Patents by Inventor James J. Childs

James J. Childs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10413542
    Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: September 17, 2019
    Assignees: Buck Institute for Research on Aging, Unity Biotechnology, Inc., Mayo Foundation for Medical Education and Research
    Inventors: Remi-Martin Laberge, Nathaniel David, Alain Philippe Vasserot, Darren J. Baker, Bennett G. Childs, James L. Kirkland, Tamar Tchkonia, Jan M. A. van Deursen, Yi Zhu
  • Patent number: 10382729
    Abstract: Methods, apparatuses, and techniques for security and/or automation systems are described. In one embodiment, the method may include receiving a call initiation instruction at a video monitoring component of a home automation system. The method may further include analyzing the call initiation instruction, and communicating a call request from the video monitoring component of the home automation system to a first remote user based at least in part on the received call initiation instruction.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: August 13, 2019
    Assignee: Vivint, Inc.
    Inventors: Michael D. Child, Matthew Mahar, Matthew J. Eyring, Clint Huson Gordon-Carroll, Jeremy Bruce Warren, James Ellis Nye, Jefferson Huhta Lyman, Michelle Zundel
  • Patent number: 10328073
    Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: June 25, 2019
    Assignees: Unity Biotechnology, Inc., Buck Institute for Research on Aging, Mayo Foundation for Medical Education and Research
    Inventors: Remi-Martin Laberge, Judith Campisi, Marco Demaria, Nathaniel David, Alain Philippe Vasserot, James L. Kirkland, Tamar Tchkonia, Yi Zhu, Darren J. Baker, Bennett G. Childs, Jan M. A. van Deursen
  • Patent number: 10328058
    Abstract: Foamy macrophages with senescence markers accumulate in the subendothelial space at the onset of atherosclerosis where they drive pathology by increasing expression of key atherogenic and inflammatory cytokines and chemokines. In advanced lesions, senescent cells promote features of plaque instability, including elastic fiber degradation and fibrous cap thinning, by heightening metalloprotease production. This invention provides methods and materials for treating arthritis by removing senescent cells in or around atherosclerotic plaques, thereby stabilizing the plaques, inhibiting rupture of the plaques and pathological sequelae that manifest as coronary artery disease.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: June 25, 2019
    Assignees: Mayo Foundation for Medical Education and Research, Unity Biotechnology, Inc., Buck Institute for Research on Aging
    Inventors: Darren J. Baker, Marco Demaria, Albert Davalos, Bennett G. Childs, Jan M. A. van Deursen, James L. Kirkland, Tamar Tchkonia, Yi Zhu, Nathaniel David, Remi-Martin Laberge, Judith Campisi
  • Publication number: 20140127137
    Abstract: Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
    Type: Application
    Filed: June 17, 2013
    Publication date: May 8, 2014
    Applicant: Cercacor Laboratories, Inc
    Inventors: Emile M. Bellott, Dongsheng Bu, James J. Childs, Christopher Lambert, Hubert A. Nienaber, Shirley J. Shi, Zhaolin Wang, Jerome J. Workman, Alex R. Zelenchuk
  • Publication number: 20140074133
    Abstract: Methods, systems, and apparatus for hair treatment are disclosed which include applying treatment radiation to a skin treatment area and/or to one or more hairs to deposit energy in one or more hairs so as to modify the structure (e.g., the mechanical structure and/or the chemical structure of at least a portion of the hair(s)). The applied radiation can modify at least a portion of the hair (e.g., the hair tip) to make the hair less capable of re-entering the skin. Specifically, the proposed technique is directed to decreasing stiffness of at least portion of a hair through diminishing its flexural modulus as well as increasing the bend radius of its sharpest point. The methods and apparatus can treat and/or prevent pseudofolliculitis barbae (PFB) in the treatment area.
    Type: Application
    Filed: March 7, 2013
    Publication date: March 13, 2014
    Applicant: PALOMAR MEDICAL TECHNOLOGIES, INC.
    Inventors: Gregory B. Altshuler, James J. Childs, Ilya Yaroslavsky, Henry H. Zenzie
  • Patent number: 8466286
    Abstract: Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
    Type: Grant
    Filed: August 22, 2011
    Date of Patent: June 18, 2013
    Assignee: Cercacor Laboratories, Inc.
    Inventors: Emile M. Bellott, Dongsheng Bu, James J. Childs, Christopher Lambert, Hubert A. Nienaber, Shirley J. Shi, Zhaolin Wang, Jerome J. Workman, Alex R. Zelenchuk
  • Publication number: 20120116271
    Abstract: A method and apparatus are provided for treating connective tissue. The method and apparatus can be used for treating and/or reducing the appearance of cellulite.
    Type: Application
    Filed: December 13, 2011
    Publication date: May 10, 2012
    Applicant: PALOMAR MEDICAL TECHNOLOGIES, INC.
    Inventors: Joseph P. Caruso, Andrei V. Belikov, Gregory B. Altshuler, James J. Childs
  • Publication number: 20120052018
    Abstract: Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
    Type: Application
    Filed: August 22, 2011
    Publication date: March 1, 2012
    Applicant: Masimo Laboratories, Inc.
