Abstract: The present disclosure describes devices, systems, and methods for intravascularly delivering an implantable device to a targeted anatomical site such as the mitral annulus. A delivery system includes a delivery member coupled to a handle assembly and extending distally from the handle assembly. A delivery catheter is concentrically positioned within an outer member and configured to advance the intravascular device relative to the outer member. The delivery catheter includes a distal can structure configured to house at least a portion of the intravascular device in a compressed, pre-deployed position.

Abstract: Implantable medical devices have zones of high in vivo stability that are adjacent to zones of relatively low in vivo stability, so that when these medical devices are implanted into a host, the zones of low in vivo stability degrade first and allow the formation of independent segments of relatively intact high in vivo stability bands that are sufficiently small that they may pass from the host in a non-harmful manner.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting an ATXN2 gene, as well as methods of inhibiting expression of an ATXN2 gene and methods of treating subjects having an ATXN2-associated neurodegenerative disease or disorder, e.g., SCAs and ALS, using such dsRNAi agents and compositions.

Abstract: The present disclosure describes devices, systems, and methods for intravascularly delivering an implantable device to a targeted anatomical site such as the mitral annulus. A delivery system includes a delivery member coupled to a handle assembly and extending distally from the handle assembly. A delivery catheter is concentrically positioned within an outer member and configured to advance the intravascular device relative to the outer member. The delivery catheter includes a distal can structure configured to house at least a portion of the intravascular device in a compressed, pre-deployed position.

Abstract: Implantable medical devices have zones of high in vivo stability that are adjacent to zones of relatively low in vivo stability, so that when these medical devices are implanted into a host, the zones of low in vivo stability degrade first and allow the formation of independent segments of relatively intact high in vivo stability bands that are sufficiently small that they may pass from the host in a non-harmful manner.

Abstract: Porous and microporous parts prepared by additive manufacturing as disclosed herein are useful in medical and non-medical applications. The parts are prepared from a composition containing both a solvent soluble component and a solvent insoluble component. After a part is printed by an additive manufacturing process it is exposed to solvent to extract solvent soluble component away front the printed part, resulting in a part having surface cavities.

Abstract: A bone cement pressuriser (50) comprising a pressuriser head. The pressuriser head has a first side (51) coupled to or configured to couple to an end of a pressuriser handle and a second side (52) configured to transfer pressure to bone cement in a bone cavity. The second side of the pressuriser head is defined by a first, convex curved surface (53) and a second surface (54) forming a ring surrounding the first surface and extending radially beyond the first surface. A method of pressurising bone cement using the bone cement pressuriser is also disclosed. The first surface is configured to pressurise bone cement within a bone cavity and the second surface is configured to both pressurise bone cement within the bone cavity and to seal about the periphery of the bone cavity.

Abstract: Porous and microporous parts prepared by additive manufacturing as disclosed herein are useful in medical and non-medical applications. The parts are prepared from a composition containing both a solvent soluble component and a solvent insoluble component. After a part is printed by an additive manufacturing process it is exposed to solvent to extract solvent soluble component away from the printed part, resulting in a part having surface cavities.

Abstract: Porous and microporous parts prepared by additive manufacturing as disclosed herein are useful in medical and non-medical applications. The parts are prepared from a composition containing both a solvent soluble component and a solvent insoluble component. After a part is printed by an additive manufacturing process it is exposed to solvent to extract solvent soluble component away from the printed part, resulting in a part having surface cavities.

Abstract: Porous and microporous parts prepared by additive manufacturing as disclosed herein are useful in medical and non-medical applications. The parts are prepared from a composition containing both a solvent soluble component and a solvent insoluble component. After a part is printed by an additive manufacturing process it is exposed to solvent to extract solvent soluble component away from the printed part, resulting in a part having surface cavities.

Abstract: Implantable medical devices have zones of high in vivo stability that are adjacent to zones of relatively low in vivo stability, so that when these medical devices are implanted into a host, the zones of low in vivo stability degrade first and allow the formation of independent segments of relatively intact high in vivo stability bands that are sufficiently small that they may pass from the host in a non-harmful manner.

Abstract: Porous and microporous parts prepared by additive manufacturing as disclosed herein are useful in medical and non-medical applications. The parts are prepared from a composition containing both a solvent soluble component and a solvent insoluble component. After a part is printed by an additive manufacturing process it is exposed to solvent to extract solvent soluble component away from the printed part, resulting in a part having surface cavities.

