Abstract: A system, in certain embodiments, includes a centrifugal compressor diffuser including a flow path having a first surface and a second surface defining opposite axial sides of the flow path. The centrifugal compressor diffuser also includes multiple vanes extending from the first surface to the second surface of the flow path. A first profile of each vane varies along an axial direction. The centrifugal compressor diffuser further includes multiple vanelets extending from the first surface toward the second surface in the axial direction. A first axial extent of each vanelet is less than a second axial extent of the flow path. In addition, a second profile of each vanelet varies along the axial direction and/or the vanelets form a non-periodic pattern around a circumference of the flow path.

Abstract: A system, in certain embodiments, includes an impeller having a plurality of impeller blades coupled to an impeller hub body, wherein each impeller blade is sculpted having a nonlinear profile extending from a hub intersect surface of the impeller blade to a shroud intersect surface of the impeller blade.

Abstract: A system, in certain embodiments, includes a centrifugal compressor diffuser including a flow path having a first surface and a second surface defining opposite axial sides of the flow path. The centrifugal compressor diffuser also includes multiple vanes extending from the first surface to the second surface of the flow path. A first profile of each vane varies along an axial direction. The centrifugal compressor diffuser further includes multiple vanelets extending from the first surface toward the second surface in the axial direction. A first axial extent of each vanelet is less than a second axial extent of the flow path. In addition, a second profile of each vanelet varies along the axial direction and/or the vanelets form a non-periodic pattern around a circumference of the flow path.

Abstract: A system, in certain embodiments, includes a centrifugal compressor diffuser including a flow path having a first surface and a second surface defining opposite axial sides of the flow path. The centrifugal compressor diffuser also includes multiple vanes extending from the first surface to the second surface of the flow path. A first profile of each vane varies along an axial direction. The centrifugal compressor diffuser further includes multiple vanelets extending from the first surface toward the second surface in the axial direction. A first axial extent of each vanelet is less than a second axial extent of the flow path. In addition, a second profile of each vanelet varies along the axial direction and/or the vanelets form a non-periodic pattern around a circumference of the flow path.

Abstract: A system, in certain embodiments, includes an impeller having a plurality of impeller blades coupled to an impeller hub body, wherein each impeller blade is sculpted having a nonlinear profile extending from a hub intersect surface of the impeller blade to a shroud intersect surface of the impeller blade.

Abstract: A system, in certain embodiments, includes a centrifugal compressor diffuser having a mounting surface and plurality of diffuser vanes extending from the mounting surface in an axial direction and forming an asymmetrical (e.g., non-periodic) pattern around the circumference of the diffuser. The asymmetrical pattern may be determined based upon characteristics of fluid flowing from an impeller across the diffuser and through a scroll of a centrifugal compressor.

Abstract: A system, in certain embodiments, includes a centrifugal compressor diffuser including a flow path having a first surface and a second surface defining opposite axial sides of the flow path. The centrifugal compressor diffuser also includes multiple vanes extending from the first surface to the second surface of the flow path. A first profile of each vane varies along an axial direction. The centrifugal compressor diffuser further includes multiple vanelets extending from the first surface toward the second surface in the axial direction. A first axial extent of each vanelet is less than a second axial extent of the flow path. In addition, a second profile of each vanelet varies along the axial direction and/or the vanelets form a non-periodic pattern around a circumference of the flow path.

Abstract: Inhalable compositions are described. The inhalable compositions comprise one or more respirable aggregates, the respirable aggregates comprising one or more poorly water soluble active agents, wherein at least one of the active agents reaches a maximum lung concentration (Cmax) of at least about 0.25 ?g/gram of lung tissue and remains at such concentration for a period of at least one hour after being delivered to the lung. Methods for making such compositions and methods for using such compositions are also disclosed.

Abstract: The present invention provides various processes for the preparation of (R)-?-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol.