Patents by Inventor James Hoxie

James Hoxie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-Signaling HIV Fusion Inhibitors And Methods Of Use Thereof
    Publication number: 20210338731
    Abstract: The present invention relates to engineered cells expressing a fusion protein comprising a peptide fusion inhibitor and a CXCR4 protein that lacks signaling activity. Also provided are methods of suppressing, inhibiting, preventing or treating a HIV infection in a subject in need thereof using the engineered cells.
    Type: Application
    Filed: May 3, 2021
    Publication date: November 4, 2021
    Inventors: James L. Riley, James A. Hoxie, George J. Leslie, Max W. Richardson
  • Cytoplasmic Tail Modifications to Boost Surface Expression and Immunogenicity of Envelope Glycoproteins
    Publication number: 20150203540
    Abstract: The invention provides compositions and methods for enhanced expression of a viral envelope protein. The invention provides a composition comprising a cytoplasmic tail modification to enhance surface expression of both HIV and non-HIV viral envelope proteins as wells as other membrane associated proteins resulting in increased immunogenicity.
    Type: Application
    Filed: July 26, 2013
    Publication date: July 23, 2015
    Inventors: James A. Hoxie, Jordan Andrea Polacchini-Oliviera, Angela Conde, Drew Weissman
  • Method for the production of antibodies that bind to multiple membrane spanning proteins
    Patent number: 8680244
    Abstract: Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: March 25, 2014
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Robert Doms, Joseph Rucker, Trevor L Hoffman, Paul Bates, James A Hoxie, Michael J Endres, John Balliet, Dennis L Kolson
  • LIPOPARTICLE COMPRISING A PROTEIN AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20120195882
    Abstract: Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.
    Type: Application
    Filed: March 15, 2012
    Publication date: August 2, 2012
    Inventors: Robert Doms, Joseph Rucker, Trevor L. Hoffman, Paul Bates, James Hoxie, Michael Endres, John Balliet, Dennis Kolson
  • Method for the preparation of virus-like particles (VLPS) comprising heterologous multiple membrane spanning proteins
    Patent number: 8158130
    Abstract: Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: April 17, 2012
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Robert W Doms, Joseph Rucker, Trevor L Hoffman, Paul Bates, James A Hoxie, Michael J Endres, John Balliet, Dennis L Kolson
  • LIPOPARTICLE COMPRISING A PROTEIN AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20100272746
    Abstract: Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.
    Type: Application
    Filed: March 9, 2010
    Publication date: October 28, 2010
    Inventors: Robert Doms, Joseph Rucker, Trevor L. Hoffman, Paul Bates, James Hoxie, Michael Endres, John Balliet, Dennis Kolson
  • Virus-like particles (VLPs) comprising heterologous multiple membrane spanning proteins
    Patent number: 7763258
    Abstract: Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: July 27, 2010
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Robert Doms, Joseph Rucker, Trevor L. Hoffman, Paul Bates, James Hoxie, Michael Endres, John Balliet, Dennis Kolson
  • Compositions, method and kits relating to deletion mutations of immunodeficiency virus gp120 hypervariable regions
    Patent number: 7524927
    Abstract: The present invention relates to replication competent variants of mammalian immunodeficiency virus comprising mutations and/or deletions of the V3 hypervariable loop and compensatory mutations, as well as methods for producing such variants. The invention also relates to V3-loop deletion mammalian immunodeficiency virus mutants that have compensatory mutations, deletions of the V1/V2 loops, or both. The invention further relates to isolated Env, gp120 polypeptides, and gp41 polypeptides comprising novel mutations useful in conjunction with, or separate from, a virus of the invention, as well as nucleic acids encoding the same.
    Type: Grant
    Filed: January 29, 2004
    Date of Patent: April 28, 2009
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James A. Hoxie, George Lin
  • CD4-independent HIV envelope proteins as vaccines and therapeutics
    Patent number: 7371846
    Abstract: The invention relates to novel CD4-independent HIV Envelope proteins and uses therefor.
    Type: Grant
    Filed: February 1, 2005
    Date of Patent: May 13, 2008
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James A. Hoxie, Celia C. LaBranche, Robert W. Doms, Trevor L. Hoffman
  • CD4-independent HIV envelope proteins as vaccines and therapeutics
    Publication number: 20050191621
    Abstract: The invention relates to novel CD4-independent HIV Envelope proteins and uses therefor.
