Patents by Inventor James H. Silver

James H. Silver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9510780
    Abstract: A system is disclosed that extracts bodily fluid to a reaction chamber for monitoring a substance or property of the patient fluid. In one embodiment, a pump is used to advance the sample of bodily fluid through a filter to produce a filtrate. Another pump advances filtrate into the reaction chamber, while another pump advances reactant into the reaction chamber. A sensor in communication with the reaction chamber determines a concentration of nitric oxide or one of its metabolic products. Methods are also disclosed.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: December 6, 2016
    Inventor: James H. Silver
  • Publication number: 20150230742
    Abstract: A system is disclosed that extracts bodily fluid to a reaction chamber for monitoring a substance or property of the patient fluid. In one embodiment, a pump is used to advance the sample of bodily fluid through a filter to produce a filtrate. Another pump advances filtrate into the reaction chamber, while another pump advances reactant into the reaction chamber. A sensor in communication with the reaction chamber determines a concentration of nitric oxide or one of its metabolic products. Methods are also disclosed.
    Type: Application
    Filed: April 30, 2015
    Publication date: August 20, 2015
    Inventor: James H. Silver
  • Patent number: 9044182
    Abstract: A system is disclosed that extracts bodily fluid to a reaction chamber for monitoring a substance or property of the patient fluid. In one embodiment, a pump is used to advance the sample of bodily fluid through a filter to produce a filtrate. Another pump advances filtrate into the reaction chamber, while another pump advances reactant into the reaction chamber. A sensor in communication with the reaction chamber determines a concentration of nitric oxide or one of its metabolic products. Methods are also disclosed.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: June 2, 2015
    Inventor: James H. Silver
  • Patent number: 8609426
    Abstract: A system is disclosed that extracts bodily fluid to a reaction chamber for monitoring a substance or property of the patient fluid. In one embodiment, a pump is used to advance the sample of bodily fluid through a filter to produce a filtrate. Another pump advances filtrate into the reaction chamber, while another pump advances reactant into the reaction chamber. A sensor in communication with the reaction chamber determines a concentration of nitric oxide or one of its metabolic products. Methods are also disclosed.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: December 17, 2013
    Inventor: James H Silver
  • Publication number: 20130202721
    Abstract: A system is disclosed that extracts bodily fluid to a reaction chamber for monitoring a substance or property of the patient fluid. In one embodiment, a pump is used to advance the sample of bodily fluid through a filter to produce a filtrate. Another pump advances filtrate into the reaction chamber, while another pump advances reactant into the reaction chamber. A sensor in communication with the reaction chamber determines a concentration of nitric oxide or one of its metabolic products. Methods are also disclosed.
    Type: Application
    Filed: March 14, 2013
    Publication date: August 8, 2013
    Inventor: James H. Silver
  • Patent number: 8353926
    Abstract: A medical filter has more than one pair of struts extending along an undulating path between a first and second end, which cooperate to define a first and second filter element having a plurality of cells, connected by a central portion with longitudinal strut sections. The struts extend between the first and second ends, and the struts tend to resiliently expand in radially outward directions from a compressed initial shape to an expanded deployed shape. In the expanded shape, the undulating path is defined by (i) a first portion of each pair of ribs extends substantially adjacent to each other for a distance from the first end, (ii) a second portion of each pair of ribs extends substantially adjacent to each other for a distance from the second end; and (iii) an intermediate portion of each one of a pair of ribs extends to curve away from each other.
    Type: Grant
    Filed: April 15, 2005
    Date of Patent: January 15, 2013
    Assignee: Cordis Corporation
    Inventor: James H. Silver
  • Publication number: 20120135531
    Abstract: A system is disclosed that extracts bodily fluid to a reaction chamber for monitoring a substance or property of the patient fluid. In one embodiment, a pump is used to advance the sample of bodily fluid through a filter to produce a filtrate. Another pump advances filtrate into the reaction chamber, while another pump advances reactant into the reaction chamber. A sensor in communication with the reaction chamber determines a concentration of nitric oxide or one of its metabolic products. Methods are also disclosed.
