Abstract: The disclosure provides systems, devices, and associated methods for mitigating traumatic brain injury, injury to an ocular structure, or injury to the inner ear of a subject by applying pressure to one or more neck veins before and during an injurious event.

Abstract: Disclosed herein are antibodies directed against CRTAM, nucleic acids encoding such antibodies, host cells comprising such nucleic acids encoding the antibody, methods for preparing anti-CRTAM antibodies, and methods for the treatment of diseases, e.g., human cancers, including but not limited to small cell lung cancer, non-small cell lung cancer (including squamous carcinomas and adenocarcinomas) skin cancer including melanoma, breast cancer (including TNBC), colorectal cancer, gastric cancer, ovarian cancer, cervical cancer, prostate cancer, kidney cancer, liver cancer including hepatocellular carcinoma, pancreatic cancer, head and neck cancer, nasopharyngeal cancer, oesophageal cancer, bladder cancer and other uroepithelial cancers, stomach cancer, glioma, glioblastoma, testicular, thyroid, bone, gallbladder and bile ducts, uterine, adrenal cancers, sarcomas, GIST, neuroendocrine tumours, and haematological malignancies.

Abstract: The present disclosure provides methods of treating B-cell malignancy in a subject with a Bcl-2 inhibitor, in particularly 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-N-((4-((((1r,4r)-4-hydroxy-4-methylcyclohexyl)methyl)amino)-3-nitrophenyl)sulfonyl)-4-(2-((S)-2-(2-isopropylphenyl)pyrrolidin-1-yl)-7-azaspiro[3.5]nonan-7-yl)benzamide or a pharmaceutically acceptable salt thereof, or its combination with a Bruton's tyrosine kinase (BTK) inhibitor, particularly (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo-[1,5-a]pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof.

Abstract: Techniques are described for automating the design of dental restoration appliances using neural networks. An example computing device receives transform information associated with a current dental anatomy of a dental restoration patient, provides the transform information associated with the current dental anatomy of the dental restoration patient as input to a neural network trained with transform information indicating placement of a dental appliance component with respect to one or more teeth of corresponding dental anatomies, the dental appliance being used for dental restoration treatment for the one or more teeth, and executes the neural network using the input to produce placement information for the dental appliance component with respect to the current dental anatomy of the dental restoration patient.

Abstract: A method includes forming a conductive material on a first dielectric layer, exposing the conductive material to aniline to produce a passivated surface of the conductive material, and after exposing the conductive material to aniline, forming a second dielectric layer on the first dielectric layer using a deposition process. The deposition process is a water-free and plasma-free deposition process, and the second dielectric layer does not form on the passivated surface of the conductive material.

Abstract: Disinfectant compositions are disclosed which provide a durable residual antimicrobial benefit to surfaces treated with such compositions. The disinfectant compositions include a biocidal agent, an amphoteric copolymer, and other functional agents. Methods of making and using the disinfectant compositions are further provided.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for performing neural architecture search for machine learning models. In one aspect, a method comprises receiving training data for a machine learning, generating a plurality of candidate neural networks for performing the machine learning task, wherein each candidate neural network comprises a plurality of instances of a layer block composed of a plurality of layers, for each candidate neural network, selecting a respective type for each of the plurality of layers from a set of layer types that comprises, training the candidate neural network and evaluating performance scores for the trained candidate neural networks as applied to the machine learning task, and determining a final neural network for performing the machine learning task based at least on the performance scores for the candidate neural networks.

Abstract: The present invention provides methods for sequencing and analysis of nucleic acids and determining that a subject is positive for a non-usual interstitial pneumonia subtype.

Abstract: Methods, systems, and devices for wireless communications are described. In some wireless communications systems, a wireless device may buffer uplink communications. However, such approaches may be improved. An access point (AP) may receive, from a station, uplink traffic of a traffic flow for forwarding to a backhaul network via a backhaul link. The AP may monitor a buffer of the AP to determine that a quantity of buffered uplink traffic received from the station exceeds a buffer quota, the buffer quota set for the traffic flow based on a traffic throughput capacity of the backhaul link and a throughput parameter for the traffic flow. The AP may modify, based on the quantity of buffered uplink traffic exceeding the buffer quota, an uplink communication scheme to reduce the quantity of uplink traffic from the station.

Abstract: Computer-implemented method and system for receiving and processing one or more moment-associating elements. For example, the computer-implemented method includes receiving the one or more moment-associating elements, transforming the one or more moment-associating elements into one or more pieces of moment-associating information, and transmitting at least one piece of the one or more pieces of moment-associating information.

Abstract: Asphalt binders and related methods and uses are provided. In some embodiments, the asphalt binder is produced by: providing a high-asphaltene content petroleum feedstock; performing solvent deasphalting on the feedstock to produce a partially deasphalted oil and an asphaltene-rich residue; and collecting the partially deasphalted oil (DAO). The high-asphaltene content petroleum feedstock may comprise residue from vacuum distillation or flash separation of extra heavy oil or bitumen, or recycled asphalt. The DAO may itself be used as the asphalt binder or may be a component of a blend with the original feedstock. Asphalt binders may also be produced by blending residue and heavy distillate produced from vacuum distillation or flash separation, with DAO or the asphaltene-rich residue of the solvent deasphalting process. The disclosed methods allow for production of asphalt binders of a wide variety of performance grades.

