Patents by Inventor James Hickman

James Hickman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230017982
    Abstract: An example print material replenishment device includes a container to contain print material, a dispensing end to engage a fill port of a printing device, the dispensing end including an opening that is offset from a center axis of the container, and a rotatable cover coupled to the dispensing end, the rotatable cover to expose the opening of the dispensing end based on a rotation of the print material replenishment device.
    Type: Application
    Filed: September 28, 2022
    Publication date: January 19, 2023
    Inventors: Andrew P. CHICK, Kenneth K. SMITH, Matthew James STOREY, Pratik SHAH, Luke KIM, Sean Daniel FITZGERALD, Mathew LAVIGNE, Jeffrey H. LUKE, Jiwon MOON, Minchul LEE, Corbett Benjamin SCHOENFELT, Bennett Alexander NADEAU, Zackary Thomas HICKMAN, Jefferson Blake WEST, Muriel Hale SHIELDS, An TRAN
  • Patent number: 11554373
    Abstract: A pumpless microfluidic system is disclosed that can be used to mimic the interaction of organ systems with the immune system. Also disclosed is a method for mimicking an immune system, comprising culturing a plurality of organ cells and at least one population of immune cells in the disclosed pumpless microfluidic system under physiological conditions. The method can further comprise activating an immune reaction in the pumpless microfluidic system, continuing the culture for a defined period, collecting a sample of culture medium from the system, and assaying the sample for one or more indicators of an immune response.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: January 17, 2023
    Assignees: University of Central Florida Research Foundation, Inc., Hesperos, Inc.
    Inventors: James Hickman, Alisha Colon, Christopher McAleer, Trevor Sasserath, John Rumsey, Daniel Elbrecht
  • Patent number: 11491797
    Abstract: In some examples, a print materials container can include a dispense mechanism to dispense print materials directly to an in-situ reservoir of a printing device, a lock feature to engage a fill port during connection of the dispense mechanism to the fill port, and a valve integrated with the dispense mechanism for connecting the dispense mechanism to the fill port of the reservoir and comprising an output opening offset from a center axis of a tip of the dispense mechanism. The valve can open responsive to rotation of the valve opening with respect to the lock feature such that opposite openings align.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: November 8, 2022
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Andrew P. Chick, Kenneth K. Smith, Matthew James Storey, Pratik Shah, Luke Kim, Sean Daniel Fitzgerald, Mathew Lavigne, Jeffrey H. Luke, Jiwon Moon, Minchul Lee, Corbett Benjamin Schoenfelt, Bennett Alexander Nadeau, Zackary Thomas Hickman, Jefferson Blake West, Muriel Hale Shields, An Tran
  • Patent number: 11454921
    Abstract: Examples of a host device that includes an input recess are described. In some examples, the input recess includes a rotating port cover offset from a central axis of the input recess. In some examples, the input recess includes a plurality of contacts disposed on an interfacing surface of the input recess to interface with a print particle replenishment device when the rotating port cover is rotated. In some examples, the plurality of contacts interfaces with a control device to authenticate the print particle replenishment device.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: September 27, 2022
    Assignee: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
    Inventors: Ji-Won Moon, Min-Chul Lee, Kwangsung Park, Yuntae Kim, Jinwoo Noh, Matthew James Storey, Seungsup Lee, Zackary Thomas Hickman, Amy Moon Williams, An Tran, Bennett Alexander Nadeau
  • Patent number: 11443085
    Abstract: Disclosed herein are microfluidic systems with recirculation of fluid and computer-implemented methods of calculating conditions within the microfluidic systems. The microfluidic systems include a computing device and a microfluidic device having first and second reservoirs, at least one chamber, and a fluid path connecting the first reservoir, the chamber, and the second reservoir. The methods for calculating conditions include receiving a first reservoir fluid volume, a second reservoir fluid volume, a first concentration, and a second concentration. The methods further include receiving a time-dependent imposed pressure difference between the first reservoir and the second reservoir, then determining a hydraulic pressure difference and an effective pressure difference. The effective pressure difference is used to account for reactions occurring within the microfluidic device and to determine the value of the condition within the microfluidic device.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: September 13, 2022
    Assignee: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: James Hickman, Kazi Tasneem, Christopher Long