    Type: Application
    Filed: January 26, 2012
    Publication date: May 31, 2012
    Inventor: James H. Silver
  • Patent number: 8133698
    Abstract: A system is disclosed that extracts bodily fluid to a reaction chamber for monitoring a substance or property of the patient fluid. In one embodiment, a pump is used to advance the sample of bodily fluid through a filter to produce a filtrate. Another pump advances filtrate into the reaction chamber, while another pump advances reactant into the reaction chamber. A sensor in communication with the reaction chamber determines a concentration of nitric oxide or one of its metabolic products. Methods are also disclosed.
    Type: Grant
    Filed: January 16, 2008
    Date of Patent: March 13, 2012
    Inventor: James H. Silver
  • Publication number: 20120058012
    Abstract: A system is disclosed that extracts bodily fluid to a reaction chamber for monitoring a substance or property of the patient fluid. In one embodiment, a pump is used to advance the sample of bodily fluid through a filter to produce a filtrate. Another pump advances filtrate into the reaction chamber, while another pump advances reactant into the reaction chamber. A sensor in communication with the reaction chamber determines a concentration of nitric oxide or one of its metabolic products. Methods are also disclosed.
    Type: Application
    Filed: October 20, 2011
    Publication date: March 8, 2012
    Inventors: James H. Silver, Darius F. Mostowfi
  • Patent number: 8114350
    Abstract: A system is disclosed that extracts bodily fluid to a reaction chamber for monitoring a substance or property of the patient fluid. In one embodiment, a pump is used to advance the sample of bodily fluid through a filter to produce a filtrate. Another pump advances filtrate into the reaction chamber, while another pump advances reactant into the reaction chamber. A sensor in communication with the reaction chamber determines a concentration of nitric oxide or one of its metabolic products. Methods are also disclosed.
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: February 14, 2012
    Inventors: James H. Silver, Darius F. Mostowfi
  • Patent number: 7769420
    Abstract: A sensor is disclosed, for implantation within a blood vessel to monitor a substance in or property of blood. In one embodiment, the sensor detects nitric oxide or a nitric oxide metabolite. In another embodiment, other substances such as glutamate, aspartate, arginine, citrulline, acetylcholine, calcium, potassium, or dopamine are monitored. The sensor may be attached to a support structure such as a stent, guidewire, or catheter. In a further embodiment, a catheter is disclosed that extracts patient fluid to a sensor outside the body for monitoring a substance or property of the patient fluid. Methods are also disclosed.
    Type: Grant
    Filed: November 16, 2005
    Date of Patent: August 3, 2010
    Inventors: James H. Silver, Darius F. Mostowfi
  • Publication number: 20090099409
    Abstract: A medical sheet has an intricate pattern of loops, struts and bridges and is made of a super elastic alloy. The medical sheet includes a plurality of amorphic circles which provide rounded surfaces attached to the outer edges which made the medical sheet a-traumatic when implanted. When the medical sheet is cooled the molecular phase becomes martensitic which allows the medical sheet to be compressed for easier insertion into a patient. When the medical sheet is heated, the molecular phase changes to austenitic which causes the medical sheet to expand to a size suitable for implantation. The medical sheet can be secured within the patient by suturing through holes in the amorphic circles.
    Type: Application
    Filed: October 16, 2007
    Publication date: April 16, 2009
    Inventors: Kirsten F. Luehrs, James H. Silver
  • Publication number: 20080275496
    Abstract: A retrievable medical filter which can be placed in a blood vessel or other body passage. The filter has improved structural features for enhancing its filter effectiveness and to facilitate its retrieval from the body passage. The filter has a longitudinal spine with struts extending from each longitudinal to form filter baskets. The ends of the spine to which the struts are attached may be rings with serpentine cuts in the rings to make them expandable. The struts can extend circumferentially as well as radially outwardly to provide a structure which can be radially compressed without bending the struts in a tight radius.
