Patents by Inventor James I. Hembre
James I. Hembre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170183299Abstract: A process for preparing guanidino-functional, free radically polymerizable compounds comprises (a) combining (1) an amine compound comprising (i) at least one primary aliphatic amino group and (ii) at least one secondary aliphatic amino group, primary aromatic amino group, or secondary aromatic amino group, and (2) a guanylating agent; (b) allowing or inducing reaction of the amine compound and the guanylating agent to form a guanylated amine compound; (c) combining (1) the guanylated amine compound, and (2) a reactive monomer comprising (i) at least one ethylenically unsaturated group and (ii) at least one group that is reactive with an amino group; and (d) allowing or inducing reaction of the guanylated amine compound and the reactive monomer to form a guanidino-functional, free radically polymerizable compound.Type: ApplicationFiled: March 15, 2017Publication date: June 29, 2017Inventors: Jerald K. Rasmussen, George W. Griesgraber, James I. Hembre
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Publication number: 20170165617Abstract: Guanidinyl ligand-functionalized polymers, methods of making the same, and substrates bearing a grafted coating of the ligand-functional polymers are described. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, endotoxins and proteins, at pH's near or below the pI's of the biomaterials.Type: ApplicationFiled: February 28, 2017Publication date: June 15, 2017Inventors: Catherine A. Bothof, George W. Griesgraber, James I. Hembre, Jerald K. Rasmussen
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Patent number: 9670149Abstract: A process for preparing guanidino-functional, free radically polymerizable compounds comprises (a) combining (1) an amine compound comprising (i) at least one primary aliphatic amino group and (ii) at least one secondary aliphatic amino group, primary aromatic amino group, or secondary aromatic amino group, and (2) a guanylating agent; (b) allowing or inducing reaction of the amine compound and the guanylating agent to form a guanylated amine compound; (c) combining (1) the guanylated amine compound, and (2) a reactive monomer comprising (i) at least one ethylenically unsaturated group and (ii) at least one group that is reactive with an amino group; and (d) allowing or inducing reaction of the guanylated amine compound and the reactive monomer to form a guanidino-functional, free radically polymerizable compound.Type: GrantFiled: June 12, 2014Date of Patent: June 6, 2017Assignee: 3M Innovative Properties CompanyInventors: Jerald K. Rasmussen, George W. Griesgraber, James I. Hembre
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Patent number: 9616394Abstract: Guanidinyl ligand-functionalized polymers, methods of making the same, and substrates bearing a grafted coating of the ligand-functional polymers are described. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, endotoxins and proteins, at pH's near or below the pI's of the biomaterials.Type: GrantFiled: May 23, 2013Date of Patent: April 11, 2017Assignee: 3M Innovative Properties CompanyInventors: Catherine A. Bothof, George W. Griesgraber, James I. Hembre, Jerald K. Rasmussen
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Publication number: 20160231208Abstract: An article that can be used for biomaterial capture comprises (a) a porous substrate; and (b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.Type: ApplicationFiled: September 25, 2014Publication date: August 11, 2016Inventors: Jerald K. Rasmussen, Catherine A. Bothof, George W. Griesgraber, Semra Colak Atan, James I. Hembre, Robert T. Fitzsimons, JR.
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Publication number: 20160152662Abstract: A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials.Type: ApplicationFiled: February 8, 2016Publication date: June 2, 2016Inventors: Jerald K. Rasmussen, Catherine A. Bothof, Kannan Seshadri, James I. Hembre, Robert T. Fitzsimons, JR., George W. Griesgraber, Yi He
