Abstract: The present invention provides an electronic data document (EDD) and related system and method for use in a computerized clinical trial verification system. In an exemplary embodiment, the EDD is authenticated by the creator and validated by the receiver, and comprises an image of a source document (SD) that comprises a masked record of at least one interaction between a clinical trial investigator and a patient enrolled in a clinical trial, at least one revealed portion of the SD that includes evidence relevant to at least one question in a clinical trial questionnaire, and at least one annotation connecting the revealed portion to the at least one question. The present invention provides a computerized system and method for allowing a clinical trial investigator to answer questions from a clinical trial questionnaire pertinent to a clinical trial of a medical treatment using encrypted and partially masked electronic documents comprising images of original patient records.

Abstract: The present invention provides an electronic data document (EDD) and related system and method for use in a computerized clinical trial verification system. In an exemplary embodiment, the EDD is authenticated by the creator and validated by the receiver, and comprises an image of a source document (SD) that comprises a masked record of at least one interaction between a clinical trial investigator and a patient enrolled in a clinical trial, at least one revealed portion of the SD that includes evidence relevant to at least one question in a clinical trial questionnaire, and at least one annotation connecting the revealed portion to the at least one question. The present invention provides a computerized system and method for allowing a clinical trial investigator to answer questions from a clinical trial questionnaire pertinent to a clinical trial of a medical treatment using encrypted and partially masked electronic documents comprising images of original patient records.

Abstract: Systems and techniques for self service delivery of content stored on removable media. A self service terminal stores a plurality of titles in a repository, and copies of titles are stored to removable media devices maintained in the self service terminal. In response to a user selection of an available title made during a transaction, a removable media device storing a copy of the selected title is delivered to the user. Anticipated demand is estimated and titles are stored to removable devices as needed to maintain an inventory to meet the estimated demand, including overwriting existing titles already stored on removable media, and overwriting returned media as needed.

Abstract: A device may identify a plurality of sources for outputs that the device is configured to provide. The plurality of sources may include at least one of a particular application in the device, an operating system of the device, a particular area within a display of the device, or a particular graphical user interface object. The device may also assign a set of distinct voices to respective sources of the plurality of sources. The device may also receive a request for speech output. The device may also select a particular source that is associated with the requested speech output. The device may also generate speech having particular voice characteristics of a particular voice assigned to the particular source.

Abstract: This invention relates to the biosynthetic production of macrocyclic molecules from linear precursor peptides that contain highly truncated C terminal recognition sequences of 10 or fewer residues using prolyl oligopeptidase (POP) macrocyclases. This may be useful for example in the biosynthetic production of macrocyclic molecules. Methods and kits for the production of macrocyclic molecules, as well as libraries and methods of screening, are provided.

Abstract: The invention relates to triazole compounds of formula I and I? or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions and kits thereof in the treatment of various demyelinating and neurodegenerative diseases, including multiple sclerosis.

Abstract: A device may identify a plurality of sources for outputs that the device is configured to provide. The plurality of sources may include at least one of a particular application in the device, an operating system of the device, a particular area within a display of the device, or a particular graphical user interface object. The device may also assign a set of distinct voices to respective sources of the plurality of sources. The device may also receive a request for speech output. The device may also select a particular source that is associated with the requested speech output. The device may also generate speech having particular voice characteristics of a particular voice assigned to the particular source.

Abstract: A heat exchanger that comprises a plurality of small channels that are arranged around a cross-sectional perimeter such that the sides of the small channels are touching to create bigger channels running parallel to the small channels. To this end, embodiments of the present invention have a heat exchanger matrix where the structure of the large channels is entirely comprised by the structure of the smaller channels resulting in a more compact, more efficient heat exchanger.

Abstract: The present invention provides an electronic data document (EDD) and related system and method for use in a computerized clinical trial verification system. In an exemplary embodiment, the EDD is authenticated by the creator and validated by the receiver, and comprises an image of a source document (SD) that comprises a masked record of at least one interaction between a clinical trial investigator and a patient enrolled in a clinical trial, at least one revealed portion of the SD that includes evidence relevant to at least one question in a clinical trial questionnaire, and at least one annotation connecting the revealed portion to the at least one question. The present invention provides a computerized system and method for allowing a clinical trial investigator to answer questions from a clinical trial questionnaire pertinent to a clinical trial of a medical treatment using encrypted and partially masked electronic documents comprising images of original patient records.

Abstract: This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: This invention provides heterocyclic compounds that bind to E3 Ubiquitin Ligase (typically through cereblon) (“Degrons”), which can be used as is or linked to a Targeting Ligand for a selected Target Protein for therapeutic purposes and methods of use and compositions thereof as well as methods for their preparation.

Abstract: This invention provides Degronimers that have E3 Ubiquitin Ligase targeting moieties (Degrons) that can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation. The invention also provides Degrons that can be used to treat disorders mediated by cereblon or an Ikaros family protein, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: Some umbrellas include a support assembly, canopy assembly, and a toroidal air bladder. The support assembly includes a pump and a handle. The canopy assembly includes a plurality of support ribs attached to the handle, and a sheet attached to each of the support ribs. The toroidal air bladder is coupled to the air pump, and the air bladder disposed about the handle and engages the support ribs.

Abstract: A heat exchanger assembly that in a preferred embodiment comprises: an inlet duct lower wall interfacing with a bypass duct; an outlet duct lower wall interfacing with a bypass duct; a heat exchanger coupled between the inlet duct lower wall and the outlet duct lower wall wherein the heat exchanger is at a compound angle with respect to an inlet duct air flow direction; and a fairing coupled to the top of the heat exchanger wherein the fairing forms the inlet duct upper wall and the outlet duct upper wall.

Abstract: A fuel nozzle apparatus includes: an outer body having an exterior surface and a plurality of openings in the exterior surface. An inner body is disposed inside the outer body, cooperating with the outer body to define an annular space. A main injection ring is disposed in the annular space and includes an array of fuel posts extending outward therefrom, each fuel post including a perimeter wall defining a lateral surface and a recessed floor. Each fuel post is aligned with one of the openings and separated from the opening by a perimeter gap defined between the opening and the lateral surface. A main fuel gallery extends within the main injection ring. The main injection ring includes plurality of main fuel orifices, each main fuel orifice communicating with the main fuel gallery and extending through one of the fuel posts.

Abstract: The exercise ball chair stabilizes an exercise ball so that it can be used as a comfortable chair. While seated in the exercise ball chair, a user may perform seated-workout exercises. The exercise ball chair comprises a left support, a right support, and a ball retainer. The ball retainer pivots between a ball retention position and a ball release position. An exercise ball is placed in the chair such that the left support, the right support, and the ball retainer, in the ball retention position, capture the exercise ball and prevent it from rolling. A user may then sit on the exercise ball. A left adjustment knob and a right adjustment knob allow the ball retainer to be locked to prevent it from pivoting. With the adjustment knobs loosened, the ball retainer may be pivoted to the ball release position and the exercise ball may be removed.

Abstract: A USB-Coaxial Cable connector that includes: a first end, where the first end includes USB connector; and a second end, where the second end includes a coaxial cable connector. In one embodiment, the USB-Coaxial Cable connector includes a female USB connector at the first end and a male coaxial connector at the second end. In a second embodiment, the USB-Coaxial Cable connector includes a male USB connector and the second end includes a female coaxial connector.

Abstract: A fuel nozzle includes an outer body extending parallel to a centerline axis, having a generally cylindrical exterior surface, forward and aft ends, and a plurality of openings through the exterior surface. The fuel nozzle further includes an inner body inside the outer body, cooperating with the outer body to define an annular space, and a main injection ring inside the annular space, the main injection ring including fuel posts extending therefrom. Each fuel post is aligned with one of the openings and separated from the opening by a perimeter gap which communicates with the annular space. There is a circumferential main fuel gallery in the main injection ring, and a plurality of main fuel orifices, wherein each orifice communicates with the main fuel gallery and extends through one of the fuel posts.

Abstract: A braille cell and associated braille pin support and pin actuation assemblies are disclosed. The braille cell can include a frame, braille pins movable up and down between raised and lowered positions, and a pin actuation assembly to individually move the pins. The braille cell can include support arms, each of which having a base end connected to the frame and a pin end connected to and following a motion of a respective pin between its raised and lowered positions. The pin actuation assembly can include pin actuation units, each having a motor with a rotatable motor shaft and multiple cams mounted on the shaft, each for selectively actuating a respective pin. Each pin actuation unit can also include an angular position sensing system for monitoring, for example magnetically, a passage of the shaft through a reference angular position, and deriving information about a current angular position of the shaft.

Abstract: An enzyme responsive shape memory polymer formed from a glassy, cross-linked shape memory polymer that incorporates ester bonds that are responsive to the present of an enzyme. PCL-based polyurethanes (featuring simple alternation of PCL diol and lysine-based diisocyanate) are degradable by Amano lipase PS. A non-degradable thermoplastic elastomer may be dual electrospun with a polycaprolactone based TPU with the fixing phase compressed so that the composite is ready for enzymatically triggered contraction. Alternatively, the elastomer may be a PCL copolymer-based polyurethane amorphous elastomer that is both degradable and elastomeric and put into compression so that upon enzymatic degradation of the elastomeric phase the scaffold expands.