Abstract: An electronic trading system implements a display price that guarantees a minimum available quantity for trade. The electronic trading system determines a quantity of financial instruments available at various prices for incoming orders. A display bid price and display offer price are determined so that the quantity available at the display prices exceeds a display quantity threshold. The electronic trading system receives orders designated fast and slow. Fast orders are used for large, rapid trades at known prices. Slow orders trade with a delay for a price improvement auction. Orders meeting a minimum order quantity threshold may participate in an auction for incoming orders that offers price improvement to the execution price of aggressively priced orders. The electronic trading system implements risk management measures based on order size and percentage filled for individual trades and series of trades. The electronic trading system supports orders having multiple legs.

Abstract: An electronic trading system implements a display price that guarantees a minimum available quantity for trade. The electronic trading system determines a quantity of financial instruments available at various prices for incoming orders. A display bid price and display offer price are determined so that the quantity available at the display prices exceeds a display quantity threshold. The electronic trading system receives orders designated fast and slow. Fast orders are used for large, rapid trades at known prices. Slow orders trade with a delay for a price improvement auction. Orders meeting a minimum order quantity threshold may participate in an auction for incoming orders that offers price improvement to the execution price of aggressively priced orders. The electronic trading system implements risk management measures based on order size and percentage filled for individual trades and series of trades. The electronic trading system supports orders having multiple legs.

Abstract: An electronic trading system implements a display price that guarantees a minimum available quantity for trade. The electronic trading system determines a quantity of financial instruments available at various prices for incoming orders. A display bid price and display offer price are determined so that the quantity available at the display prices exceeds a display quantity threshold. The electronic trading system receives orders designated fast and slow. Fast orders are used for large, rapid trades at known prices. Slow orders trade with a delay for a price improvement auction. Orders meeting a minimum order quantity threshold may participate in an auction for incoming orders that offers price improvement to the execution price of aggressively priced orders. The electronic trading system implements risk management measures based on order size and percentage filled for individual trades and series of trades. The electronic trading system supports orders having multiple legs.

Abstract: An electronic trading system implements a display price that guarantees a minimum available quantity for trade. The electronic trading system determines a quantity of financial instruments available at various prices for incoming orders. A display bid price and display offer price are determined so that the quantity available at the display prices exceeds a display quantity threshold. The electronic trading system receives orders designated fast and slow. Fast orders are used for large, rapid trades at known prices. Slow orders trade with a delay for a price improvement auction. Orders meeting a minimum order quantity threshold may participate in an auction for incoming orders that offers price improvement to the execution price of aggressively priced orders. The electronic trading system implements risk management measures based on order size and percentage filled for individual trades and series of trades. The electronic trading system supports orders having multiple legs.

Abstract: An electronic trading system implements a display price that guarantees a minimum available quantity for trade. The electronic trading system determines a quantity of financial instruments available at various prices for incoming orders. A display bid price and display offer price are determined so that the quantity available at the display prices exceeds a display quantity threshold. The electronic trading system receives orders designated fast and slow. Fast orders are used for large, rapid trades at known prices. Slow orders trade with a delay for a price improvement auction. Orders meeting a minimum order quantity threshold may participate in an auction for incoming orders that offers price improvement to the execution price of aggressively priced orders. The electronic trading system implements risk management measures based on order size and percentage filled for individual trades and series of trades. The electronic trading system supports orders having multiple legs.

Abstract: This application relates to systems and methods for advertising in retail environments through the use of video displays that are disposed on retail shelving near target products. In some instances, the video display system may comprise a head-end cabinet that is located remote to the video displays. The head-end cabinet may communicate with at least one tail-end box. In turn, each tail-end box may communicate with at least one line-driver box. The line-driver box may communicate with a fin box that sends signal to the video display. The video displays may be vertically and laterally located on the shelving to catch consumer attention and be easily circumnavigated. For example, the video displays may not be located in an end-of-aisle exclusion zone located at each end of a section of shelving. Similarly, no each video display in an aisle may be a minimum distance from another video display.

Abstract: A method of forming an air-tight scal between two pieces of glass is described. It comprises the steps of: (a) introducing a layer of indium or indium alloy between opposing surfaces of the glass pieces; and (b) heating the indium or indium alloy layers and the glass pieces, preferably under vacuum, to a temperature, generally around or below 220° C., to melt the layers to form the seal between the pieces. The method is suitable to form a relatively small air-type seal between two glass panes or sheets, and is particularly suitable for the formation of evacuated double glazing units. Optionally, an additional metal layer is located between the indium or indium alloy layers.