Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Abstract: In embodiments, a first resource is produced for a first dataset having a time indicator, by applying a first digital rule. A first notification can be caused to be transmitted about an aspect of the first resource to a remote device. A second dataset can be stored, which has values derived from the first dataset, and encodes a parameter of the first resource. A second digital rule may be stored to replace the first digital rule, at an updating time (Tupd). The second digital rule may have an effective time (Teff) prior to the actual updating time Tupd. A second resource may be produced by applying the second digital rule. A second notification can be caused to be transmitted about an aspect of the second resource to a remote device.

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Abstract: Disclosed herein are implementations of a method and apparatus for stroke self-detection. The method and apparatus may include a mobile platform for stroke detection. The method may include receiving sensor data. The method may include comparing the sensor data with a baseline test result to determine a test score. The method may include determining a passing test result based on a threshold. The method may include transmitting the results or an alert to one or more of an emergency contact, emergency medical services, a physician, or a telemedicine provider.

Abstract: Described herein are bifunctional compounds, as well as pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, or tautomers thereof, that function to recruit certain deubiquitinases to a target protein for modulation (e.g., stabilization) of the target protein, as well as methods of use thereof.

Abstract: In embodiments, a computer system produces a first resource for a first dataset having a time indicator, by applying a first digital rule. A first notification can be caused to be transmitted about an aspect of the first resource to a remote device. A second dataset can be stored, which has values derived from the first dataset, and encodes a parameter of the first resource. A second digital rule may be stored to replace the first digital rule, at an updating time (Tupd). The second digital rule may have an effective time (Teff) prior to the actual updating time Tupd. A second resource may be produced by applying the second digital rule. A second notification can be caused to be transmitted about an aspect of the second resource to a remote device.

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Abstract: A method includes attaching a gas capture device to a bypass system adjacent to a gas meter. The method also includes rotating an internal cartridge near the gas meter to a bypass mode. The rotation of the internal cartridge enables gas to be diverted through a bypass system and away from the gas meter into an outlet. Remaining gas is captured from the gas meter to prevent the gas from releasing externally. The gas meter is removed from its original position. The internal cartridge is rotated from the bypass mode to a purge mode.

Abstract: A method includes attaching a gas capture device to a bypass system adjacent to a gas meter. The method also includes rotating an internal cartridge near the gas meter to a bypass mode. The rotation of the internal cartridge enables gas to be diverted through a bypass system and away from the gas meter into an outlet. Remaining gas is captured from the gas meter to prevent the gas from releasing externally. The gas meter is removed from its original position. The internal cartridge is rotated from the bypass mode to a purge mode.

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Abstract: Disclosed herein are implementations of a method and apparatus for stroke self-detection. The method and apparatus may include a mobile platform for stroke detection. The method may include receiving sensor data. The method may include comparing the sensor data with a baseline test result to determine a test score. The method may include determining a passing test result based on a threshold. The method may include transmitting the results or an alert to one or more of an emergency contact, emergency medical services, a physician, or a telemedicine provider.

Abstract: Disclosed herein are implementations of a method and apparatus for stroke self-detection. The method and apparatus may include a mobile platform for stroke detection. The method may include receiving sensor data. The method may include comparing the sensor data with a baseline test result to determine a test score. The method may include determining a passing test result based on a threshold. The method may include transmitting the results or an alert to one or more of an emergency contact, emergency medical services, a physician, or a telemedicine provider.

Abstract: A system may learn what parameters are required for an item in order to compute tax for the item based on preliminary data regarding the item and/or the transaction. The system may determine a classification code based on such preliminary data and use that classification code to search or query a database storing information indicative of parameters required to compute tax for items having such a classification code. The system may map the received preliminary data into the learned required parameters and determine whether there are any required parameters for which there has not been any preliminary data mapped into them. The system may prompt the customer (e.g., seller of the item) or other user for data values of such missing required parameters or otherwise obtain data values of such parameters in order to compute the tax for the item.

Abstract: A system may learn what parameters are required for an item in order to compute tax for the item based on preliminary data regarding the item and/or the transaction. The system may determine a classification code based on such preliminary data and use that classification code to search or query a database storing information indicative of parameters required to compute tax for items having such a classification code. The system may map the received preliminary data into the learned required parameters and determine whether there are any required parameters for which there has not been any preliminary data mapped into them. The system may prompt the customer (e.g., seller of the item) or other user for data values of such missing required parameters or otherwise obtain data values of such parameters in order to compute the tax for the item.

Abstract: Disclosed herein are implementations of a method and apparatus for stroke self-detection. The method and apparatus may include a mobile platform for stroke detection. The method may include receiving sensor data. The method may include comparing the sensor data with a baseline test result to determine a test score. The method may include determining a passing test result based on a threshold. The method may include transmitting the results or an alert to one or more of an emergency contact, emergency medical services, a physician, or a telemedicine provider.

Abstract: A barrier for concealing text of a transactional card has a layer of adhesive and a layer of foam. The barrier has a primary side connected to a secondary side at a hinge point. The hinge point has a plurality of perforations. The primary side of the barrier is configured to overlay at least a portion of text on the front face of a transactional card. The secondary side of the barrier is configured to overlay at least a portion of text located on the rear of a transactional card. The barrier has a tab protruding from an outer perimeter edge of the barrier and at least one recess configured to be oriented to overlay the embossed text of a transactional card. The barrier can have an opening configured to make at least a portion of the text of a transactional card visible through the opening to a user.

Abstract: A chocolate composition and a method for manufacturing the chocolate composition include a solid material, e.g., nutritive carbohydrate sweetener that has a particle size from about 50 to about 1000 nanometers. The solid material may comprise a sugar, such as but not limited to, sucrose. By including within the chocolate composition the solid material that has the particle size from about 50 to about 1000 nanometers, the chocolate composition has enhanced temperature resistance properties.

Abstract: A system is provided for operating a railway network including a first railway vehicle during a trip along track segments. The system includes a first element for determining travel parameters of the first railway vehicle, a second element for determining travel parameters of a second railway vehicle relative to the track segments to be traversed by the first vehicle during the trip, a processor for receiving information from the first and the second elements and for determining a relationship between occupation of a track segment by the second vehicle and later occupation of the same track segment by the first vehicle and an algorithm embodied within the processor having access to the information to create a trip plan that determines a speed trajectory for the first vehicle. The speed trajectory is responsive to the relationship and further in accordance with one or more operational criteria for the first vehicle.

Abstract: One embodiment of the invention includes a system for operating a railway network comprising a first railway vehicle (400) during a trip along track segments (401/412/420).

Abstract: A chocolate composition and a method for manufacturing the chocolate composition include a solid material, e.g., nutritive carbohydrate sweetener that has a particle size from about 50 to about 1000 nanometers. The solid material may comprise a sugar, such as but not limited to, sucrose. By including within the chocolate composition the solid material that has the particle size from about 50 to about 1000 nanometers, the chocolate composition has enhanced temperature resistance properties.