Abstract: A time-ordered series of measurements of a polymer made during translocation of the polymer through a Nanopore are analysed. The measurements are dependent on the identity of k-mers in the Nanopore, a k-mer bring k polymer units of the polymer, where k is a positive integer. The method involves deriving, from the series of measurements, a feature vector of time-ordered features representing characteristics of the measurements; and determining similarity between the derived feature vector and at least one other feature vector.

Abstract: An embodiment of a uterine hemorrhage controlling system comprises a suction module including a suction end coupleable to a pump by a connecting tube, and a sealing module coupled to the suction module. The system may further comprise the pump and a filter coupled to the suction module. A uterine hemorrhage controlling method comprises: shielding a suction module that has been delivered into a uterus; sealing an entrance into the uterus while the suction module is situated within the uterus; applying a negative pressure within the uterus upon activation of a pump; and maintaining the negative pressure within the uterus to induce uterine contraction. The method may further comprise delivering the suction module into the uterus; transmitting bodily fluids, out of the uterus through the suction module, and filtering the bodily fluids.

Abstract: A sequence of polymer units in a polymer (3), eg. DNA, is estimated from at least one series of measurements related to the polymer, eg. ion current as a function of translocation through a nanopore (1), wherein the value of each measurement is dependent on a k-mer being a group of k polymer units (4). A probabilistic model, especially a hidden Markov model (HMM), is provided, comprising, for a set of possible k-mers: transition weightings representing the chances of transitions from origin k-mers to destination k-mers; and emission weightings in respect of each k-mer that represent the chances of observing given values of measurements for that k-mer. The series of measurements is analysed using an analytical technique, eg. Viterbi decoding, that refers to the model and estimates at least one estimated sequence of polymer units in the polymer based on the likelihood predicted by the model of the series of measurements being produced by sequences of polymer units.

Abstract: Systems and methods of controlling temperature in a cabin of an electric vehicle that has an HVAC system powered by a battery system and an auxiliary heating system. Upon determining, by a system controller, that a setpoint temperature is less than or equal to a sensed cabin temperature while operating in an HVAC electric heat state, an auxiliary heat state, or a maximum heat state, automatically transitioning to an off state from the HVAC electric heat state, the auxiliary heat state, or the maximum heat state.

Abstract: The disclosure provides various systems and methods for identifying individuals from one or more samples. In particular, improved systems and methods of analysis are provided for handling multiple contributors, as well as systems and methods that model not only individual error rates per locus but factor in amplification of errors induced through PCR cycles. In some embodiments, modeling of error rates can be applied in multi-contributor settings to more accurately establish real alleles from artifacts. Other aspects involve application of sequencing in error modeling. Further, methods are provided for determining the presence of common individual DNA profiles in one or more complex DNA mixtures and for deconvolution of multiple complex DNA mixtures into shared individual components. The methods of the disclosure do not require any prior knowledge of individual DNA profiles or contributors to the complex DNA mixtures.

Abstract: The disclosure provides various systems and methods for identifying individuals from one or more samples. In particular, improved systems and methods of analysis are provided for handling multiple contributors, as well as systems and methods that model not only individual error rates per locus but factor in amplification of errors induced through PCR cycles. In some embodiments, modeling of error rates can be applied in multi-contributor settings to more accurately establish real alleles from artifacts. Other aspects involve application of sequencing in error modeling. Further, methods are provided for determining the presence of common individual DNA profiles in one or more complex DNA mixtures and for deconvolution of multiple complex DNA mixtures into shared individual components.

Abstract: A temperature control system for an electric vehicle includes a cabin temperature control system configured to control flow of a refrigerant through one or more heat exchangers to control a temperature of a cabin of the electric vehicle, a battery temperature control system configured to control the flow of a coolant through one or more heat exchangers to control a temperature of a battery system of the electric vehicle, and a power electronics temperature control system configured to control the flow of coolant through one or more heat exchangers to control a temperature of one or more power electronics. In a first configuration of the temperature control system, the battery temperature control system and the power electronics temperature control system may be thermally isolated, and, in a second configuration, the battery temperature control system and the power electronics temperature control system may thermally interact.