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Publication number: 20160096802Abstract: A process for preparing guanidino-functional, free radically polymerizable compounds comprises (a) combining (1) an amine compound comprising (i) at least one primary aliphatic amino group and (ii) at least one secondary aliphatic amino group, primary aromatic amino group, or secondary aromatic amino group, and (2) a guanylating agent; (b) allowing or inducing reaction of the amine compound and the guanylating agent to form a guanylated amine compound; (c) combining (1) the guanylated amine compound, and (2) a reactive monomer comprising (i) at least one ethylenically unsaturated group and (ii) at least one group that is reactive with an amino group; and (d) allowing or inducing reaction of the guanylated amine compound and the reactive monomer to form a guanidino-functional, free radically polymerizable compound.Type: ApplicationFiled: June 12, 2014Publication date: April 7, 2016Inventors: Jerald K. Rasmussen, George W. Griesgraber, James I. Hembre
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Patent number: 9272246Abstract: A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials.Type: GrantFiled: January 19, 2012Date of Patent: March 1, 2016Assignee: 3M INNOVATIVE PROPERTIES COMPANYInventors: Jerald K. Rasmussen, Catherine A. Bothof, Kannan Seshadri, James I. Hembre, Robert T. Fitzsimons, Jr., George W. Griesgraber, Yi He
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Patent number: 9056316Abstract: Semi-interpenetrating polymeric networks are described. More specifically, the semi-interpenetrating polymeric networks include at least two polymers that are closely associated. The first polymer is an ionic polymer that is not crosslinked. The second polymer is a cross-linked polymer that can be either another ionic polymer or a non-ionic polymer. Methods of making the semi-interpenetrating polymeric networks, articles containing the semi-interpenetrating polymeric networks, and methods of using the semi-interpenetrating polymeric networks are also described. The semi-interpenetrating polymeric networks can function as ion exchange resins.Type: GrantFiled: June 17, 2011Date of Patent: June 16, 2015Assignee: 3M INNOVATIVE PROPERTIES COMPANYInventors: Del R. Lawson, James I. Hembre, Jerald K. Rasmussen, Catherine A. Bothof, Kannan Seshadri, Robert T. Fitzsimons, Jr., Andrew W. Rabins, Taib K. Ansera
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Publication number: 20150136698Abstract: Guanidinyl ligand-functionalized polymers, methods of making the same, and substrates bearing a grafted coating of the ligand-functional polymers are described. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, endotoxins and proteins, at pH's near or below the pI's of the biomaterials.Type: ApplicationFiled: May 23, 2013Publication date: May 21, 2015Inventors: Catherine A. Bothof, George W. Griesgraber, James I. Hembre, Jerald K. Rasmussen
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Publication number: 20140193875Abstract: Porous polymeric resins, reaction mixtures and methods that can be used to prepare the porous polymeric resins, and uses of the porous polymeric resin are described. More specifically, the polymeric resins typically have a hierarchical porous structure plus reactive groups that can be used to interact with or react with a variety of different target compounds. The reactive groups can be selected from an acidic group or a salt thereof, an amino group or salt thereof, a hydroxyl group, an azlactone group, a glycidyl group, or a combination thereof.Type: ApplicationFiled: March 11, 2014Publication date: July 10, 2014Applicant: 3M INNOVATIVE PROPERTIES COMPANYInventors: Peter D. Wickert, Simon K. Shannon, Kannan Seshadri, Jerald K. Rasmussen, James I. Hembre, Robert T. Fitzsimons, JR.
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Patent number: 8710111Abstract: Porous polymeric resins, reaction mixtures and methods that can be used to prepare the porous polymeric resins, and uses of the porous polymeric resin are described. More specifically, the polymeric resins typically have a hierarchical porous structure plus reactive groups that can be used to interact with or react with a variety of different target compounds. The reactive groups can be selected from an acidic group or a salt thereof, an amino group or salt thereof, a hydroxyl group, an azlactone group, a glycidyl group, or a combination thereof.Type: GrantFiled: November 5, 2008Date of Patent: April 29, 2014Assignee: 3M Innovative Properties CompanyInventors: Peter D. Wickert, Simon K. Shannon, Kannan Seshadri, Jerald K. Rasmussen, James I. Hembre, Robert T. Fitzsimons, Jr.
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Patent number: 8435776Abstract: A method of separating a target biological species from a fluid is disclosed comprising contacting the fluid with a ligand-functionalized polymer comprising: a water soluble or water dispersible aminopolymer functionalized with guanidinyl groups; whereby a complex comprising the functionalized substrate and the target biological species is formed.Type: GrantFiled: February 14, 2011Date of Patent: May 7, 2013Assignee: 3M Innovative Properties CompanyInventors: Jerald K. Rasmussen, Kannan Seshadri, Robert T. Fitzsimons, Jr., James I. Hembre, Catherine A. Bothof, Erin A. Satterwhite, George W. Griesgraber, Yi He, Louis C. Haddad
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Publication number: 20130090397Abstract: Semi-interpenetrating polymeric networks are described. More specifically, the semi-interpenetrating polymeric networks include at least two polymers that are closely associated. The first polymer is an ionic polymer that is not crosslinked. The second polymer is a cross-linked polymer that can be either another ionic polymer or a non-ionic polymer. Methods of making the semi-interpenetrating polymeric networks, articles containing the semi-interpenetrating polymeric networks, and methods of using the semi-interpenetrating polymeric networks are also described. The semi-interpenetrating polymeric networks can function as ion exchange resins.Type: ApplicationFiled: June 17, 2011Publication date: April 11, 2013Applicant: 3M INNOVATIVE PROPERTIES COMPANYInventors: Del R. Lawson, James I. Hembre, Jerald K. Rasmussen, Catherine A. Bothof, Kannan Seshadri, Robert T. Fitzsimons, JR., Andrew W. Rabins, Taib K. Ansera
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Patent number: 8377672Abstract: Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.Type: GrantFiled: January 7, 2011Date of Patent: February 19, 2013Assignee: 3M Innovative Properties CompanyInventors: Jerald K. Rasmussen, Catherine A. Bothof, Kannan Seshadri, Erin A. Satterwhite, Robert T. Fitzsimons, James I. Hembre, Mahfuza B. Ali
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Patent number: 8349906Abstract: Methods of making macroporous cation exchange resins are described. The macroporous cation exchange resins are in the form of particles such as beads that contain a hydrophilic, crosslinked, (meth)acrylic-type polymeric material. The macroporous cation exchange resins are prepared using an inverse suspension polymerization process in the presence of a water soluble, organic, aliphatic porogen having at least three hydroxy groups.Type: GrantFiled: January 20, 2010Date of Patent: January 8, 2013Assignee: 3M Innovative Properties CompanyInventors: Jerald K. Rasmussen, Robert T. Fitzsimons, Jr., Kannan Seshadri, Simon K. Shannon, Peter D. Wickert, James I. Hembre
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Patent number: 8338497Abstract: Methods of making macroporous anion exchange resins are described. The macroporous anion exchange resins are in the form of particles such as beads that contain a hydrophilic, crosslinked, (meth)acrylic-type polymeric material. Additionally, methods of purifying a negatively charged material using the macroporous anion exchange resins, methods of making chromatographic columns that contain the macroporous anion exchange resins, methods of making filter elements that contain the macroporous anion exchange resins, and methods of making porous composite materials that contain the macroporous anion exchange resins are described.Type: GrantFiled: January 18, 2010Date of Patent: December 25, 2012Assignee: 3M Innovative Properties CompanyInventors: Jerald K. Rasmussen, Robert T. Fitzsimons, Jr., Kannan Seshadri, Simon K. Shannon, Peter D. Wickert, James I. Hembre
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Patent number: 8338496Abstract: Methods of making macroporous cation exchange resins are described. The macroporous cation exchange resins are in the form of particles such as beads that contain a hydrophilic, crosslinked, (meth)acrylic-type polymeric material. Additionally, methods of purifying a positively charged material using the macroporous cation exchange resins, methods of making chromatographic columns that contain the macroporous cation exchange resins, methods of making filter elements that contain the macroporous cation exchange resins, and methods of making porous composite materials that contain the macroporous cation exchange resins are described.Type: GrantFiled: January 15, 2010Date of Patent: December 25, 2012Assignee: 3M Innovative Properties CompanyInventors: Jerald K. Rasmussen, Robert T. Fitzsimons, Jr., Kannan Seshadri, Simon K. Shannon, Peter D. Wickert, James I. Hembre
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Publication number: 20120252091Abstract: A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials.Type: ApplicationFiled: January 19, 2012Publication date: October 4, 2012Inventors: Jerald K. Rasmussen, Catherine A. Bothof, Kannan Seshadri, James I. Hembre, Robert T. Fitzsimons, JR., George W. Griesgraber, Yi He
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HYDROPHOBIC MONOMERS, HYDROPHOBICALLY-DERIVATIZED SUPPORTS, AND METHODS OF MAKING AND USING THE SAME
Publication number: 20120039920Abstract: A composition is disclosed comprising a hydrophobic monomer having the structure: CH2?CR4C(O)NHC(R1R1)(C(R1R1))nC(O)XR3 wherein n is an integer of 0 or 1; R1 is independently selected from at least one of: a hydrogen atom, alkyls aryls, and alkylaryls, wherein the alkyls, aryls, and alkylaryls have a total of 10 carbon atoms or less; R3 is a hydrophobic group selected from at least one of: alkyls, aryls, alkylaryls and ethers, wherein the alkyls, aryls, alkylaryls and ethers have a total number of carbon atoms ranging from 4 to 30; R4 H or CH3; X is O or NH. In some embodiments the hydrophobic monomer is derived from an amine or an alcohol (HXR3) that has a hydrophilicity index of 25 or less. A polymerizable composition comprising the hydrophobic monomer is disclosed, which optionally may comprise a cross-linking monomer and/or a non-cross-linking monomer.Type: ApplicationFiled: March 19, 2010Publication date: February 16, 2012Inventors: Jerald K. Rasmussen, Cary A. Kipke, James I. Hembre, Peter D. Wickert