Abstract: A piece of heavy construction or forestry equipment includes an internal combustion engine configured to generate power from combustion of fuel, a winch coupled to the internal combustion engine such that power generated by the internal combustion engine is transmitted to the winch by a non-mechanical connection, a first electronic control unit, wherein the first electronic control unit is configured to control operation of components of the piece of heavy construction equipment other than the winch, and a second electronic control unit, wherein the second electronic control unit is independent of the first electronic control unit and configured to control operation of the winch.

Abstract: Novel benzofurans, benzothiophenes and indoles useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions.

Abstract: Novel quinazolinones useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions.

Abstract: Novel quinazolinones useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions.

Abstract: Novel benzofurans, benzothiophenes and indoles useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions.

Abstract: Novel benzofurans, benzothiophenes and indoles useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions.

Abstract: Novel quinazolinones useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions.

Abstract: The invention relates to heterocyclic substituted carbonyl derivatives that display selective binding to dopamine D3 receptors. In another aspect, the invention relates to a method for treating central nervous system disorders associated with the dopamine D3 receptor activity in a patient in need of such treatment comprising administering to the subject a therapeutically effective amount of said compounds for alleviation of such disorder. The central nervous system disorders that may be treated with these compounds include Psychotic Disorders, Substance Dependence, Substance Abuse, Dyskinetic Disorders (e.g. Parkinson's Disease, Parkinsonism, Neuroleptic-Induced Tardive Dyskinesia, Gilles de la Tourette Syndrome and Huntington's Disease), Dementia, Anxiety Disorders, Sleep Disorders, Circadian Rhythm Disorders and Mood Disorders.

Abstract: The invention relates to heterocyclic substituted carbonyl derivatives that display selective binding to dopamine D3 receptors. In another aspect, the invention relates to a method for treating central nervous system disorders associated with the dopamine D3 receptor activity in a patient in need of such treatment comprising administering to the subject a therapeutically effective amount of said compounds for alleviation of such disorder. The central nervous system disorders that may be treated with these compounds include Psychotic Disorders, Substance Dependence, Substance Abuse, Dyskinetic Disorders (e.g. Parkinson's Disease, Parkinsonism, Neuroleptic-Induced Tardive Dyskinesia, Gilles de la Tourette Syndrome and Huntington's Disease), Dementia, Anxiety Disorders, Sleep Disorders, Circadian Rhythm Disorders and Mood Disorders.

Abstract: A combiner for optical beams includes a substrate overlaid by a multi-layer dielectric film stack. The substrate is a clear material and the dielectric film stack is a series of alternating layer of high and low refractive index. This gives the combiner relatively high reflectivity across UV wavelengths and relatively high transmissivity in the visible and longer wavelengths and allows visible light to pass through the combiner while UV light is reflected. At the same time dielectric film stack has minimal absorption and scatter. This means that the intensity of visible light maintains at least 90% of its intensity as it passes through combiner and UV light retains at least 90% of its intensity as it is reflected by combiner.

Abstract: The invention relates to heterocyclic substituted carbonyl derivatives that display selective binding to dopamine D3 receptors. In another aspect, the invention relates is to a method for treating central nervous system disorders associated with the dopamine D3 receptor activity in a patient in need of such treatment comprising administering to the subject a therapeutically effective amount of said compounds for alleviation of such disorder. The central nervous system disorders that may be treated with these compounds include Psychotic Disorders, Substance Dependence, Substance Abuse, Dyskinetic Disorders (e.g. Parkinson's Disease, Parkinsonism, Neuroleptic-Induced Tardive Dyskinesia, Gilles de la Tourette Syndrome and Huntington's Disease), Dementia, Anxiety Disorders, Sleep Disorders, Circadian Rhythm Disorders and Mood Disorders.

Abstract: The invention relates to heterocyclic substituted amide derivatives that display selective binding to dopamine D3 receptors. In another aspect, the invention relates to a method for treating central nervous system disorders associated with the dopamine D3 receptor activity in a patient in need of such treatment comprising administering to the subject a therapeutically effective amount of said compounds for alleviation of such disorder. The central nervous system disorders that may be treated with these compounds include Psychotic Disorders, Substance Dependence, Substance Abuse, Dyskinetic Disorders (e.g. Parkinson's Disease, Parkinsonism, Neuroleptic-Induced Tardive Dyskinesia, Gilles de la Tourette Syndrome and Huntington's Disease), Dementia, Anxiety Disorders, Sleep Disorders, Circadian Rhythm Disorders and Mood Disorders.