Abstract: Compositions and kits for diagnosing and prognosing Alzheimer's Disease (AD) in a human patient include a binding agent such as a monoclonal antibody for a biomarker conjugated to a detectable moiety such as a fluorophore, wherein the biomarker is chosen from CD11c, CD59, CD91, and CD163 and other phagocytosis-related molecules. Further compositions and kits employ panels of fluorophore-conjugated monoclonal antibodies for biomarkers including scavenger receptors. Methods for determining the relative expression of biomarkers, diagnosing AD, and determining the efficacy of AD therapeutic candidates such as phagocytosis-promoting agents and scavenger receptor agonists also appear.

Abstract: The invention relates to the synthesis of a carboxyl-functional, unsaturated polyurethane containing a perfluoropolyether block, which can be used as an easy clean additive in preparation of a waterborne, UV curable coating composition. The polyurethane can be prepared by a method comprising the following steps: a) subjecting a hydroxy-terminated perfluoropolyether A to a reaction with a molar excess of polyisocyanate B to obtain an isocyanate-functional urethane C, b) adding a carboxyl-functional polyol D to the reaction mixture, c) adding OH— functional (meth)acrylate monomer E to the reaction mixture, wherein steps (b) and (c) can be performed in any order, and d) neutralizing the reaction product with a neutralizer F. The resulting coating has easy clean and anti-stain properties.

Abstract: The invention relates to an aqueous dispersion containing a mixture of linear fluorinated and non-fluorinated polyurethane acrylates, obtainable by: a) reacting polyisocyanate A?, multi-unsaturated OH-functional compound B?, acid-functional polyol C? under urethane formation reaction conditions in the presence of intermediate X, wherein intermediate X is an OH-functional (per)fluoropolyether (PFPE) derivative, and b) adding neutralizer D to the reaction product of step a) and dispersing it in water. The dispersion can be used in preparation of a coating with easy-clean, anti-stain and anti-scratch properties, which can advantageously be used for coating substrates in consumer electronics or automotive applications.

Abstract: Embodiments described and discussed herein provide methods for selectively depositing a metal oxides on a substrate. In one or more embodiments, methods for forming a metal oxide material includes positioning a substrate within a processing chamber, where the substrate has passivated and non-passivated surfaces, exposing the substrate to a first metal alkoxide precursor to selectively deposit a first metal oxide layer on or over the non-passivated surface, and exposing the substrate to a second metal alkoxide precursor to selectively deposit a second metal oxide layer on the first metal oxide layer. The method also includes sequentially repeating exposing the substrate to the first and second metal alkoxide precursors to produce a laminate film containing alternating layers of the first and second metal oxide layers. Each of the first and second metal alkoxide precursors contains a different metal selected from titanium, zirconium, hafnium, aluminum, or lanthanum.

Abstract: Embodiments described and discussed herein provide methods for selectively depositing a metal oxides on a substrate. In one or more embodiments, methods for forming a metal oxide material includes positioning a substrate within a processing chamber, where the substrate has passivated and non-passivated surfaces, exposing the substrate to a first metal alkoxide precursor to selectively deposit a first metal oxide layer on or over the non-passivated surface, and exposing the substrate to a second metal alkoxide precursor to selectively deposit a second metal oxide layer on the first metal oxide layer. The method also includes sequentially repeating exposing the substrate to the first and second metal alkoxide precursors to produce a laminate film containing alternating layers of the first and second metal oxide layers. Each of the first and second metal alkoxide precursors contain different types of metals which are selected from titanium, zirconium, hafnium, aluminum, or lanthanum.

Abstract: In one embodiment, an article of footwear including an upper is described. The upper includes a braid body and at least one component. The braid body includes at least one braided layer. A reinforcement element is attached to the braid body along a connection area using a connecting stitch. The component is attached to the braid body at the connection area using a zigzag stitch including a thread that passes through the component at a first location and passes through the reinforcement element and the braid body at a second location. The second location extends beyond the connecting stitch attaching the reinforcement element to the braid body.

Abstract: Embodiments described and discussed herein provide methods for selectively depositing a metal oxides on a substrate. In one or more embodiments, methods for forming a metal oxide material includes positioning a substrate within a processing chamber, where the substrate has passivated and non-passivated surfaces, exposing the substrate to a first metal alkoxide precursor to selectively deposit a first metal oxide layer on or over the non-passivated surface, and exposing the substrate to a second metal alkoxide precursor to selectively deposit a second metal oxide layer on the first metal oxide layer. The method also includes sequentially repeating exposing the substrate to the first and second metal alkoxide precursors to produce a laminate film containing alternating layers of the first and second metal oxide layers. Each of the first and second metal alkoxide precursors contain different types of metals which are selected from titanium, zirconium, hafnium, aluminum, or lanthanum.

Abstract: In one embodiment, an article of footwear including an upper is described. The upper includes a braid body and at least one component. The braid body includes at least one braided layer. A reinforcement element is attached to the braid body along a connection area using a connecting stitch. The component is attached to the braid body at the connection area using a zigzag stitch including a thread that passes through the component at a first location and passes through the reinforcement element and the braid body at a second location. The second location extends beyond the connecting stitch attaching the reinforcement element to the braid body.

Abstract: An apparatus for an alpha trim adjustment includes a phase delay circuit that creates a phase delay for a gate signal for a switching cycle. The gate signal is for a phase of a three-phase, phase shifted alternating current (“AC”) input of a multi-pulse motor drive powering a direct current (“DC”) motor. The apparatus includes an alpha trim circuit that modifies the phase delay with an alpha trim adjustment to create an adjusted phase delay for the switching cycle, a delay application circuit that applies the adjusted phase delay to the gate signal.