Abstract: A system for identification of a biological structure present in a liquid biopsy sample is provided. The system identifies common biological structures and rare biological structures based on their fluorescence characteristics and morphology. The identified biological structures may be used in diagnosis and treatment of a human afflicted with a disease. Examples described in this disclosure also relate to methods and assays that may be used together with the systems of this disclosure for diagnosis and treatment of a human afflicted with a disease.

Abstract: The present disclosure encompasses methods for molecularly subtyping formalin-fixed paraffin-embedded tumor samples. The disclosure works particularly well for old and degraded (archival) samples for which standard methods are unfeasible. Further, the methods disclosed allow for the correlation of patient outcome data with the molecular subtype of the tumor and provides a wealth of information which will guide treatment decisions and/or selection of therapeutic agents.

Abstract: The present invention provides a standard testing methodology for making quantitative determinations as to the chemical resistance of thermoplastics commonly used for non-disposable medical devices by evaluating the retention of tensile and/or impact properties of the thermoplastic materials after exposure to chemicals associated with healthcare grade disinfectants. Versions of the test methods may be used with any of a variety of different thermoplastic materials, each having a different stiffness or elastic modulus; and versions of the test methods may be used with any of a variety of different hospital grade cleaning agents or disinfectants. Using the methodology of embodiments of the present invention, different thermoplastic materials may be tested against different cleaners or disinfectants to provide a uniform basis for comparison.

Abstract: A method for obtaining from genomic material genomic copy number information unaffected by amplification distortion, comprising obtaining segments of the genomic material, tagging the segments with substantially unique tags to generate tagged nucleic acid molecules, such that each tagged nucleic acid molecule comprises one segment of the genomic material and a tag, subjecting the tagged nucleic acid molecules to amplification by polymerase chain reaction (PCR), generating tag associated sequence reads by sequencing the product of the PCR reaction, assigning each tagged nucleic acid molecule to a location on a genome associated with the genomic material by mapping the subsequence of each tag associated sequence read corresponding to a segment of the genomic material to a location on the genome, and counting the number of tagged nucleic acid molecules having a different tag that have been assigned to the same location on the genome, thereby obtaining genomic copy number information unaffected by amplification d

Abstract: The present invention provides a standard testing methodology for making quantitative determinations as to the chemical resistance of thermoplastics commonly used for non-disposable medical devices by evaluating the retention of tensile and/or impact properties of the thermoplastic materials after exposure to chemicals associated with healthcare grade disinfectants. Versions of the test methods may be used with any of a variety of different thermoplastic materials, each having a different stiffness or elastic modulus; and versions of the test methods may be used with any of a variety of different hospital grade cleaning agents or disinfectants. Using the methodology of embodiments of the present invention, different thermoplastic materials may be tested against different cleaners or disinfectants to provide a uniform basis for comparison.

Abstract: A method for obtaining from genomic material genomic copy number information unaffected by amplification distortion, comprising obtaining segments of the genomic material, tagging the segments with substantially unique tags to generate tagged nucleic acid molecules, such that each tagged nucleic acid molecule comprises one segment of the genomic material and a tag, subjecting the tagged nucleic acid molecules to polymerase chain reaction (PCR) amplification, generating tag associated sequence reads by sequencing the product of the PCR reaction, assigning each tagged nucleic acid molecule to a location on a genome associated with the genomic material by mapping the subsequence of each tag associated sequence read corresponding to a segment of the genomic material to a location on the genome, and counting the number of tagged nucleic acid molecules assigned to the same location on the genome having a different tag, thereby obtaining genomic copy number information unaffected by amplification distortion.

Abstract: A system for identification of a biological structure present in a liquid biopsy sample is provided. The system identifies common biological structures and rare biological structures based on their fluorescence characteristics and morphology. The identified biological structures may be used in diagnosis and treatment of a human afflicted with a disease. Examples described in this disclosure also relate to methods and assays that may be used together with the systems of this disclosure for diagnosis and treatment of a human afflicted with a disease.

Abstract: A cooling module, which is securable to one or more thermal transfer members for an LED curing apparatus, wherein the cooling module comprises a first finned heat sink and a second finned heat sink; wherein the first finned heat sink is removably securable to the second finned heat sink to provide at least one aperture therebetween, wherein each of a plurality of fins protrude from the first finned heat sink and from the second finned heat sink and each fin is substantially perpendicular to the length of the or each aperture, wherein the first finned heat sink is removably secured proximal to the second finned heat sink by at least one locking member, and wherein the or each locking member is inserted such that its length is parallel to the length of the or each aperture.

Abstract: A method includes receiving a request for enrollment from a user at a wallet service provider (WSP) computer, and enrolling the user in the WSP computer. A message is transmitted to the user to query the user about accepting payment card account system transactions. A response to the message, from the user, is received in the WSP computer. The WSP computer downloads, to a device operated by the user, a list of acquirer financial institutions. The WSP computer receives, from the device operated by the user, an indication that the user has selected one of the acquirer financial institutions from the list. An application program supplied by the selected acquirer financial institution is downloaded to the device operated by the user.

