Abstract: A potassium salt useful in the production of certain N-substituted alkyl or arylalkyl thionitroethenamines is produced by the reaction of the dipotassium salt of a 2-nitrodithio aliphatic acid such as 2-nitrodithio acetic acid with branched chain primary alkylamines, secondary alkylamines, arylalkylamines or heterocyclic alkylamines such as dimethylamine, pinacolylamine, benzylamine or piperonylamine, thereby converting one only of the KS-groups to an alkylamine group. The resulting monopotassium salt may be alkylated or arylalkylated to produce an N-substituted alkyl or arylalkyl thionitroethenamine. This compound may be reacted with a suitable amine to produce compounds containing the pharmaceutically active grouping --NHC(.dbd.CHNO.sub.2)NHX, wherein X represents an alkyl, arylalkyl or heterocyclic alkyl group.

Abstract: According to the invention, there is provided a process for the preparation of an aminoalkyl p-hydroxyphenyl ketone comprising reacting phenol with a nitrile, in the presence of a Lewis acid catalyst, to cause condensation thereof, the process being characterised in that the reaction is carried out in a medium comprising a nitroalkane solvent for the reactants.

Abstract: A potassium salt useful in the production of N-substituted-1-alkylthio-2-nitroethenamines is produced by the reaction of the dipotassium salt of nitrodithioacetic acid with certain straight chain alkylamines, thereby converting only one of the KS-groups to an alkylamine group. The resulting monopotassium salt may be alkylated to produce the required N-substituted-1-alkylthio compound which may be reacted with a suitable amine to produce the histamine H.sub.2 -antagonist ranitidine.

Abstract: 3-Hydroxy-3-(2-methyl-5-pyridyl)-propionic acid alkyl esters which, as intermediate products that can be industrially produced in a simple manner, can be used for the production of 2-methylpyridine-5-propionic acid alkyl ester.

Abstract: 3-Hydroxy-3-(2-methyl-5-pyridyl)-propionic acid alkyl esters which, as intermediate products that can be industrially produced in a simple manner, can be used for the production of 2-methylpyridine-5-propionic acid alkyl ester.

Abstract: A process for the production of 6-methylnicotinic acid ester by oxidation of 2-methyl-5-ethylpyridine at an elevated temperature. Specifically, 2-methyl-5-ethylpyridine is mixed while cooling with at least a molar quantity of sulfuric acid. The mixture is heated to a temperature of 140.degree. to 225.degree. C. At least 3 moles of nitric acid per mole of educt is added to the heated mixture in such a way that water and/or diluted nitric acid are continuously distilled off. The distillation after addition of the nitric acid which is needed for the oxidation is continued until all of the water and all of the nitric acid are removed. Subsequently the reaction mixture is mixed with an alcohol and the alcoholic reaction mixture is heated until the acids contained in the reaction mixture are esterified. The 6-methylnicotinic acid ester is isolated from the ester mixture.

Abstract: Method for the production of 3-picoline wherein a first educt, consisting of at least one acetaldehydeacetal with or without acetaldehyde and/or crotonaldehyde, is reacted with a second educt, consisting of at least one formaldehydeacetal and/or hexamethylenetetramine with or without formaldehyde, in a liquid, aqueous phase at a temperature of 180.degree. to 280.degree. C. in a closed vessel. The reaction is conducted in the presence of ammonia and/or ammonium ions. The reaction is also conducted in the presence of an anion or anions of an inorganic and/or organic acid or acids, which at 20.degree. C. have an acid dissociation constant of 10.sup.6 to 10.sup.-12.

Abstract: Process for the production of 3-picoline wherein a first educt, consisting of acetaldehyde and/or at least one acetaldehydeacetal and/or crotonaldehyde, is reacted with a second educt, consisting of formaldehyde and/or at least one formaldehydeacetal and/or hexamethylenetetramine, in a liquid, aqueous phase at a temperature of 180.degree. to 280.degree. C. in a closed vessel. The reaction is conducted in the presence of ammonia and/or ammonium ions. The reaction is also conducted in the presence of at least one water-soluble alkali metal salt of an inorganic and/or organic acid or acids which provides an anion or anions of an inorganic and/or organic acid or acids, which at 20.degree. C. have an acid dissociation constant of 10.sup.6 to 10.sup.-12.

Abstract: Process for the production of 3,5-dialkylpyridines. An aldehyde having the formula R--CH.sub.2 --CHO, wherein R is a straight-chained or branched alkyl radical having 1 to 6 carbon atoms, and/or an acetal of such aldehyde is reacted with formaldehyde and/or hexamethylene tetramine and/or a formaldehyde acetal and/or a polymer of formaldehyde in liquid or aqueous phase at a temperature of 180.degree. to 280.degree. C. in a closed vessel in the presence of ammonia and/or ammonium ions and in the presence of anions of an inorganic and/or an organic acid, both of which at 20.degree. C. have an acid dissociation constant of 10.sup.6 to 10.sup.-12.

Abstract: Process for the production of 3-picoline. Acrolein or a mixture of acrolein and formaldehyde is reacted in a liquid aqueous phase at a temperature of 180.degree. to 280.degree. C. in a closed vessel. Ammonia and/or ammonium ions, and anions of an inorganic or organic acid, which has an acid dissociation constant of 10.sup.6 to 10.sup.-12, at 20.degree. C., are also present.