Patents by Inventor James Hui

James Hui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF COMPLEMENT FACTOR D INHIBITORS ALONE OR IN COMBINATION WITH ANTI-C5 ANTIBODIES FOR TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA
    Publication number: 20230172930
    Abstract: Provided are methods for treating paroxysmal nocturnal hemoglobinuria in a subject who previously exhibited an inadequate response to an anti-C5 antibody therapy, by administering to the subject a therapeutically effective amount of an inhibitor of the alternative pathway of complement (e.g., one which inhibits a target upstream to complement 5 (C5), such as Factor D or complement 3 (C3)). Also provided herein are methods for treating PNH in a human subject, comprising administering to the subject a complement factor D inhibitor alone or in combination with an anti-C5 antibody, or antigen binding fragment thereof. In some embodiments, the patient previously exhibited an inadequate response to an anti-C5 antibody therapy.
    Type: Application
    Filed: May 11, 2021
    Publication date: June 8, 2023
    Applicant: Alexion Pharmaceuticals, Inc.
    Inventors: Mingjun Huang, James Hui, Steven Podos, Dharaben Patel, Michael Geffner
  • Combination Therapy Regimen For Treatment Of Selected HCV Genotypes
    Publication number: 20180021360
    Abstract: A method for the treatment of hepatitis C infection genotype 1, 2, 4, 5, or 6, but not genotype 3 is provided comprising administering an effective amount of a combination of Compound (I), Compound (II), and Compound (III), or independently optionally their pharmaceutically acceptable salt, solvate or hydrate, optionally in a solid fixed dose composition.
    Type: Application
    Filed: July 21, 2017
    Publication date: January 25, 2018
    Applicants: Janssen Pharmaceuticals, Inc., Achillion Pharmaceuticals, Inc.
    Inventors: Maria Gloria Beumont, Lieve Bijnens, Lawrence M. Blatt, Sushmita Mukherjee Chanda, John Fry, Eugene Jans, Thomas Naoki Kakuda, Sivi Mahadevan, Roel Mertens, Gaston Rafael Picchio, Alex Van Dijck, Peter Van Remoortere, David Apelian, Dawei Chen, Milind Deshphande, James Hui, Avinash Phadke
  • COMBINATION DRUG TREATMENT FOR HEPATITIS C INFECTION
    Publication number: 20180021361
    Abstract: A method for the treatment of hepatitis C infection genotype 1, 2, 4, 5, or 6 is provided comprising administering an effective amount of a combination of Compound (I), Compound (II), and Compound (III), or independently optionally their pharmaceutically acceptable salt, solvate or hydrate, optionally in a solid fixed dose composition.
    Type: Application
    Filed: July 21, 2017
    Publication date: January 25, 2018
    Applicants: JANSSEN PHARMACEUTICALS, INC., ACHILLION PHARMACEUTICALS, INC.
    Inventors: Maria Gloria Beumont, Lieve Bijnens, Lawrence M. Blatt, Sushmita Mukherjee Chanda, John Fry, Eugene Jans, Thomas Naoki Kakuda, Sivi Mahadevan, Roel Mertens, Gaston Rafael Picchio, Alex Van Dijck, Peter Van Remoortere, David Apelian, Dawei Chen, Milind Deshphande, James Hui, Avinash Phadke
  • COMBINATION DRUG TREATMENT FOR HEPATITIS C INFECTION
    Publication number: 20170319572
    Abstract: A composition, including a fixed dose composition, comprising Compound (I), Compound (II), and Compound (III) for the treatment of hepatitis C, and methods of manufacture thereof.
    Type: Application
    Filed: July 25, 2017
    Publication date: November 9, 2017
    Applicants: JANSSEN PHARMACEUTICALS, INC., ACHILLION PHARMACEUTICALS, INC.
    Inventors: Maria Gloria Beumont, Lieve Bijnens, Lawrence M. Blatt, Sushmita Mukherjee Chanda, John Fry, Eugene Jans, Thomas Naoki Kakuda, Sivi Mahadevan, Roel Mertens, Gaston Rafael Picchio, Alex Van Dijck, Peter Van Remoortere, David Apelian, Dawei Chen, Milind Deshphande, James Hui, Avinash Phadke
  • COMBINATION THERAPY REGIMEN FOR TREATMENT OF HCV
    Publication number: 20170087174
    Abstract: A composition, including a fixed dose composition, comprising Compound (I), Compound (II), and Compound (III) for the treatment of hepatitis C, and methods of manufacture thereof.
    Type: Application
    Filed: September 29, 2016
    Publication date: March 30, 2017
    Inventors: Maria Gloria Beumont, Lieve Bijnens, Lawrence M. Blatt, Sushmita Mukherjee Chanda, John Fry, Eugene Jans, Thomas Naoki Kakuda, Sivi Mahadevan, Roel Mertens, Gaston Rafael Picchio, Alex Van Dijck, Peter Van Remoortere, David Apelian, Dawei Chen, Milind Deshphande, James Hui, Avinash Phadke
  • Composition for assaying cardiac glycosides from serum or plasma
    Patent number: 4764601
    Abstract: A fluorescent compound is made from the reaction of naphthoyl chloride and a cardiac glycoside derived from serum or plasma. The method of carrying out the reaction provides a product which allows for a 100-fold increase in sensitivity when the product is subjected to chromatographic analysis according to the described apparatus.
    Type: Grant
    Filed: October 18, 1985
    Date of Patent: August 16, 1988
    Assignee: The Ohio State University Research Foundation
    Inventors: Richard H. Reuning, James Hui, Theresa A. Shepard, Richard A. Sams