Patents by Inventor James Holms

James Holms has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bromodomain Inhibitors
    Publication number: 20190084981
    Abstract: The present invention provides for compounds of formula (I) wherein Rx, Ry, Rx1, L1, G1, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
    Type: Application
    Filed: November 16, 2018
    Publication date: March 21, 2019
    Inventors: Yujia Dai, Steven D. Fidanze, Lisa Hasvold, James Holms, Dachun Liu, William McClellan, Keith McDaniel, Jasmina Marjanovic, George Sheppard, Le Wang
  • Bromodomain inhibitors
    Patent number: 10131657
    Abstract: The present invention provides for compounds of formula (I). wherein Rx, Ry, Rx1, L1, G1, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: November 20, 2018
    Assignee: AbbVie Inc.
    Inventors: Yujia Dai, Steven D. Fidanze, Lisa Hasvold, James Holms, Dachun Liu, William McClellan, Keith McDaniel, Jasmina Marjanovic, George Sheppard, Le Wang
  • Bromodomain inhibitors
    Patent number: 9957263
    Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided. The compounds are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Pharmaceutical compositions comprised of one or more compounds of formula (I) are also provided.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: May 1, 2018
    Assignee: AbbVie Inc.
    Inventors: Yujia Dai, Steven D. Fidanze, Lisa Hasvold, James Holms, Dachun Liu, William McClellan, Keith McDaniel, Jasmina Marjanovic, George Sheppard, Le Wang
  • Bromodomain Inhibitors
    Publication number: 20160272630
    Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided. The compounds are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Pharmaceutical compositions comprised of one or more compounds of formula (I) are also provided.
    Type: Application
    Filed: June 27, 2014
    Publication date: September 22, 2016
    Applicant: AbbVie Inc.
    Inventors: Yujia Dai, Steven D. Fidanze, Lisa Hasvold, James Holms, Dachun Liu, William McClellan, Keith McDaniel, Jasmina Marjanovic, George Sheppard, Le Wang
  • Bromodomain Inhibitors
    Publication number: 20160185769
    Abstract: The present invention provides for compounds of formula (I). wherein Rx, Ry, Rx1, L1, G1, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
    Type: Application
    Filed: May 13, 2014
    Publication date: June 30, 2016
    Applicant: Abbvie Inc.
    Inventors: Yujia Dai, Steven D. Fidanze, Lisa Hasvold, James Holms, Dachun Liu, William McClellan, Keith McDaniel, Jasmina Marjanovic, George Sheppard, Le Wang
  • Pyrrolopyridine inhibitors of kinases
    Patent number: 8435980
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: May 7, 2013
    Assignee: AbbVie Inc.
    Inventors: Alan S. Florjancic, Yunsong Tong, Thomas D. Penning, Jane Gong, Magdalena Przytulinska, Douglas Steinman, James Holms, Chunqiu Lai, Gui-Dong Zhu, Keith Woods
  • Inhibitors of protein kinases
    Publication number: 20070135387
    Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
    Type: Application
    Filed: December 8, 2006
    Publication date: June 14, 2007
    Inventors: Michael Michaelides, William McClellan, Robin Frey, Michael Curtin, Douglas Steinman, Yujia Dai, James Holms
  • Isoindolinone kinase inhibitors
    Publication number: 20060287370
    Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Application
    Filed: August 25, 2006
    Publication date: December 21, 2006
    Inventors: Michael Curtin, Steven Davidsen, Robin Frey, Howard Heyman, James Holms, Michael Michaelides, Douglas Steinman
  • Aminobenzoxazoles as therapeutic agents
    Publication number: 20060025383
    Abstract: A compound of Formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors.
    Type: Application
    Filed: February 3, 2005
    Publication date: February 2, 2006
    Inventors: Neil Wishart, Michael Friedman, Lee Arnold, Bryant Yang, Shannon Fix-Stenzel, Anna Ericsson, Michael Michaelides, Xiao-Dong Qian, James Holms, Douglas Steinman, Zhengping Tian, Steven Wittenberger
  • Tricyclic pyrazole kinase inhibitors
    Publication number: 20060014816
    Abstract: Compounds of the present invention are useful for inhibiting protein tyrosine kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Application
    Filed: March 24, 2005
    Publication date: January 19, 2006
    Inventors: Lee Arnold, Jurgen Dinges, Richard Dixon, Stevan Djuric, Anna Ericsson, Kimba Fischer, Alan Gasiecki, Vijaya Gracias, James Holms, Makoto Takeshita, Michael Michaelides, Melanie Muckey, Paul Rafferty, Douglas Steinman, Carol Wada, Zhiren Xia, Irini Akritopoulou-Zanze, Henry Zhang
  • Isoindolinone kinase inhibitors
    Publication number: 20050026976
    Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Application
    Filed: June 2, 2004
    Publication date: February 3, 2005
    Inventors: Michael Curtin, Steven Davidsen, Robin Frey, Howard Heyman, James Holms, Michael Michaelides, Douglas Steinman