  • Patent number: 11022605
    Abstract: Disclosed herein are cell culture analog devices, systems and methods for applying stimuli to components containing different cell types and recording the cell responses before, during, and after a stimulus (for example, a drug, metabolite, toxin, or electrical stimulus) is introduced. Responses can be stored to a database and compared to previous results. By analyzing how each cell type responds to various stimulation parameters, for example, by using multivariate analyses, cell signaling pathway information can be determined or new pathways can be discovered. In some implementations, an individual component interfaces with a specific cell type. This facilitates readout of the cell response to the stimulation. Various components can also interface with each other, such that the behavior of one cell type can affect a cell type in another component. Once assembled, the system is plugged into readout electronics and a programmable electrical stimulator.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: June 1, 2021
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: James Hickman, Lee Kumanchik, Navaneetha Santhanam
  • Patent number: 10935541
    Abstract: Disclosed herein are devices comprising one or more cantilevers comprising one or more neuromuscular junctions formed by a co-culture of myotubes and motoneurons. Disclosed herein are methods of using the disclosed devices comprising one or more cantilevers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: March 2, 2021
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: James Hickman, Alexander Smith, Christopher Long, Kristen Pirozzi
  • Publication number: 20200400647
    Abstract: In an aspect, disclosed herein are physiological devices and systems, and components thereof, used to evaluate cardiac parameters and arrhythmogenic mechanisms. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: June 26, 2020
    Publication date: December 24, 2020
    Inventors: James HICKMAN, Maria Stancescu, Peter Molnar, Christopher Long, Christopher McAleer
  • Patent number: 10559173
    Abstract: A non-contact voltage detector for detecting and indicating voltage. The non-contact voltage detector includes a housing having a voltage detection probe and plurality of light sources. The housing further includes an integral power source that is rechargeable via an external power source coupled to a user input port. The power source provides electrical energy to the non-contact voltage detector that further includes a controller and control circuit that is operably connected to at least one light source. The controller and control circuit can detect electrical energy at the user input port, detect the charge state of the integral power source, charge the integral power source, and emit one or more charge state light indicators when the state of the integral power source changes. In addition, the light sources can indicate the presence of voltage at the probe and can be independently activated by one or more switches.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: February 11, 2020
    Inventor: James Hickman
  • Publication number: 20200001297
    Abstract: A pumpless microfluidic system is disclosed that can be used to mimic the interaction of organ systems with the immune system. Also disclosed is a method for mimicking an immune system, comprising culturing a plurality of organ cells and at least one population of immune cells in the disclosed pumpless microfluidic system under physiological conditions. The method can further comprise activating an immune reaction in the pumpless microfluidic system, continuing the culture for a defined period, collecting a sample of culture medium from the system, and assaying the sample for one or more indicators of an immune response.
    Type: Application
    Filed: December 29, 2017
    Publication date: January 2, 2020
    Inventors: James HICKMAN, Alisha COLON, Christopher MCALEER, Trevor SASSERATH, John RUMSEY, Daniel ELBRECHT
  • Publication number: 20190318054
    Abstract: Disclosed herein are microfluidic systems with recirculation of fluid and computer-implemented methods of calculating conditions within the microfluidic systems. The microfluidic systems include a computing device and a microfluidic device having first and second reservoirs, at least one chamber, and a fluid path connecting the first reservoir, the chamber, and the second reservoir. The methods for calculating conditions include receiving a first reservoir fluid volume, a second reservoir fluid volume, a first concentration, and a second concentration. The methods further include receiving a time-dependent imposed pressure difference between the first reservoir and the second reservoir, then determining a hydraulic pressure difference and an effective pressure difference. The effective pressure difference is used to account for reactions occurring within the microfluidic device and to determine the value of the condition within the microfluidic device.