Abstract: In an approach to visualizing the transport of ground contaminants in an aquifer, a location and one or more aquifer properties are received from a user. One or more simulation parameters and one or more output parameters are received from the user. A transport simulation of the ground contaminants in the aquifer is performed. One or more output visualizations of the transport of the ground contaminants in the aquifer are generated.

Abstract: A method includes receiving a request for enrollment from a user at a wallet service provider (WSP) computer, and enrolling the user in the WSP computer. A message is transmitted to the user to query the user about accepting payment card account system transactions. A response to the message, from the user, is received in the WSP computer. The WSP computer downloads, to a device operated by the user, a list of acquirer financial institutions. The WSP computer receives, from the device operated by the user, an indication that the user has selected one of the acquirer financial institutions from the list. An application program supplied by the selected acquirer financial institution is downloaded to the device operated by the user.

Abstract: The present invention provides a standard testing methodology for making quantitative determinations as to the chemical resistance of thermoplastics commonly used for non-disposable medical devices by evaluating the retention of tensile and/or impact properties of the thermoplastic materials after exposure to chemicals associated with healthcare grade disinfectants. Versions of the test methods may be used with any of a variety of different thermoplastic materials, each having a different stiffness or elastic modulus; and versions of the test methods may be used with any of a variety of different hospital grade cleaning agents or disinfectants. Using the methodology of embodiments of the present invention, different thermoplastic materials may be tested against different cleaners or disinfectants to provide a uniform basis for comparison.

Abstract: An LED curing apparatus cooling system comprising at least one LED mount for mounting a plurality of LEDs; at least one bore in the LED mount; at least one thermal transfer member comprising an evaporator section and a condenser section, wherein the or each thermal transfer member is removably connected to a bore; and wherein each thermal transfer member comprises a collar having an outer surface to mate with an inner surface of a bore.

Abstract: A cooling module, which is securable to one or more thermal transfer members for an LED curing apparatus, wherein the cooling module comprises a first finned heat sink and a second finned heat sink; wherein the first finned heat sink is removably securable to the second finned heat sink to provide at least one aperture therebetween, wherein each of a plurality of fins protrude from the first finned heat sink and from the second finned heat sink and each fin is substantially perpendicular to the length of the or each aperture, wherein the first finned heat sink is removably secured proximal to the second finned heat sink by at least one locking member, and wherein the or each locking member is inserted such that its length is parallel to the length of the or each aperture.

Abstract: An LED curing apparatus comprising at least one LED radiation source mounted on an LED mount; a housing comprising at least one air inlet; at least one finned heat sink; and at least one air passage through the housing from the or each air inlet through the or each finned heat sink to at least one air outlet; wherein the housing comprises an inlet cavity below the or each finned heat sink and an outlet cavity above the or each finned heat sink to maintain a higher air pressure below the or each finned heat sink and a lower air pressure above the or each finned heat sink.

Abstract: An audio output device comprises a loudspeaker and, four stem control inputs substantially even spaced on the upper surface of a housing. The stem control inputs are each divided into four segments, each comprising a touch sensor and an illumination unit. Each stem control input is associated with a different stem in an audio track for playback via the loudspeaker. Touching the segments of each stem control input results in the touch being detected and a touch signal being output by the respective segment. In response to a touch signal, the associated illumination unit is togged on/off and a property of the associated stem is varied during playback by loudspeaker.

Abstract: A touch sensitive audio-visual input/output device comprising an internal core comprising a controller, the controller associated with at least one processor and at least one memory store, at least one light emitter associated with the controller, at least one audio output component associated with the controller, at least one actuator provided relative to the housing and associated with the controller and configured to transmit touch inputs to the controller to control operation of the device, and a flexible, translucent outer casing for at least partially enclosing the internal core.

Abstract: An audio output device comprises a loudspeaker and, four stem control inputs substantially even spaced on the upper surface of a housing. The stem control inputs are each divided into four segments, each comprising a touch sensor and an illumination unit. Each stem control input is associated with a different stem in an audio track for playback via the loudspeaker. Touching the segments of each stem control input results in the touch being detected and a touch signal being output by the respective segment. In response to a touch signal, the associated illumination unit is togged on/off and a property of the associated stem is varied during playback by loudspeaker.

Abstract: The present invention provides methods and compositions related to genomic profiling, and in particular, to assigning probabilistic measure of clinical outcome for a patient having a disease or a tumor using segmented genomic profiles such as those produced by representational oligonucleotide microarray analysis (ROMA).

Abstract: A touch sensitive audio-visual input/output device comprising an internal core comprising a controller, the controller associated with at least one processor and at least one memory store, at least one light emitter associated with the controller, at least one audio output component associated with the controller, at least one actuator provided relative to the housing and associated with the controller and configured to transmit touch inputs to the controller to control operation of the device, and a flexible, translucent outer casing for at least partially enclosing the internal core.