Abstract: The premixed pilot nozzle includes axially elongated tubes defined within a plenum between an outer shroud and a first shroud disposed radially inward of the outer shroud. The tubes extend between tube inlets defined through a forward face and tube outlets defined through an aft face. A second shroud is disposed radially inward of the first shroud, thereby defining a fuel plenum between the first shroud and the second shroud, and the fuel plenum is in communication with a gaseous fuel supply. A fuel injection port, which is positioned between the tube inlet and the tube outlet of each tube, is in fluid communication with the fuel plenum. An air supply configured to fluidly communicate with the tube inlet of each tube. The second shroud defines a second plenum therein, the second plenum being coupled to a source of a non-combustible fluid.

Abstract: An apprenticeship system enabling all stakeholders involved (apprentice, sponsor/employer, TDA) to access a single system to assist an apprentice through the different phases of apprenticeship journey, including Account Creation, Registration (Application & Preparation), In-Class Training, On-The-Job Training (Personalized Logbook), Membership & Certification and Reporting. An apprenticeship system may be built on a common data model so that information is shared across the system for all users, tasks, and business processes. The system may consolidate all data about the apprentice journey in a single location, allowing for real-time data exchange among stakeholders.

Abstract: A temperature control system for an electric vehicle includes a cabin temperature control system configured to control flow of a refrigerant through one or more heat exchangers to control a temperature of a cabin of the electric vehicle, a battery temperature control system configured to control the flow of a coolant through one or more heat exchangers to control a temperature of a battery system of the electric vehicle, and a power electronics temperature control system configured to control the flow of coolant through one or more heat exchangers to control a temperature of one or more power electronics. In a first configuration of the temperature control system, the battery temperature control system and the power electronics temperature control system may be thermally isolated, and, in a second configuration, the battery temperature control system and the power electronics temperature control system may thermally interact.

Abstract: An injection assembly for a gas turbine combustor having a liner defining a combustion zone and a secondary combustion zone and a forward casing circumferentially surrounding at least a portion of the liner is provided. The injection assembly includes a thimble assembly and an injector unit. The thimble assembly, which is mounted to the liner, includes a thimble that extends through a thimble aperture in the liner. The injector unit, which is mounted to and extends through the forward casing, includes an injector blade that extends into the thimble. The injection assembly introduces a flow of fuel into a flow of air flowing through the thimble, such that fuel and air are injected into the secondary combustion zone in a direction transverse to a flow of combustion products from the primary combustion zone.

Abstract: A gas turbine combustor includes: a head end comprising a primary fuel nozzle; a liner defining a primary combustion zone proximate the head end and a downstream secondary combustion zone; a forward casing radially outward of and surrounding at least a portion of the liner; and an axial fuel staging system. The axial fuel staging system includes a plurality of fuel injection assemblies. Each fuel injection assembly includes a thimble assembly mounted to the liner, and an injector unit attached to the forward casing. A thimble of the thimble assembly extends through a thimble aperture in the liner. The injector unit extends through the forward casing, such that a portion of the injector unit is disposed within the thimble, and a fuel line fitting is disposed outward of the forward casing. The injector unit introduces fuel into air flowing through the thimble for injection into the secondary combustion zone.

Abstract: The disclosure provides various systems and methods for identifying individuals from one or more samples. In particular, improved systems and methods of analysis are provided for handling multiple contributors, as well as systems and methods that model not only individual error rates per locus but factor in amplification of errors induced through PCR cycles. In some embodiments, modeling of error rates can be applied in multi-contributor settings to more accurately establish real alleles from artifacts. Other aspects involve application of sequencing in error modeling. Further, methods are provided for determining the presence of common individual DNA profiles in one or more complex DNA mixtures and for deconvolution of multiple complex DNA mixtures into shared individual components.