    Type: Application
    Filed: May 1, 2007
    Publication date: November 6, 2008
    Inventors: James A. Fleming, Thomas Frank Kinst, James H. Silver
  • Publication number: 20080275495
    Abstract: An elongated medical filter is radially expandable and compressible and is intended for placement inside a tubular body passage, such as a blood vessel, of a patient. In expanded form, the medical filter has a spine with a retrieval element and a pair of longitudinally spaced filter baskets, one of the filter baskets having a plurality of independent legs and the other of the filter baskets having a plurality of legs with interconnecting struts.
    Type: Application
    Filed: May 1, 2007
    Publication date: November 6, 2008
    Inventor: James H. Silver
  • Publication number: 20080176271
    Abstract: A system is disclosed that extracts bodily fluid to a reaction chamber for monitoring a substance or property of the patient fluid. In one embodiment, a pump is used to advance the sample of bodily fluid through a filter to produce a filtrate. Another pump advances filtrate into the reaction chamber, while another pump advances reactant into the reaction chamber. A sensor in communication with the reaction chamber determines a concentration of nitric oxide or one of its metabolic products. Methods are also disclosed.
    Type: Application
    Filed: January 16, 2008
    Publication date: July 24, 2008
    Inventors: James H. Silver, Darius F. Mostowfi
  • Publication number: 20080033479
    Abstract: A medical filter has more than one pair of struts extending along an undulating path between a first and second end, which cooperate to define a first and second filter element having a plurality of cells, connected by a central portion with longitudinal strut sections. The struts extend between the first and second ends, and the struts tend to resiliently expand in radially outward directions from a compressed initial shape to an expanded deployed shape. In the expanded shape, the undulating path is defined by (i) a first portion of each pair of ribs extends substantially adjacent to each other for a distance from the first end, (ii) a second portion of each pair of ribs extends substantially adjacent to each other for a distance from the second end; and (iii) an intermediate portion of each one of a pair of ribs extends to curve away from each other.
    Type: Application
    Filed: April 15, 2005
    Publication date: February 7, 2008
    Inventor: James H. Silver
  • Patent number: 7181261
    Abstract: A sensor is disclosed, for implantation within a blood vessel to monitor a substance in or property of blood. In one embodiment, the sensor is retrievable. In another embodiment, the sensor has a layer that minimizes the formation of thrombus. A signal representative of the substance in or property of blood is transmitted to an external receiver. In another embodiment, the sensor detects nitric oxide or a nitric oxide metabolite and can be implanted for a period of hours, days, weeks or years. Methods are also disclosed.
    Type: Grant
    Filed: January 15, 2004
    Date of Patent: February 20, 2007
    Inventors: James H. Silver, Darius Fredrick Mostowfi
  • Patent number: 7056550
    Abstract: Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.
    Type: Grant
    Filed: August 7, 2003
    Date of Patent: June 6, 2006
    Assignee: Ethicon, Inc. - USA
    Inventors: Luis A. Davila, David Christian Lentz, Gerard H. Llanos, Jorge Orlando Mendez, Pallassana V. Narayanan, Alan Roy Pelton, Mark B. Roller, Karl K. Scheidt, Angelo George Scopelianos, William Douglas Shaw, Jr., James H. Silver, John Spaltro, Christine Trepanier, David J. Wilson
  • Patent number: 7033322
    Abstract: A sensor is disclosed, for implantation within a blood vessel to monitor an analyte in blood. In one embodiment, the analyte is glucose. A signal indicative of glucose level is transmitted to an external receiver. The signal may also be used to drive an internal or externally worn insulin pump. Methods are also disclosed.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: April 25, 2006
    Inventor: James H. Silver
  • Patent number: 7006858
    Abstract: A sensor is disclosed, for implantation within a blood vessel to monitor an analyte in blood. In one embodiment, the sensor is retrievable. In another embodiment, the sensor is an immunosensor. A signal representative of a reaction between an analyte and an antigen of the analyte is transmitted to an external receiver. Methods are also disclosed.
    Type: Grant
    Filed: August 9, 2002
    Date of Patent: February 28, 2006
    Inventors: James H. Silver, Darius Fredrick Mostowfi