Abstract: This application relates to a building energy analysis and management system for measurement and verification of building performance. The system can analyze, optimize, manage, maintain, trouble shoot, and/or modify building systems, such as HVAC systems, in connection with the building energy usage. Measurements may be gathered for one or more HVAC units coupled to pressure independent valves, and sent to one or more Surge Panels that pass data to remote analysis servers, which can receive other system or external data. The analysis servers compare measurements to predicted values and can standardize the predicted values to account for external conditions. The comparison can result in difference values used to generate probable causes and optimization recommendations. The system outputs reports or other data display using a graphical user interface that can be adjusted for an anticipated user.

Abstract: A server operates between a customer and a subscriber to store data associated with the customer and data comprising media content associated with the subscriber. The server is configured to receive from the customer a request for content associated with products or services provided by the subscriber. The request is triggered by scanning a code by a user device operated by the customer. The request causes the server to retrieve customer information from data storage operated by the server. Based on the retrieved customer information and the request for content from the customer, the server retrieves personalized data associated with the subscriber. The personalized data comprises the media content associated with the subscriber that is tailored based on customer preferences stored in the server.

Abstract: The present disclosure relates to cell penetrating anti-DNA binding proteins. Compositions comprising these binding proteins may be useful for delivering agents to cells and treating diseases such as cancer.

Abstract: Apparatuses, systems, and techniques to indicate resources of reference signals. In at least one embodiment, a system includes one or more processors to transmit an indication of two or more non-uniformly distributed frequencies or time slots of two or more corresponding reference signals to be received by the system.

Abstract: Apparatuses, systems, and techniques to indicate resources of reference signals. In at least one embodiment, a system includes one or more processors to receive an indication of two or more non-uniformly distributed frequencies or time slots of two or more corresponding reference signals to be transmitted by the system.

Abstract: The present disclosure relates to cell penetrating anti-DNA binding proteins. Compositions comprising these binding proteins may be may be useful for delivering agents to cells and treating diseases such as cancer.

Abstract: A system and computer-implemented is provided for displaying a configurable metric relating to an environment in a graphical display along with a value of the metric calculated over a configurable time period. The metric is used to identify events of interest in the environment based on processing real time machine data from one or more sources. The configurable metric is selected and a corresponding value is calculated based on the events of interest over the configurable time period. The value of the metric may be continuously updated in real time based on receiving additional real-time machine data and displayed in a graphical interface as time progresses. Statistical trends in the value of the metric may also be determined over the configurable time period and displayed in the graphical interface as well as an indication if the value of the metric exceeds a configurable threshold value.

Abstract: A compressor assembly for a portable oxygen concentrator includes a first compressor chamber having a first connector, a second compressor chamber having a second connector, and a tube having a first end having a first connection interface configured to connect to the first connector and a second end having a second connection interface configured to connect to the second connector. The first connection interface is shaped to maintain the connection between the first connector and the first connection interface in a fixed orientation and the second connection interface is shaped to maintain the connection between the second connector and the second connection interface in a fixed orientation. One or more of the first connector, the second connector, and the tube are compliant.

Abstract: A battery retaining system for a portable oxygen concentrator includes a first rail configured to receive a first slide of a battery, a second rail configured to receive a second slide of the battery, the second rail being spaced apart from the first rail so as to form a channel configured to receive the battery, and a flexible stiffening mechanism configured to impart a biasing force on a surface of the battery when the battery is received within the channel. The flexible stiffening mechanism includes a protrusion projecting from the first rail at least partially towards the second rail and a slit positioned behind the protrusion and configured to facilitate travel of the protrusion fore and aft.

Abstract: A compressor assembly for a portable oxygen concentrator includes a first compressor chamber having a first connector, a second compressor chamber having a second connector, and a tube having a first end having a first connection interface configured to connect to the first connector and a second end having a second connection interface configured to connect to the second connector. The first connection interface is shaped to maintain the connection between the first connector and the first connection interface in a fixed orientation and the second connection interface is shaped to maintain the connection between the second connector and the second connection interface in a fixed orientation. One or more of the first connector, the second connector, and the tube are compliant.