    Type: Application
    Filed: April 11, 2019
    Publication date: October 17, 2019
    Inventors: James Hickman, Kazi Tasneem, Christopher Long
  • Publication number: 20190285616
    Abstract: Disclosed herein are cell culture analog devices, systems and methods for applying stimuli to components containing different cell types and recording the cell responses before, during, and after a stimulus (for example, a drug, metabolite, toxin, or electrical stimulus) is introduced. Responses can be stored to a database and compared to previous results. By analyzing how each cell type responds to various stimulation parameters, for example, by using multivariate analyses, cell signaling pathway information can be determined or new pathways can be discovered. In some implementations, an individual component interfaces with a specific cell type. This facilitates readout of the cell response to the stimulation. Various components can also interface with each other, such that the behavior of one cell type can affect a cell type in another component. Once assembled, the system is plugged into readout electronics and a programmable electrical stimulator.
    Type: Application
    Filed: August 16, 2017
    Publication date: September 19, 2019
    Inventors: James Hickman, Lee Kumanchik, Navaneetha Santhanam
  • Patent number: 10386360
    Abstract: The invention discloses a bio-MEMS transducer comprising a cultured myotube and a piezoelectric microcantilever having the myotube attached thereto along a lengthwise extent of said microcantilever. The transducer may include an input/output processor operably connected with said piezoelectric microcantilever to process electrical signals received therefrom and to send electrical signals thereto. The invention may operate as a biosensor wherein the attached myotube contracts on contact with a sensed agent, the myotube contraction deflecting the microcantilever to generate a piezoelectric signal therefrom. The invention may also be used as a biosensor for quantitating physiologic response to an agent by measuring deflection of the cantilever caused by myotube contraction elicited by contact with the agent; and correlating the measurement to effectiveness of the sensed agent in causing a myotube physiologic response.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: August 20, 2019
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventor: James Hickman
  • Patent number: 10266804
    Abstract: The invention provides a method of co-culturing mammalian muscle cells and mammalian motoneurons. The method comprises preparing one or more carriers coated with a covalently bonded monolayer of trimethoxysilylpropyl diethylenetriamine (DETA); suspending isolated fetal mammalian skeletal muscle cells in serum-free medium according to medium composition 1; suspending isolated fetal mammalian spinal motoneurons in serum-free medium according to medium composition 1; plating the suspended muscle cells onto the one or more carriers at a predetermined density and allowing the muscle cells to attach; plating the suspended motoneurons at a predetermined density onto the one or more carriers and allowing the motoneurons to attach; covering the one or more carriers with a mixture of medium composition 1 and medium composition 2; and incubating the carriers covered in the media mixture.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: April 23, 2019
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: James Hickman, Mainak Das
  • Patent number: 9952204
    Abstract: A method for forming neuromuscular junctions includes forming functional neuromuscular junctions between motoneurons and muscle cells by co-culturing one or more human motoneurons and one or more rat muscle cells in a substantially serum-free medium. A synthetic mammalian neuromuscular junction includes a human motoneuron functionally linked to a rat muscle cell in a substantially serum-free medium. An artificial substrate may be used to support the one or more neuromuscular junctions.
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: April 24, 2018
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: James Hickman, Xiufang Guo, Mercedes Gonzalez, Maria Stancescu
  • Publication number: 20180095073
    Abstract: The invention discloses a bio-MEMS transducer comprising a cultured myotube and a piezoelectric microcantilever having the myotube attached thereto along a lengthwise extent of said microcantilever. The transducer may include an input/output processor operably connected with said piezoelectric microcantilever to process electrical signals received therefrom and to send electrical signals thereto. The invention may operate as a biosensor wherein the attached myotube contracts on contact with a sensed agent, the myotube contraction deflecting the microcantilever to generate a piezoelectric signal therefrom. The invention may also be used as a biosensor for quantitating physiologic response to an agent by measuring deflection of the cantilever caused by myotube contraction elicited by contact with the agent; and correlating the measurement to effectiveness of the sensed agent in causing a myotube physiologic response.
