Abstract: A pressure relief valve (PRV) assembly may include a housing having an opening therein, an interior cavity, a passageway extending between the opening and the interior cavity, and a flange extending within the passageway adjacent the opening. The PRV assembly may also include a first stage valve carried within the interior cavity, and a second stage valve fluidly coupled in series with the first stage valve. The second stage valve may include an enlarged head carried within the opening and a shaft extending from the enlarged head through the passageway to the interior cavity. The shaft may have a proximal end coupled to the enlarged head and an opposing enlarged distal end adjacent the interior cavity. A biasing member may be between the enlarged distal end and the flange. The biasing member may be configured to bias the first and second stage valves to a closed position.

Abstract: The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.

Abstract: Web-based opinion survey method, apparatus, and computer-readable media operable to cause propositional function responses to be provided to a survey server from a client device. The propositional functions are P(x), where P and x are the predicate and subject. Each P(x) is evaluated in the client device for subjects, each with a different x. Preferably, the client device displays the subjects within a Web Single Page Application (SPA) running on the client device. Preferably, the SPA displays a nonnumerical scale, the granularity of which is directly proportional to the number of pixels spanned by the scale. For each P(x), the client device displays labeled markers along the scale, to provide an indication of a level of agreement with the expressed P(x). For each P(x) subject, the client expresses an opinion on a position on the scale, whereby a pixel position corresponds to a rating for the selected subject.

Abstract: An article of footwear including a sole having a forefoot portion, a midfoot portion and a heel portion and a support member including a first part and a second part, where the first part extends at least partially into the forefoot portion, and the second part extends from the first part and at least partially into a portion of the sole that is in or between the midfoot portion and the heel portion, the first part including a lateral support member and a medial support member that form a continuous loop defining an opening, an outer edge of the lateral support member and the medial support member combining to form an outermost edge having a continuous convex curvature, where the support member has a front end portion and a rear end portion, and the front end portion or the rear end portion has a curve extending in a vertical direction.

Abstract: An article of footwear is provided and includes a sole having a forefoot portion, a midfoot portion and a heel portion and a support member including a first part and a second part. The first part of the support member extends at least partially into the forefoot portion, and the second part of the support member extends from the first part and at least partially into a portion of the sole that is in or between the midfoot portion and the heel portion, where the first part forms a loop defining an opening.

Abstract: An article of footwear is provided and includes a sole having a forefoot portion, a midfoot portion and a heel portion and a support member including a first part and a second part. The first part of the support member extends at least partially into the forefoot portion, and the second part of the support member extends from the first part and at least partially into a portion of the sole that is in or between the midfoot portion and the heel portion, where the first part forms a loop defining an opening.

Abstract: An article of footwear is provided and includes a sole having a forefoot portion, a heel portion, a medial side and a lateral side. A first plate member is positioned on the medial side of the sole, where the first plate member has a first length, and a second plate member is positioned on the lateral side of the sole, where the second plate member has a second length. The first length of the first plate member is greater than or equal to the second length of the second plate member.

Abstract: The present invention provides a method for generation of multi-domain proteins, more particular antibodies, with an improved native state colloidal stability.

Abstract: The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.

Abstract: The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.

Abstract: Method and apparatus for attaching an electrical component to a printed circuit board. The apparatus includes a circuit board, an elastomeric connector, a rotary electrical component having a connector housing for holding the elastomeric connector, and one or more fasteners for securing the electrical component to the circuit board with sufficient force to compress the elastomeric connector and thereby ensure electrical contact between the electrical component and the printed circuit board.

Abstract: A sealed cabled assembly includes a cable and a cable moisture seal assembly. The cable includes a cable subcore, a metal shield layer surrounding the cable subcore, and a jacket surrounding the metal shield layer. The cable subcore includes an electrical conductor surrounded by an electrical insulation layer. The cable moisture seal assembly includes a sealant, a electrically conductive jumper member, and an outer sleeve. The cable includes a sealing region section extending from a first axial end to a second axial end, and in which a section of the jacket and a section of the metal shield layer are removed to expose a section of the cable subcore. The insulation layer and the conductor extend through the sealing region section. First and second sections of the jacket extend away from the sealing region section in first and second opposed directions, respectively.