Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A device for sensing the input shaft speed of an automotive automatic transmission that is driven by the engine through the fluid coupling of a torque converter. The speed sensor device includes circumferentially spaced markings about the transmission input shaft and a speed sensor that is placed at close proximity to the circumferentially spaced markings through a hole in the torque converter stator shaft. An electronic control unit (ECU) analyzes the sensor output signal and in the case of an active speed sensor it also functions as its power source. During vehicle operation, the transmission input shaft rotates the target wheel in front of the speed sensor causing modulation of its output signal. The electronic control unit analyzes the signal modulation and calculates the input shaft rotational speed. A variety of sensor/target-wheel options and sensor mounting techniques could be used depending on the application constraints.

Abstract: A device for sensing the input shaft speed of an automotive automatic transmission that is driven by the engine through the fluid coupling of a torque converter. The speed sensor device includes circumferentially spaced markings about the transmission input shaft and a speed sensor that is placed at close proximity to the circumferentially spaced markings through a hole in the torque converter stator shaft. An electronic control unit (ECU) analyzes the sensor output signal and in the case of an active speed sensor it also functions as its power source. During vehicle operation, the transmission input shaft rotates the target wheel in front of the speed sensor causing modulation of its output signal. The electronic control unit analyzes the signal modulation and calculates the input shaft rotational speed. A variety of sensor/target-wheel options and sensor mounting techniques could be used depending on the application constraints.

Abstract: The leaching chamber endplate including snap connectors, pipe stops, pipe scores, drill guide(s), and a barrier that facilitates enhanced engagement between the endplate and leaching chamber. This endplate is preferably formed using a blow molding process that forms, in situ, the endplate, including the snap connectors and the barrier.

Abstract: The leaching chamber endplate ha snap connectors, pipe stops, pipe scores, drill guide(s), and a barrier which facilitates enhanced engagement between the endplate and leaching chamber. This endplate is preferably formed using a blow molding process which forms, insitu, the endplate, including the snap connectors and the barrier.

Abstract: A lighting device (32) is provided to illuminate indicia (18) of an EXIT sign (10) having a sign housing (12) defining an enclosure (22) therein and having a primary electrical power source. The lighting device is provided with a reflector (40) having a shallow V-shaped contour (43,44,45) defining a centrally located valley in the reflector and a source of illumination (42) positioned in the valley of the reflector and powered by the primary power source, the source of illumination including two rows of LEDs (65), each row having a plurality of LEDs, and the rows being separated from one another and positioned on either side of the valley. The LEDs are positioned on either side of the valley (44,45) a sufficient distance from the valley to illuminate the edges of the sign parallel to the valley while preventing areas within the valley from having dark and/or unilluminated spots. The rows of LEDs are mounted on opposite edges of a printed circuit board (70) positioned in the valley of the reflector.