flashlights and the like, and are capable of being made weatherproof.

Abstract: A floating seat cushion which is capable of emergency use as a life preserver. The seat cushion comprises a center core of open cell polyurethane foam material surrounded by an outer layer of closed cell polyethylene foam material. A belt extends transversely adjacent one side of the center core to form a pair of loops which extend outwardly from opposite sides of the cushion. The belt is preferably laminated between the center core and outer layer. The cushion is preferably formed by placing the center core outer layer and belt in overlying relationship to each other with adhesive between them. The assembly is then placed in a press and compressed to cause the center core to collapse so that the peripheral portions of the outer layer can be bonded together to enclose the center core. Air is then replaced into the center core to cause the cushion to assume a convex or crown shape. The completed cushion is preferably coated with vinyl.

Abstract: A heat shield for use with freestanding fuel-burning stoves, furnaces, fireplaces and the like, in the form of a modular panel assembly for securance over a wall in spaced relation to said freestanding unit; parallel-spaced, large area, anti-buckling specially-contoured partitions behind the front face of the panel assembly define plural vertical passages layered over the wall for air entering at an intake at the bottom and exiting at an exhaust at the top; louvers at the intake and exhaust align with the respective plural air passages and co-act with the interior partition structure of the invention to produce a sharp thermal gradiant between the front face and any wall protected from a source of heat by the invention, the front face of the panel assembly being hottest, and successive interior partitions and the wall protected being successively cooler as result of convective cooling combined with radiative shielding; special slot and attachment structure further prevents buckling from thermal expansion.

Abstract: A conventional type of life preserver has a rectangular shape, with a circular neck receiving opening adjacent the upper end and a slit extending from the bottom of the opening to the lower edge of the preserver. The invention comprises a strap having one end thereof immovably molded into the preserver and extending from one side edge of the preserver to the slit. A pair of oppositely directed D-ring fastening members are mounted on the strap in recesses directed inwardly from opposite sides of the preserver adjacent to the slit. The portion of the strap past the D-rings slidably extends through a sleeve which is molded into the preserver from the slit to the opposite side edge. The strap has an elongated portion which extends around the body of the wearer, with a buckle on its end which may be selectively attached to either of the rings, depending on the direction in which the preserver is facing.