Abstract: A first method for fabricating low-noise optical components for use in optical metrology systems includes shaping a glass substrate to obtain a desire shape and then coating the glass substrate with a reflective coating. A second method includes shaping a glass master die to a desired shape and then using the glass master to form a glass substrate to the desire shape. A third method includes diamond turning a substrate to a desired shape and then polishing the substrate to meet two surface conditions which in turn ensures that the scattered light is minimized and the metrology instruments performance is greatly increased. These conditions relate to a measurement of encircled energy compared to an ideal diffraction limited component of the same focal length and diameter.

Abstract: A carpet constructed from a biodegradable nonwoven face layer and a backing layer that is biodegradable and/or recyclable. The face layer comprises a needle-punched nonwoven web formed from a blend of different fiber types each of which is biodegradable, the blend comprising face fibers having a relatively high decomposition temperature and thermally activatable binder fibers having a thermal activation temperature lower than the decomposition temperature of the face fibers. The binder fibers bind to one another and to the face fibers. The face fibers can comprise one or more types of fibers that are biodegradable. Suitable fiber types include but are not limited to wool, hemp, cotton, polylactic acid, jute, flax, kanaf, sisal, rayon, and silk. The binder fibers in some embodiments of the invention comprise low-melt polylactic acid.

Abstract: A device includes a housing that has a plurality of monolithically formed walls, wherein selected walls are provided with inlet and outlet ports respectively. The housing includes a coupling in fluid communication with the inlet and outlet ports, a mechanism for detecting a fluctuation in water pressure, and a mechanism for selectively prohibiting water flow. The prohibiting mechanism cooperates with the detecting mechanism. The housing also includes a mechanism for providing an audible notification when the water supply is toggled between interrupted and reinstated modes and a mechanism for manually controlling the prohibiting mechanism. The manually controlling mechanism is electrically coupled to the prohibiting mechanism. An internal power supply source supplies power to the detecting mechanism, the prohibiting mechanism, and the manually controlling mechanism. A diode is attached to the housing and is illuminable when the power supply source reaches a minimum threshold level.

Abstract: A combiner for optical beams includes a substrate overlaid by a multi-layer dielectric film stack. The substrate is a clear material and the dielectric film stack is a series of alternating layer of high and low refractive index. This gives the combiner relatively high reflectivity across UV wavelengths and relatively high transmissivity in the visible and longer wavelengths and allows visible light to pass through the combiner while UV light is reflected. At the same time dielectric film stack has minimal absorption and scatter. This means that the intensity of visible light maintains at least 90% of its intensity as it passes through combiner and UV light retains at least 90% of its intensity as it is reflected by combiner.

Abstract: A combiner for optical beams includes a substrate overlaid by a multi-layer dielectric film stack. The substrate is a clear material and the dielectric film stack is a series of alternating layer of high and low refractive index. This gives the combiner relatively high reflectivity across UV wavelengths and relatively high transmissivity in the visible and longer wavelengths and allows visible light to pass through the combiner while UV light is reflected. At the same time dielectric film stack has minimal absorption and scatter. This means that the intensity of visible light maintains at least 90% of its intensity as it passes through combiner and UV light retains at least 90% of its intensity as it is reflected by combiner.

Abstract: A process for making a high-strength spun yarn begins by feeding one or more tows of substantially uncrimped continuous filaments of high-modulus material having a tensile modulus exceeding about 20×106 psi through a high-speed stretch-breaking apparatus operating at low total draft ratio (preferably about 2.0) to break the filaments into high-modulus staple fibers having an average length in the range of about 5 to 6 inches. The tows advantageously are heavy, for example, having a denier of about 25,000 to about 500,000. Following the stretch-breaking step, the staple fibers are collected in sliver cans, and the staple fibers are advanced from the sliver cans to a spinning machine, where the fibers are spun into yarn. An important aspect of the invention is that no intermediate processes are performed between the stretch-breaking and spinning processes, which minimizes disruption of the alignment of and damage to the staple fibers.

Abstract: An optical filter for the selective attenuation of specific wavelengths of light includes at least one spectrally dispersive element, such as a diffraction grating or prism, in combination with an optical filter. A dispersive element separates broadband light into a constituent wavelength spread in angle space. An optical filter, or filter array, can block and/or attenuate specific wavelengths or wavelength ranges of interest while the light is angularly dispersed. A second dispersive element can recombine this filtered, separated wavelength fan of light into a coaxial broadband beam having a smoother intensity profile than the unfiltered beam.

Abstract: A dynamic workload management system enables system administrators to easily identify installed applications and to assign them to affinity groupings in order of importance to the enterprise and to enable the system administrators to save and restore multiple configurations. The workload configuration is continually updated based on the hardware utilization measurements of the application groups that make up a workload configuration. The software interface of the system of the invention permits the system to dynamically add and remove processors to and from affinity masks that are automatically set up. This feature of the invention allows the application groups to consume CPU resources according to their priority.