Abstract: Disclosed herein is a method for the prevention, delay of progression or treatment of indolent or aggressive B-cell lymphomas in an individual in need thereof, comprising administering a Btk inhibitor (in particularly (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo-[1,5-a]pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof) in combination with an anti-PD-1 antibody. The potent and selective BTK inhibitor in combination with the anti-PD-1 antibody have a manageable toxicity profile in patients with indolent and aggressive lymphomas.

Abstract: Disclosed herein is a method for the prevention, delay of progression or treatment of indolent or aggressive B-cell lymphomas in an individual in need thereof, comprising administering a Btk inhibitor (in particularly (S)-7-(1-actyloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo-[1,5-a]pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof) in combination with an anti-PD-1 antibody. The potent and selective BTK inhibitor in combination with the anti-PD-1 antibody have a manageable toxicity profile in patients with indolent and aggressive lymphomas.

Abstract: Disclosed herein is a method for the prevention, delay of progression or treatment of indolent or aggressive B-cell lymphomas in an individual in need thereof, comprising administering a Btk inhibitor (in particularly (S)-7-(1-actyloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo-[1,5-a]pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof) in combination with an anti-PD-1 antibody. The potent and selective BTK inhibitor in combination with the anti-PD-1 antibody have a manageable toxicity profile in patients with indolent and aggressive lymphomas.

Abstract: An exemplary embodiment of the present invention is directed to a malleable flattened rectangular lingual retainer wire that is configured to be integrally shaped and bonded to the inside surfaces of teeth for a prolonged period of time. The lingual retainer wire acts to secure the teeth to one another in a manner that provides precise root position control. The lingual retainer wire is a single strand of wire that has been flattened in order to reduce its profile allowing the lingual retainer wire to be placed on the inside of either the upper or lower incisor teeth without interfering with occlusion.

Abstract: A computer system for a system interaction matrix creation tool is provided. The computer system has a platform, at least one input device, and a central processing unit in communication with the platform and the at least one input device. The central processing unit is configured to display a system interaction matrix having a first dimension indexed to a plurality of affecting subsystems, and a second dimension indexed to a plurality of affected subsystems, receive a selection of one of the plurality affecting subsystems and a selection of one of the plurality of affected subsystems, and receive a selection of one of a plurality of types of interactions existing between the selected one of the plurality of affecting subsystems and the selected one of the plurality of affected subsystems. The central processing unit is further configured to receive a description of the selected interaction.