Abstract: A temperature control system for an electric vehicle includes a cabin temperature control system configured to control flow of a refrigerant through one or more heat exchangers to control a temperature of a cabin of the electric vehicle, a battery temperature control system configured to control the flow of a coolant through one or more heat exchangers to control a temperature of a battery system of the electric vehicle, and a power electronics temperature control system configured to control the flow of coolant through one or more heat exchangers to control a temperature of one or more power electronics. In a first configuration of the temperature control system, the battery temperature control system and the power electronics temperature control system may be thermally isolated, and, in a second configuration, the battery temperature control system and the power electronics temperature control system may thermally interact.

Abstract: This disclosure relates to systems and methods for tuning combustion dynamics in a combustor. In one embodiment of the disclosure, a method includes providing, via at least one sensor, combustion dynamics amplitude data associated with a combustor. Method may allow monitoring, by an equipment controller communicatively coupled to the at least one sensor, the combustion dynamics amplitude data. The method may allow detecting at least one change in acoustic pressure amplitude associated with combustion in the combustor. In response to detecting the change in the acoustic pressure amplitude, the method proceeds with determining a fuel split change to at least two fuel circuits configured to supply fuel to the combustor, and applying the fuel split change to the combustor.

Abstract: A thimble assembly, which directs fluid flow through a combustor liner, includes a thimble boss and a thimble. The thimble boss is mounted an outer surface of the liner and surrounds a liner opening, thus defining a thimble boss passage. The thimble is disposed through the passage and the liner opening. The thimble wall extends from an inlet portion to an outlet of the thimble. The inlet portion has a greater diameter than the outlet and defines an inlet plane and a parallel intermediate plane. A terminal plane, parallel to the intermediate plane, includes an array of points most distant from a corresponding array of points defining the intermediate plane. The thimble wall has a non-uniform length, such that the outlet of the thimble is oriented at an oblique angle relative to the terminal plane. The thimble wall may have an arcuate shape defined as one-fourth of an ellipse.

Abstract: There is disclosed an acoustic transducer for communications within an operational bandwidth, the transducer comprising: A signal generator for generating a signal at a centre-frequency within the operational bandwidth; A piezoelectric element having a dielectric constant that varies with temperature; A driving electrode at the surface of the piezoelectric element; A matching network, having a natural frequency at a given temperature, and operable to transfer the signal from the signal generator to the piezoelectric element whilst mitigating electrical loss, the matching network being connected to the driving electrode; Wherein the matching network comprises a temperature compensating capacitor connected in parallel with the piezoelectric element, the temperature compensating capacitor being for counteracting temperature-induced changes to the dielectric constant of the piezoelectric element such that the electrical natural frequency of the transducer is substantially constant over a range of temperatures.

Abstract: The present invention relates to a pharmaceutical aqueous formulation comprising 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea, or a pharmaceutically acceptable salt thereof, that is a clear solution. Such a formulation is particularly suitable for intravenous or parenteral administration to a patient.

Abstract: A system includes a combustor assembly which receives a fuel-oxidant mixture. The system includes a control valve which controls a fuel flow into the combustor assembly. The system includes one or more sensors which measure one or more properties. The system includes a controller communicatively coupled to the one or more sensors and the control valve. The controller receives data from the one or more sensors indicative of operating conditions of the combustor assembly. The controller determines a predicted fuel flow for a first fuel line of a plurality of fuel lines based in part on the data received from the one or more sensors. The controller calculates a difference between a commanded fuel flow and the predicted fuel flow. The controller adjusts an operation of the control valve associated with a gas turbine engine when the difference is greater than a threshold.

Abstract: A premix pilot nozzle is disclosed herein. The premix pilot nozzle includes a nozzle body. The nozzle body includes a forward wall, an aft wall, an outer band that extends between the forward wall and the aft wall and a tip portion that extends axially downstream from the aft wall. The nozzle body further defines a fuel inlet plenum that extends coaxially within the nozzle body, a fuel distribution plenum that is defined within the nozzle body radially outwardly from and in fluid communication with the fuel inlet plenum, a plurality of premix passages that extend helically around the fuel inlet plenum within the fuel distribution plenum and a plurality of air passages annularly arranged around the plurality of premix passages. One or more premix passages of the plurality of premix passages are in fluid communication with the fuel distribution plenum.