Patents by Inventor James Heads

James Heads has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MULTI-DOMAIN PROTEINS WITH INCREASED NATIVE STATE COLLOIDAL STABILITY
    Publication number: 20250266122
    Abstract: The present invention provides a method for generation of multi-domain proteins, more particular antibodies, with an improved native state colloidal stability. The present disclosure provides a method of producing an IgG1 or IgG4 antibody with an improved colloidal stability comprising, in embodiments: calculating for each domain of said IgG1 or IgG4 antibody the total net charge at a given pH; introducing one or more modifications to the amino acid residues of the constant region of said IgG1 or IgG4 antibody to minimize the charge sign difference between the domains, wherein said one or more modification is, or each are, a substitution of a charged amino acid by a polar (non-charged) amino acid; and producing the modified multi-domain protein with improved colloidal stability at the given pH.
    Type: Application
    Filed: May 9, 2025
    Publication date: August 21, 2025
    Inventors: Ralph ADAMS, James HEADS, Sebastian KELM, Alastair David Griffiths LAWSON
  • Multi-domain proteins with increased native state colloidal stability
    Patent number: 12327614
    Abstract: The present invention provides a method for generation of multi-domain proteins, more particular antibodies, with an improved native state colloidal stability. The present disclosure provides a method of producing an IgG1 or IgG4 antibody with an improved colloidal stability comprising, in embodiments: calculating for each domain of said IgG1 or IgG4 antibody the total net charge at a given pH; introducing one or more modifications to the amino acid residues of the constant region of said IgG1 or IgG4 antibody to minimize the charge sign difference between the domains, wherein said one or more modification is, or each are, a substitution of a charged amino acid by a polar (non-charged) amino acid; and producing the modified multi-domain protein with improved colloidal stability at the given pH.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: June 10, 2025
    Assignee: UCB BIOPHARMA SRL
    Inventors: Ralph Adams, James Heads, Sebastian Kelm, Alastair David Griffiths Lawson
  • Antibodies of the class IGG4
    Patent number: 12091450
    Abstract: The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: September 17, 2024
    Assignee: UCB BIOPHARMA SRL
    Inventors: David Paul Humphreys, Ralph Adams, James Heads, Shirley Jane Peters
  • MULTI-DOMAIN PROTEINS WITH INCREASED NATIVE STATE COLLOIDAL STABILITY
    Publication number: 20210166780
    Abstract: The present invention provides a method for generation of multi-domain proteins, more particular antibodies, with an improved native state colloidal stability.
    Type: Application
    Filed: June 5, 2019
    Publication date: June 3, 2021
    Inventors: Ralph ADAMS, James HEADS, Sebastian KELM, Alastair David Griffiths LAWSON
  • Antibodies of the Class IGG4
    Publication number: 20200157204
    Abstract: The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.
    Type: Application
    Filed: December 17, 2019
    Publication date: May 21, 2020
    Inventors: David Paul Humphreys, Ralph Adams, James Heads, Shirley Jane Peters
  • Antibodies of the class IGG4
    Patent number: 10562966
    Abstract: The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: February 18, 2020
    Assignee: UCB BIOPHARMA SPRL
    Inventors: David Paul Humphreys, Shirley Jane Peters, Ralph Adams, James Heads
  • Antibodies of the Class IGG4
    Publication number: 20130323236
    Abstract: The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.
    Type: Application
    Filed: August 19, 2011
    Publication date: December 5, 2013
    Applicant: UCB PHARMA S.A.
    Inventors: David Paul Humphreys, Shirley Jane Peters, Ralph Adams, James Heads