Abstract: The present disclosure relates to cell penetrating anti-DNA binding proteins. Compositions comprising these binding proteins may be may be useful for delivering agents to cells and treating diseases such as cancer.

Abstract: The disclosure provides methods of treating joint inflammation, including rheumatoid arthritis, in a subject using mo-melotinib (MMB).

Abstract: Apparatuses, systems, and techniques to perform and facilitate an interface for multi-user and/or multi-cell physical layer (PHY) signal processing pipelines in a fifth generation (5G) new radio (NR) network. In at least one embodiment, a software interface facilitates scalable execution of multi-user and/or multi-cell information by a 5G-NR PHY software library implementing one or more signal processing pipelines.

Abstract: Herein disclosed are combinations of Checkpoint Kinase 1 (Chk1) inhibitors and PARP inhibitors useful for inhibiting the growth of tumors such as those in patients with cancer. In particular, the combination demonstrates remarkable synergistic effects on cancer cells that are representative models for tumors. Also provided for are methods for treating disorders or diseases mediated or affected by Chk1 and/or PARP activity.

Abstract: DNA-targeted nanocarriers for encapsulating an active agent and delivering it to extracellular DNA are provided. The nanocarriers, for example, polymeric particles, liposomes, and multilamellar vesicles have targeting moiety that targets DNA conjugated thereto. The targeting moiety that targets DNA is typically an antibody, or variant, fragment, or fusion protein derived therefrom that binds to DNA or nucleosomes. The targeting moiety can be a circulating autoantibody that binds DNA such as those commonly found in patients with SLE. In some embodiments, the targeting moiety is antibody 3E10 or a variant, fragment, or fusion protein derived therefrom. Pharmaceutical compositions, methods of use, and dosage regimens are also provided.

Abstract: In one embodiment, a diagnostic system includes an instrument coupled to a client device and having at least one sample processing bay. The diagnostic system has a software architecture including instrument software (ISW) associated with the instrument. The ISW receives an assay definition file (ADF) that has a control file and an assay analysis module (AAM) file. The processing bay prepares and senses the sample according to parameters in the OPUS file and then generates sensor scan data. The diagnostic system then analyzes the sensor scan data and prepares a report according to the AAM file.

Abstract: A portable oxygen concentrator includes a compressor and a controller. The compressor includes a motor, at least one chamber, and at least one piston operably coupled to the motor and movable within the at least one chamber. In some embodiments, the controller is configured to: determine actual motor speeds for commutations steps of the motor during a first rotational cycle; determine an average motor speed during the first rotational cycle; determine a voltage pattern based at least on a comparison of the average motor speed during the first rotational cycle and the actual motor speeds for the commutation steps of the motor during the first rotational cycle; and cause the voltage pattern to be applied to the motor during a second rotational cycle to reduce differences between applied motor torque and variable torque load imparted by the at least one piston.

Abstract: This disclosure provides methods of using a checkpoint kinase 1 (Chk1) inhibitor in the treatment of cancer in a subject having at least an intermediate tumor mutational burden (TMB), or a genetic abnormality in one or more particular genes associated with replicative stress. Accordingly, methods of treating cancer in a subject having at least an intermediate tumor mutational burden (TMB-I) are provided. Also provided are methods of treating cancer in a subject having a genetic abnormality in one or more particular genes selected from cell cycle regulation genes, replication stress genes, oncogenic driver mutations and DNA damage response and repair network genes. Methods of selecting subjects for Chk1 inhibition therapy are provided. The methods can include administering to the subject an effective amount of a SRA737 compound, in some cases in combination with low dose gemcitabine.

Abstract: Disclosed herein are methods of treatment by administering SRA737 as a monotherapy or in a combination therapy that is useful for treating patients with cancer.

Abstract: In one embodiment, a diagnostic system includes an instrument coupled to a client device and having at least one sample processing bay. The diagnostic system has a software architecture including instrument software (ISW) associated with the instrument. The ISW receives an assay definition file (ADF) that has a control file and an assay analysis module (AAM) file. The processing bay prepares and senses the sample according to parameters in the OPUS file and then generates sensor scan data. The diagnostic system then analyzes the sensor scan data and prepares a report according to the AAM file.