    Type: Application
    Filed: February 1, 2005
    Publication date: September 1, 2005
    Inventors: James Hoxie, Celia LaBranche, Robert Doms, Trevor Hoffman
  • Compositions, methods and kits relating to deletion mutations of immunodeficiency virus gp120 hypervariable regions
    Publication number: 20050064392
    Abstract: The present invention relates to replication competent variants of mammalian immunodeficiency virus comprising mutations and/or deletions of the V3 hypervariable loop and compensatory mutations, as well as methods for producing such variants. The invention also relates to V3-loop deletion mammalian immunodeficiency virus mutants that have compensatory mutations, deletions of the V1/V2 loops, or both. The invention further relates to isolated Env, gp120 polypeptides, and gp41 polypeptides comprising novel mutations useful in conjunction with, or separate from, a virus of the invention, as well as nucleic acids encoding the same.
    Type: Application
    Filed: January 29, 2004
    Publication date: March 24, 2005
    Inventors: James Hoxie, George Lin
  • CD4-independent HIV envelope proteins as vaccines and therapeutics
    Patent number: 6849261
    Abstract: The invention relates to novel CD4-independent HIV Envelope proteins and uses therefor.
    Type: Grant
    Filed: July 16, 2002
    Date of Patent: February 1, 2005
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James A. Hoxie, Celia C. LaBranche, Robert W. Doms, Trevor L. Hoffman
  • CD4-independent HIV envelope proteins as vaccines and therapeutics
    Publication number: 20030091594
    Abstract: The invention relates to novel CD4-independent HIV Envelope proteins and uses therefor.
    Type: Application
    Filed: July 16, 2002
    Publication date: May 15, 2003
    Applicant: University of Pennsylvania
    Inventors: James A. Hoxie, Celia C. LaBranche, Robert W. Doms, Trevor L. Hoffman
  • Lipoparticle comprising a protein and methods of making and using the same
    Publication number: 20020183247
    Abstract: Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.
    Type: Application
    Filed: December 21, 2001
    Publication date: December 5, 2002
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Robert W. Doms, Joseph Rucker, Trevor L. Hoffman, Paul Bates, James A. Hoxie
  • CD4-independent HIV envelope proteins as vaccines and therapeutics
    Patent number: 6420545
    Abstract: The invention relates to novel CD4-independent HIV Envelope proteins and uses therefor.
    Type: Grant
    Filed: June 22, 1999
    Date of Patent: July 16, 2002
    Assignees: The Trustees of the University of Pennsylvania, Duke University
    Inventors: James A. Hoxie, Celia C. LaBranche, Robert W. Doms, Trevor L. Hoffman
  • Antibodies directed against cellular coreceptors for human immunodeficiency virus and methods of using the same
    Patent number: 5994515
    Abstract: The invention relates to an anti-immunodeficiency virus antibody which binds to a cellular protein and diagnostic and therapuetic methods of using the same.
    Type: Grant
    Filed: June 25, 1997
    Date of Patent: November 30, 1999
    Assignee: Trustees of the University of Pennsylvania
    Inventor: James A. Hoxie
  • Method and kit for detection of thrombin receptor activation of platelets and other cells
    Patent number: 5840499
    Abstract: Method for detecting thrombin-induced cell activation via a system of detection capable of determining the presence of the cleaved peptide fragment of the thrombin receptor are provided. These methods are used in diagnosing and treating a pre-thrombotic state or thrombotic disorder in a patient. Detection kits to be used with this method are also provided.
    Type: Grant
    Filed: June 6, 1996
    Date of Patent: November 24, 1998
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Lawrence Brass, James A. Hoxie
  • Antibodies directed against cellular coreceptors for human immunodeficiency virus and methods of using the same
    Patent number: RE39057
    Abstract: The invention relates to an anti-immunodeficiency virus antibody which binds to a cellular protein and diagnostic and therapuetic methods of using the same.
    Type: Grant
    Filed: April 22, 2004
    Date of Patent: April 4, 2006
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: James A. Hoxie