    Inventors: Emile M. Bellott, Dongsheng Bu, James J. Childs, Christopher Lambert, Hubert A. Nienaber, Shirley J. Shi, Zhaolin Wang, Jerome J. Workman, Alex R. Zelenchuk
  • Patent number: 8029765
    Abstract: Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: October 4, 2011
    Assignee: Masimo Laboratories, Inc.
    Inventors: Emile M. Bellott, Dongsheng Bu, James J. Childs, Christopher Lambert, Hubert A. Nienaber, Shirley J. Shi, Zhaolin Wang, Jerome J. Workman, Alex R. Zelenchuk
  • Patent number: 8008088
    Abstract: Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
    Type: Grant
    Filed: June 26, 2006
    Date of Patent: August 30, 2011
    Assignee: Masimo Laboratories, Inc.
    Inventors: Emile M. Bellott, Dongsheng Bu, James J. Childs, Christopher Lambert, Hubert A. Nienaber, Shirley J. Shi, Zhaolin Wang, Jerome J. Workman, Alex R. Zelenchuk
  • Publication number: 20100286673
    Abstract: Devices and methods of treatment of tissue, such as skin tissue, with electromagnetic radiation (EMR) are disclosed that employ local deformation of tissue in small areas. Devices and methods employing local deformation are used to produce fractional lattices of EMR-treated islets in tissue for application including hair growth management.
    Type: Application
    Filed: April 5, 2010
    Publication date: November 11, 2010
    Applicant: PALOMAR MEDICAL TECHNOLOGIES, INC.
    Inventors: Gregory B. Altshuler, Andrei Belikov, James J. Childs, Andrei V. Erofeev, Ilya Yaroslavsky, Henry H. Zenzie
  • Publication number: 20100145321
    Abstract: Methods of treatment of tissue with electromagnetic radiation (EMR) to produce lattices of EMR-treated islets in the tissue are disclosed. Also disclosed are devices and systems for producing lattices of EMR-treated islets in tissue, and cosmetic and medical applications of such devices and systems.
    Type: Application
    Filed: November 25, 2009
    Publication date: June 10, 2010
    Applicant: PALOMAR MEDICAL TECHNOLOGIES, INC.
    Inventors: Gregory B. Altshuler, Ilya Yaroslavsky, Andrei V. Erofeev, David Tabatadze, Mikhail Z. Smirnov, James J. Childs
  • Publication number: 20090004108
    Abstract: Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
    Type: Application
    Filed: December 23, 2004
    Publication date: January 1, 2009
    Applicant: Masimo Laboratories, Inc.
    Inventors: Emile M. Bellott, Dongsheng Bu, James J. Childs, Christopher Lambert, Hubert A. Nienaber, Shirley J. Shi, Zhaolin Wang, Jerome J. Workman, Alex R. Zelenchuk
  • Patent number: 6219132
    Abstract: A method of performing analysis of samples having turbidity and/or high absorbance is disclosed. The analysis utilizes information from multiple factors, which affect transmittance or absorbance. These factors include: absorbance as measured in a non-turbid sample, scattering losses due to particles and limitations of the measurement device as measured in a non-absorbing sample, additional scattering losses due to sample absorbance, variable path length effects due to the sample, variable path length effects due to the measurement device, and additional nonlinear effects. By taking into account additional factors that affect transmittance or absorbance, a more accurate analysis is achieved.
    Type: Grant
    Filed: September 24, 1998
    Date of Patent: April 17, 2001
    Assignee: Bayer Corporation
    Inventors: Ronald S. Scharlack, James J. Childs
  • Patent number: 6172744
    Abstract: A method for analysis of samples having turbidity and/or high absorption is disclosed. The analysis incorporates several factors that affect transmittance or absorption. These factors may include: absorption as measured in a non-turbid sample, scattering losses due to particles and limitations of the measurement device as measured in a non-absorbing sample, additional scattering losses due to sample absorption, variable path length effects due to the sample, and variable path length effects due to the measurement device. By taking into account additional factors that affect transmittance or absorption, a more accurate analysis is achieved.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: January 9, 2001
    Assignee: Bayer Corporation
    Inventors: Ronald S. Scharlack, James J. Childs
  • Patent number: 5859867
    Abstract: In a single-atom microlaser, a pair of opposed reflectors define a high-finesse or "high-Q" optical cavity therebetween. A source delivers a stream of multiple-energy-level atoms or particles into the cavity. Each individual atom in the stream is excited by a pump from a lower energy level to an upper energy level before injection into the cavity. The cavity resonance frequency is substantially matched to the frequency of a photon emitted by each atom as it enters the cavity. The photon is emitted due to a transition in energy between the upper level and lower level of each atom. In this manner, upon entry of a sequence of individual atoms into the cavity for example, the average number of photons resonating in the cavity exceeds one and the average number of atoms in the cavity is less than one. The photons are sustained in the high-Q cavity for a long enough time period such that the photon field interacts with the next atom in the stream.
    Type: Grant
    Filed: November 30, 1995
    Date of Patent: January 12, 1999
    Assignee: Massachusetts Institute of Technology
    Inventors: Kyungwon An, James J. Childs, Ramachandra Rao Dasari, Michael S. Feld