    Type: Application
    Filed: May 15, 2017
    Publication date: April 5, 2018
    Inventor: James Hickman
  • Publication number: 20170313980
    Abstract: The invention provides a method of co-culturing mammalian muscle cells and mammalian motoneurons. The method comprises preparing one or more carriers coated with a covalently bonded monolayer of trimethoxysilylpropyl diethylenetriamine (DETA); suspending isolated fetal mammalian skeletal muscle cells in serum-free medium according to medium composition 1; suspending isolated fetal mammalian spinal motoneurons in serum-free medium according to medium composition 1; plating the suspended muscle cells onto the one or more carriers at a predetermined density and allowing the muscle cells to attach; plating the suspended motoneurons at a predetermined density onto the one or more carriers and allowing the motoneurons to attach; covering the one or more carriers with a mixture of medium composition 1 and medium composition 2; and incubating the carriers covered in the media mixture.
    Type: Application
    Filed: May 15, 2017
    Publication date: November 2, 2017
    Inventors: James Hickman, Mainak Das
  • Patent number: 9650606
    Abstract: The invention provides a method of co-culturing mammalian muscle cells and mammalian motoneurons. The method comprises preparing one or more carriers coated with a covalently bonded monolayer of trimethoxysilylpropyl diethylenetriamine (DETA); suspending isolated fetal mammalian skeletal muscle cells in serum-free medium according to medium composition 1; suspending isolated fetal mammalian spinal motoneurons in serum-free medium according to medium composition 1; plating the suspended muscle cells onto the one or more carriers at a predetermined density and allowing the muscle cells to attach; plating the suspended motoneurons at a predetermined density onto the one or more carriers and allowing the motoneurons to attach; covering the one or more carriers with a mixture of medium composition 1 and medium composition 2; and incubating the carriers covered in the media mixture.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: May 16, 2017
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: James Hickman, Mainak Das
  • Patent number: 9489474
    Abstract: The invention provides a model for generating predicted action potentials of an electrically active cell. The disclosed model includes three operatively coupled submodels. A first submodel contains Hodgkin-Huxley elements generating action potentials based on electrical equivalent circuits. A second submodel is based on reaction kinetics of cell metabolism and is operatively coupled with the first submodel. A third submodel is based on Boolean dynamics representing signaling and associated cellular processes and is operatively coupled with the first and second submodels. The invention includes storing a library of calculated action potentials and associated cellular parameters generated by the model, applying a stimulus to the electrically active cell in vitro so that the cell generates an action potential; and comparing the cell-generated action potential with those stored in the library, wherein a match is predictive of the cellular point of action of the applied stimulus according to the parameters stored.
    Type: Grant
    Filed: February 7, 2011
    Date of Patent: November 8, 2016
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: James Hickman, Peter Molnar, Frank Sommerhage, Jonathan Ernest Hood, Jerry Jenkins
  • Publication number: 20160305927
    Abstract: The invention provides a culture of patterned cardiomyocytes, the culture including a support substrate bearing a multielectrode array, a negative surface resistant to cell attachment and deposited on the support substrate covering the multi-electrode array, a pattern ablated on the negative surface, a positive surface promoting cell attachment deposited on the pattern ablated on the negative surface; and cardiomyocytes adherent to the positive surface and growing aligned along the pattern ablated on the negative surface. The invention also includes a method of making the culture of patterned cardiomyocytes and a method of in vitro method of testing the effect of a compound on cardiac function by measuring electrical output from the patterned cardiomyocytes.
    Type: Application
    Filed: June 23, 2016
    Publication date: October 20, 2016
    Inventors: Peter Molnar, Anupama Natarajan, Maria Stancescu, James Hickman